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The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects.
Br J Nutr. 1998 Nov; 80(5):411-8.BJ

Abstract

Previous studies in this laboratory have elicited a monophasic response in postprandial plasma triacylglycerol (TAG) level with fat intakes of 0.5 g fat/kg body weight accompanied by about 17 g carbohydrate as lactose. Recent studies involving the same level of fat with a higher level of carbohydrate, 136 g of which 60 g was sucrose, appeared to elicit a biphasic response. The present study compared these two test meals and showed a significant meal x time interaction for plasma total TAG (P = 0.0228) reflecting a monophasic response with the lower-carbohydrate test meal. The higher-carbohydrate meal induced significantly higher insulin and glucose-dependent insulinotropic polypeptide responses (P = 0.0009 and P = 0.0041 respectively). A significant meal x time interaction was seen for plasma non-esterified fatty acids (P = 0.0437). The biphasic plasma TAG response seen with the high-carbohydrate meal largely reflected the TAG-rich lipoprotein (TRL) or chylomicron fraction, which would tend to suggest a biphasic pattern of absorption. This was borne out by TRL-TAG fatty acid compositions. Both peak in the biphasic response showed active incorporation of the main dietary fatty acids, 18:1n-9, 18:2n-6 and 18:3n-3 into TRL-TAG. These results indicate that under the specific test-meal conditions used in the present study, a biphasic pattern of fat absorption was seen.

Authors+Show Affiliations

Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Republic of Ireland.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9924262

Citation

Shishehbor, F, et al. "The Effect of Acute Carbohydrate Load On the Monophasic or Biphasic Nature of the Postprandial Lipaemic Response to Acute Fat Ingestion in Human Subjects." The British Journal of Nutrition, vol. 80, no. 5, 1998, pp. 411-8.
Shishehbor F, Roche HM, Gibney MJ. The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects. Br J Nutr. 1998;80(5):411-8.
Shishehbor, F., Roche, H. M., & Gibney, M. J. (1998). The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects. The British Journal of Nutrition, 80(5), 411-8.
Shishehbor F, Roche HM, Gibney MJ. The Effect of Acute Carbohydrate Load On the Monophasic or Biphasic Nature of the Postprandial Lipaemic Response to Acute Fat Ingestion in Human Subjects. Br J Nutr. 1998;80(5):411-8. PubMed PMID: 9924262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects. AU - Shishehbor,F, AU - Roche,H M, AU - Gibney,M J, PY - 1999/1/30/pubmed PY - 1999/1/30/medline PY - 1999/1/30/entrez SP - 411 EP - 8 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 80 IS - 5 N2 - Previous studies in this laboratory have elicited a monophasic response in postprandial plasma triacylglycerol (TAG) level with fat intakes of 0.5 g fat/kg body weight accompanied by about 17 g carbohydrate as lactose. Recent studies involving the same level of fat with a higher level of carbohydrate, 136 g of which 60 g was sucrose, appeared to elicit a biphasic response. The present study compared these two test meals and showed a significant meal x time interaction for plasma total TAG (P = 0.0228) reflecting a monophasic response with the lower-carbohydrate test meal. The higher-carbohydrate meal induced significantly higher insulin and glucose-dependent insulinotropic polypeptide responses (P = 0.0009 and P = 0.0041 respectively). A significant meal x time interaction was seen for plasma non-esterified fatty acids (P = 0.0437). The biphasic plasma TAG response seen with the high-carbohydrate meal largely reflected the TAG-rich lipoprotein (TRL) or chylomicron fraction, which would tend to suggest a biphasic pattern of absorption. This was borne out by TRL-TAG fatty acid compositions. Both peak in the biphasic response showed active incorporation of the main dietary fatty acids, 18:1n-9, 18:2n-6 and 18:3n-3 into TRL-TAG. These results indicate that under the specific test-meal conditions used in the present study, a biphasic pattern of fat absorption was seen. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9924262/The_effect_of_acute_carbohydrate_load_on_the_monophasic_or_biphasic_nature_of_the_postprandial_lipaemic_response_to_acute_fat_ingestion_in_human_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114598001470/type/journal_article DB - PRIME DP - Unbound Medicine ER -