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Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin.
Ann N Y Acad Sci. 1998 Nov 20; 854:410-24.AN

Abstract

Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase and its inhibitory action on nitric oxide synthase. Finally, melatonin acts to stabilize cell membranes, thereby making them more resistant to oxidative attack. Melatonin is devoid of prooxidant actions. In models of oxidative stress, melatonin has been shown to resist lipid peroxidation induced by paraquat, lipopolysaccharide, ischemia-reperfusion, L-cysteine, potassium cyanide, cadmium chloride, glutathione depletion, alloxan, and alcohol ingestion. Likewise, free radical damage to DNA induced by ionizing radiation, the chemical carcinogen safrole, lipopolysaccharide, and kainic acid are inhibited by melatonin. These findings illustrate that melatonin, due to its high lipid solubility and modest aqueous solubility, is able to protect macromolecules in all parts of the cell from oxidative damage. Melatonin also prevents the inhibitory action of ruthenium red at the level of the mitochondria, thereby promoting ATP production. In humans, the total antioxidative capacity of serum is related to melatonin levels. Thus, the reduction in melatonin with age may be a factor in increased oxidative damage in the elderly.

Authors+Show Affiliations

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762, USA. reiter@uthscsa.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9928448

Citation

Reiter, R J., et al. "Reactive Oxygen Intermediates, Molecular Damage, and Aging. Relation to Melatonin." Annals of the New York Academy of Sciences, vol. 854, 1998, pp. 410-24.
Reiter RJ, Guerrero JM, Garcia JJ, et al. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998;854:410-24.
Reiter, R. J., Guerrero, J. M., Garcia, J. J., & Acuña-Castroviejo, D. (1998). Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Annals of the New York Academy of Sciences, 854, 410-24.
Reiter RJ, et al. Reactive Oxygen Intermediates, Molecular Damage, and Aging. Relation to Melatonin. Ann N Y Acad Sci. 1998 Nov 20;854:410-24. PubMed PMID: 9928448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. AU - Reiter,R J, AU - Guerrero,J M, AU - Garcia,J J, AU - Acuña-Castroviejo,D, PY - 1999/2/3/pubmed PY - 1999/2/3/medline PY - 1999/2/3/entrez SP - 410 EP - 24 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 854 N2 - Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase and its inhibitory action on nitric oxide synthase. Finally, melatonin acts to stabilize cell membranes, thereby making them more resistant to oxidative attack. Melatonin is devoid of prooxidant actions. In models of oxidative stress, melatonin has been shown to resist lipid peroxidation induced by paraquat, lipopolysaccharide, ischemia-reperfusion, L-cysteine, potassium cyanide, cadmium chloride, glutathione depletion, alloxan, and alcohol ingestion. Likewise, free radical damage to DNA induced by ionizing radiation, the chemical carcinogen safrole, lipopolysaccharide, and kainic acid are inhibited by melatonin. These findings illustrate that melatonin, due to its high lipid solubility and modest aqueous solubility, is able to protect macromolecules in all parts of the cell from oxidative damage. Melatonin also prevents the inhibitory action of ruthenium red at the level of the mitochondria, thereby promoting ATP production. In humans, the total antioxidative capacity of serum is related to melatonin levels. Thus, the reduction in melatonin with age may be a factor in increased oxidative damage in the elderly. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/9928448/Reactive_oxygen_intermediates_molecular_damage_and_aging__Relation_to_melatonin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=1998&volume=854&spage=410 DB - PRIME DP - Unbound Medicine ER -