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HIV infection and disturbances of vaginal flora during pregnancy.
J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 01; 20(1):52-9.JA

Abstract

Disturbances of vaginal flora are common among women of reproductive age. In areas of sub-Saharan Africa where the prevalence of HIV is high, the frequency of bacterial vaginosis (BV) is also high. In this study, we assessed the association of BV and other disturbances of vaginal flora with prevalent HIV infection in two cross-sectional studies among pregnant women in urban Malawi. The prevalence of HIV-1 was 23% in 1990 and 30% in 1993. Overall, 30% of the women had BV, 59% had mild or moderate disturbance of vaginal flora, and only 11% had normal vaginal flora. Increasing prevalence of HIV was significantly associated with increasing severity of disturbance of vaginal flora (p < .00001, chi2 trend test). This trend of increased prevalence persisted after controlling for concurrent sexually transmitted diseases (STDs), sexual activity, and socioeconomic factors. After multivariate adjustment for potential confounders, the odds ratio for the association of BV with prevalent HIV infection was 3.0 (95% confidence interval [CI], 2.4-3.8), that of moderate vaginal disturbance with HIV infection was 2.2 (95% CI, 1.7-2.8), and that of mild vaginal disturbance with HIV infection was 1.6 (95% CI, 1.3-2.1). Among women with BV, HIV infection was higher among younger women than older, implying more recent infection. Although these studies were cross-sectional, our data suggest that BV could be associated with increased susceptibility to HIV infection.

Authors+Show Affiliations

School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA. ttaha@jhsph.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9928730

Citation

Taha, T E., et al. "HIV Infection and Disturbances of Vaginal Flora During Pregnancy." Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association, vol. 20, no. 1, 1999, pp. 52-9.
Taha TE, Gray RH, Kumwenda NI, et al. HIV infection and disturbances of vaginal flora during pregnancy. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20(1):52-9.
Taha, T. E., Gray, R. H., Kumwenda, N. I., Hoover, D. R., Mtimavalye, L. A., Liomba, G. N., Chiphangwi, J. D., Dallabetta, G. A., & Miotti, P. G. (1999). HIV infection and disturbances of vaginal flora during pregnancy. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association, 20(1), 52-9.
Taha TE, et al. HIV Infection and Disturbances of Vaginal Flora During Pregnancy. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 1;20(1):52-9. PubMed PMID: 9928730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV infection and disturbances of vaginal flora during pregnancy. AU - Taha,T E, AU - Gray,R H, AU - Kumwenda,N I, AU - Hoover,D R, AU - Mtimavalye,L A, AU - Liomba,G N, AU - Chiphangwi,J D, AU - Dallabetta,G A, AU - Miotti,P G, PY - 1999/2/3/pubmed PY - 1999/2/3/medline PY - 1999/2/3/entrez KW - Acquired Immunodeficiency Syndrome KW - Africa KW - Africa South Of The Sahara KW - Bacterial And Fungal Diseases KW - Biology KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Eastern Africa KW - English Speaking Africa KW - Hiv Infections KW - Infections KW - Malawi KW - Population KW - Population Characteristics KW - Pregnant Women KW - Research Report KW - Risk Factors KW - Urban Population--women KW - Vaginal Abnormalities KW - Viral Diseases SP - 52 EP - 9 JF - Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association JO - J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. VL - 20 IS - 1 N2 - Disturbances of vaginal flora are common among women of reproductive age. In areas of sub-Saharan Africa where the prevalence of HIV is high, the frequency of bacterial vaginosis (BV) is also high. In this study, we assessed the association of BV and other disturbances of vaginal flora with prevalent HIV infection in two cross-sectional studies among pregnant women in urban Malawi. The prevalence of HIV-1 was 23% in 1990 and 30% in 1993. Overall, 30% of the women had BV, 59% had mild or moderate disturbance of vaginal flora, and only 11% had normal vaginal flora. Increasing prevalence of HIV was significantly associated with increasing severity of disturbance of vaginal flora (p < .00001, chi2 trend test). This trend of increased prevalence persisted after controlling for concurrent sexually transmitted diseases (STDs), sexual activity, and socioeconomic factors. After multivariate adjustment for potential confounders, the odds ratio for the association of BV with prevalent HIV infection was 3.0 (95% confidence interval [CI], 2.4-3.8), that of moderate vaginal disturbance with HIV infection was 2.2 (95% CI, 1.7-2.8), and that of mild vaginal disturbance with HIV infection was 1.6 (95% CI, 1.3-2.1). Among women with BV, HIV infection was higher among younger women than older, implying more recent infection. Although these studies were cross-sectional, our data suggest that BV could be associated with increased susceptibility to HIV infection. SN - 1077-9450 UR - https://www.unboundmedicine.com/medline/citation/9928730/HIV_infection_and_disturbances_of_vaginal_flora_during_pregnancy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9928730.ui DB - PRIME DP - Unbound Medicine ER -