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Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology.
AJR Am J Roentgenol. 1999 Feb; 172(2):319-23.AA

Abstract

OBJECTIVE

Our objective was to assess our experience in diagnosing pure tubular carcinoma of the breast and to correlate the radiologic and histopathologic features.

MATERIALS AND METHODS

A retrospective review of 932 consecutive cases of proven breast cancer diagnosed between 1990 and 1997 revealed 78 cases (8.4%) of tubular carcinoma in 69 patients. Clinical, imaging, cytologic, and histologic findings were analyzed.

RESULTS

Mammography revealed tubular carcinoma in 68 (87%) of the 78 cases. Sonography showed tubular carcinoma in all 38 cases in which it was used; nine of these lesions were mammographically occult. These nine lesions were slightly, but not significantly (p < .05), smaller than the 29 lesions that had also been detected on mammography. Large core needle biopsy was performed in 22 patients (sensitivity, 91%). At biopsy, diagnoses were malignant (n = 16 [73%]), suspicious (n = 4 [18%]), atypia (n = 1 [4.5%]), and benign (n = 1 [4.5%]). Fine-needle aspiration biopsy was used to evaluate 36 cases of tubular carcinoma (sensitivity, 50%); cytologic diagnoses were malignant (n = 15 [42%]), suspicious (n = 3 [8%]), atypia (n = 10 [28%]), and benign (n = 8 [22%]). Only 15 (19%) of the 78 tubular carcinomas were palpable. Other tumors were detected within the excised tissue in 47 of the patients (68%); of these other types of lesions, ductal carcinoma in situ was found most often.

CONCLUSION

Most cases of tubular carcinoma can be revealed by mammography; for mammographically occult tubular carcinoma, sonography can be performed. The rate of accuracy for determining the presence of tubular carcinoma is higher with large core needle biopsy than with fine-needle aspiration biopsy. Finally, when tubular carcinoma is diagnosed, other histologic types of carcinoma often occur in the same breast.

Authors+Show Affiliations

Murray Hill Radiology and Mammography, New York, NY 10016, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9930775

Citation

Mitnick, J S., et al. "Tubular Carcinoma of the Breast: Sensitivity of Diagnostic Techniques and Correlation With Histopathology." AJR. American Journal of Roentgenology, vol. 172, no. 2, 1999, pp. 319-23.
Mitnick JS, Gianutsos R, Pollack AH, et al. Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR Am J Roentgenol. 1999;172(2):319-23.
Mitnick, J. S., Gianutsos, R., Pollack, A. H., Susman, M., Baskin, B. L., Ko, W. D., Pressman, P. I., Feiner, H. D., & Roses, D. F. (1999). Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AJR. American Journal of Roentgenology, 172(2), 319-23.
Mitnick JS, et al. Tubular Carcinoma of the Breast: Sensitivity of Diagnostic Techniques and Correlation With Histopathology. AJR Am J Roentgenol. 1999;172(2):319-23. PubMed PMID: 9930775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tubular carcinoma of the breast: sensitivity of diagnostic techniques and correlation with histopathology. AU - Mitnick,J S, AU - Gianutsos,R, AU - Pollack,A H, AU - Susman,M, AU - Baskin,B L, AU - Ko,W D, AU - Pressman,P I, AU - Feiner,H D, AU - Roses,D F, PY - 1999/2/4/pubmed PY - 1999/2/4/medline PY - 1999/2/4/entrez SP - 319 EP - 23 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 172 IS - 2 N2 - OBJECTIVE: Our objective was to assess our experience in diagnosing pure tubular carcinoma of the breast and to correlate the radiologic and histopathologic features. MATERIALS AND METHODS: A retrospective review of 932 consecutive cases of proven breast cancer diagnosed between 1990 and 1997 revealed 78 cases (8.4%) of tubular carcinoma in 69 patients. Clinical, imaging, cytologic, and histologic findings were analyzed. RESULTS: Mammography revealed tubular carcinoma in 68 (87%) of the 78 cases. Sonography showed tubular carcinoma in all 38 cases in which it was used; nine of these lesions were mammographically occult. These nine lesions were slightly, but not significantly (p < .05), smaller than the 29 lesions that had also been detected on mammography. Large core needle biopsy was performed in 22 patients (sensitivity, 91%). At biopsy, diagnoses were malignant (n = 16 [73%]), suspicious (n = 4 [18%]), atypia (n = 1 [4.5%]), and benign (n = 1 [4.5%]). Fine-needle aspiration biopsy was used to evaluate 36 cases of tubular carcinoma (sensitivity, 50%); cytologic diagnoses were malignant (n = 15 [42%]), suspicious (n = 3 [8%]), atypia (n = 10 [28%]), and benign (n = 8 [22%]). Only 15 (19%) of the 78 tubular carcinomas were palpable. Other tumors were detected within the excised tissue in 47 of the patients (68%); of these other types of lesions, ductal carcinoma in situ was found most often. CONCLUSION: Most cases of tubular carcinoma can be revealed by mammography; for mammographically occult tubular carcinoma, sonography can be performed. The rate of accuracy for determining the presence of tubular carcinoma is higher with large core needle biopsy than with fine-needle aspiration biopsy. Finally, when tubular carcinoma is diagnosed, other histologic types of carcinoma often occur in the same breast. SN - 0361-803X UR - https://www.unboundmedicine.com/medline/citation/9930775/Tubular_carcinoma_of_the_breast:_sensitivity_of_diagnostic_techniques_and_correlation_with_histopathology_ L2 - https://www.ajronline.org/doi/10.2214/ajr.172.2.9930775 DB - PRIME DP - Unbound Medicine ER -