Feverfew as a preventive treatment for migraine: a systematic review.Cephalalgia 1998; 18(10):704-8C
Feverfew is a popular herbal remedy advocated for the prevention of migraine.
The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention.
Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998).
Only randomized, placebo-controlled, double-blind trials were included.
All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score.
Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist.
The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt.