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Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12.
Scand J Gastroenterol. 1976; 11(7):689-95.SJ

Abstract

The mean absorption of vitamin B12 (Schilling test) was 13.1 +/- 1.0 (% +/- S.E.M.) in 21 patients with chronic pancreatic insufficiency and 17.6 +/- 1.4 in 13 control patients (p less than 0.01). There was no correlation between pancreatic bicarbonate production after secretion stimulation and vitamin B12 absorption in the patient group (r = 0.117). Human duodenal juice reduced the uptake of 57CoB12-rat intrinsic factor (IF) by perfused rat small intestinal segments in vivo (p less than 0.01) as well as the uptake of 57CoB12-human IF by purified guinea-pig intestinal brush borders in vitro (p less than 0.01). The results confirm reduced absorption of vitamin B12 in chronic pancreatic insufficiency, but the mechanism remains uncertain.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

996435

Citation

Von Der Lippe, G, et al. "Intestinal Absorption of Vitamin B12 in Patients With Chronic Pancreatic Insufficiency and the Effect of Human Duodenal Juice On the Intestinal Uptake of Vitamin B12." Scandinavian Journal of Gastroenterology, vol. 11, no. 7, 1976, pp. 689-95.
Von Der Lippe G, Andersen KJ, Schjönsby H. Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12. Scand J Gastroenterol. 1976;11(7):689-95.
Von Der Lippe, G., Andersen, K. J., & Schjönsby, H. (1976). Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12. Scandinavian Journal of Gastroenterology, 11(7), 689-95.
Von Der Lippe G, Andersen KJ, Schjönsby H. Intestinal Absorption of Vitamin B12 in Patients With Chronic Pancreatic Insufficiency and the Effect of Human Duodenal Juice On the Intestinal Uptake of Vitamin B12. Scand J Gastroenterol. 1976;11(7):689-95. PubMed PMID: 996435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12. AU - Von Der Lippe,G, AU - Andersen,K J, AU - Schjönsby,H, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 689 EP - 95 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 11 IS - 7 N2 - The mean absorption of vitamin B12 (Schilling test) was 13.1 +/- 1.0 (% +/- S.E.M.) in 21 patients with chronic pancreatic insufficiency and 17.6 +/- 1.4 in 13 control patients (p less than 0.01). There was no correlation between pancreatic bicarbonate production after secretion stimulation and vitamin B12 absorption in the patient group (r = 0.117). Human duodenal juice reduced the uptake of 57CoB12-rat intrinsic factor (IF) by perfused rat small intestinal segments in vivo (p less than 0.01) as well as the uptake of 57CoB12-human IF by purified guinea-pig intestinal brush borders in vitro (p less than 0.01). The results confirm reduced absorption of vitamin B12 in chronic pancreatic insufficiency, but the mechanism remains uncertain. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/996435/Intestinal_absorption_of_vitamin_B12_in_patients_with_chronic_pancreatic_insufficiency_and_the_effect_of_human_duodenal_juice_on_the_intestinal_uptake_of_vitamin_B12_ L2 - https://medlineplus.gov/pancreaticdiseases.html DB - PRIME DP - Unbound Medicine ER -