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Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India.
Oral Dis 1998; 4(3):200-6OD

Abstract

OBJECTIVES

To investigate the relationship of specific nutrients and food items with oral precancerous lesions among tobacco users.

DESIGN

A population-based case-control study.

SETTING

Villages in Palitana taluk of Bhavnagar district, Gujarat, India.

SUBJECTS AND METHODS

An interviewer-administered food frequency questionnaire, developed and validated for this population, was used to estimate nutrient intake in blinded, house-to-house interviews. Among 5018 male tobacco users, 318 were diagnosed as cases. An equal number of controls matched on age (+/- 5 years), sex, village, and use of tobacco were selected.

MAIN OUTCOME MEASURES

Odds ratios (OR) from multiple logistic regression analysis controlling for relevant variables (type of tobacco use and economic status).

RESULTS

A protective effect of fibre was observed for both oral submucous fibrosis (OSF) and leukoplakia, with 10% reduction in risk per g day-1 (P < 0.05). Ascorbic acid appeared to be protective against leukoplakia with the halving of risk in the two highest quartiles of intake (versus the lowest quartile: OR = 0.46 and 0.44, respectively; P < 0.10). A protective effect of tomato consumption was observed in leukoplakia and a suggestion of a protective effect of wheat in OSF.

CONCLUSION

In addition to tobacco use, intake of specific nutrients may have a role in the development of oral precancerous lesions.

Authors+Show Affiliations

Epidemiology Research Unit, Tata Institute of Fundamental Research, Bombay, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9972171

Citation

Gupta, P C., et al. "Dietary Factors in Oral Leukoplakia and Submucous Fibrosis in a Population-based Case Control Study in Gujarat, India." Oral Diseases, vol. 4, no. 3, 1998, pp. 200-6.
Gupta PC, Hebert JR, Bhonsle RB, et al. Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. Oral Dis. 1998;4(3):200-6.
Gupta, P. C., Hebert, J. R., Bhonsle, R. B., Sinor, P. N., Mehta, H., & Mehta, F. S. (1998). Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. Oral Diseases, 4(3), pp. 200-6.
Gupta PC, et al. Dietary Factors in Oral Leukoplakia and Submucous Fibrosis in a Population-based Case Control Study in Gujarat, India. Oral Dis. 1998;4(3):200-6. PubMed PMID: 9972171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. AU - Gupta,P C, AU - Hebert,J R, AU - Bhonsle,R B, AU - Sinor,P N, AU - Mehta,H, AU - Mehta,F S, PY - 1999/2/11/pubmed PY - 1999/2/11/medline PY - 1999/2/11/entrez SP - 200 EP - 6 JF - Oral diseases JO - Oral Dis VL - 4 IS - 3 N2 - OBJECTIVES: To investigate the relationship of specific nutrients and food items with oral precancerous lesions among tobacco users. DESIGN: A population-based case-control study. SETTING: Villages in Palitana taluk of Bhavnagar district, Gujarat, India. SUBJECTS AND METHODS: An interviewer-administered food frequency questionnaire, developed and validated for this population, was used to estimate nutrient intake in blinded, house-to-house interviews. Among 5018 male tobacco users, 318 were diagnosed as cases. An equal number of controls matched on age (+/- 5 years), sex, village, and use of tobacco were selected. MAIN OUTCOME MEASURES: Odds ratios (OR) from multiple logistic regression analysis controlling for relevant variables (type of tobacco use and economic status). RESULTS: A protective effect of fibre was observed for both oral submucous fibrosis (OSF) and leukoplakia, with 10% reduction in risk per g day-1 (P < 0.05). Ascorbic acid appeared to be protective against leukoplakia with the halving of risk in the two highest quartiles of intake (versus the lowest quartile: OR = 0.46 and 0.44, respectively; P < 0.10). A protective effect of tomato consumption was observed in leukoplakia and a suggestion of a protective effect of wheat in OSF. CONCLUSION: In addition to tobacco use, intake of specific nutrients may have a role in the development of oral precancerous lesions. SN - 1354-523X UR - https://www.unboundmedicine.com/medline/citation/9972171/Dietary_factors_in_oral_leukoplakia_and_submucous_fibrosis_in_a_population_based_case_control_study_in_Gujarat_India_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1354-523X&amp;date=1998&amp;volume=4&amp;issue=3&amp;spage=200 DB - PRIME DP - Unbound Medicine ER -