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Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge?
Pharm World Sci. 1998 Dec; 20(6):253-7.PW

Abstract

Drug reactions in patients with HIV infection, e.g. fever or rash, are a frequently occurring clinical problem. These side effects particularly are observed with sulfonamides; however, many other drugs have also shown to induce allergic reactions when given to patients with HIV infection. The production of hydroxylamines has been put forward as one of the explanations for these high incidence of reactions on drugs. Since sulfonamides are the first choice of therapy for the treatment and prophylaxis of Pneumocystis carinii pneumonia, several strategies have been developed to circumvent drug reactions. In general rechallenge or desensitization are recommended in literature. This article discusses the results and risks of rechallenge and desensitization with sulfonamides or other drugs, as mentioned in the literature. Furthermore preliminary results of rechallenge with a sulfonamide, which is not metabolized into hydroxylamines, are presented. From the data in the literature it is concluded that desensitization should be preferred to rechallenge.

Authors+Show Affiliations

Department of General Internal Medicine, University Hospital Nijmegen St. Radboud, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9972526

Citation

Koopmans, P P., and D M. Burger. "Managing Drug Reactions to Sulfonamides and Other Drugs in HIV Infection: Desensitization Rather Than Rechallenge?" Pharmacy World & Science : PWS, vol. 20, no. 6, 1998, pp. 253-7.
Koopmans PP, Burger DM. Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge? Pharm World Sci. 1998;20(6):253-7.
Koopmans, P. P., & Burger, D. M. (1998). Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge? Pharmacy World & Science : PWS, 20(6), 253-7.
Koopmans PP, Burger DM. Managing Drug Reactions to Sulfonamides and Other Drugs in HIV Infection: Desensitization Rather Than Rechallenge. Pharm World Sci. 1998;20(6):253-7. PubMed PMID: 9972526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge? AU - Koopmans,P P, AU - Burger,D M, PY - 1999/2/11/pubmed PY - 1999/2/11/medline PY - 1999/2/11/entrez SP - 253 EP - 7 JF - Pharmacy world & science : PWS JO - Pharm World Sci VL - 20 IS - 6 N2 - Drug reactions in patients with HIV infection, e.g. fever or rash, are a frequently occurring clinical problem. These side effects particularly are observed with sulfonamides; however, many other drugs have also shown to induce allergic reactions when given to patients with HIV infection. The production of hydroxylamines has been put forward as one of the explanations for these high incidence of reactions on drugs. Since sulfonamides are the first choice of therapy for the treatment and prophylaxis of Pneumocystis carinii pneumonia, several strategies have been developed to circumvent drug reactions. In general rechallenge or desensitization are recommended in literature. This article discusses the results and risks of rechallenge and desensitization with sulfonamides or other drugs, as mentioned in the literature. Furthermore preliminary results of rechallenge with a sulfonamide, which is not metabolized into hydroxylamines, are presented. From the data in the literature it is concluded that desensitization should be preferred to rechallenge. SN - 0928-1231 UR - https://www.unboundmedicine.com/medline/citation/9972526/Managing_drug_reactions_to_sulfonamides_and_other_drugs_in_HIV_infection:_desensitization_rather_than_rechallenge L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9972526.ui DB - PRIME DP - Unbound Medicine ER -