Tags

Type your tag names separated by a space and hit enter

Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses.
Cancer Res 1999; 59(3):753-7CR

Abstract

High-risk types of human papillomaviruses (hrHPVs) may be a necessary cause in cervical cancer and in some subtype of anal, vulvar, and penile cancers. Large studies aimed at characterizing hrHPV-associated and non-hrHPV-associated subtypes of anal carcinomas are, however, lacking. We searched for human papillomavirus type 16 and 13 other hrHPVs in tumor tissue by PCR and performed a systematic histological evaluation of specimens from 386 patients with anal cancer (86% invasive; 302 women and 84 men). Cancers in women and homosexual men were more often hrHPV positive (P < 0.01) and located in the anal canal (P < or = 0.01) than were cancers in heterosexual men. In both women and men, anal canal cancers contained hrHPV clearly more often than did perianal skin cancers, and increasing hrHPV positivity was seen with higher localization in the anal canal. Indeed, 95 and 83% of cancers involving the anal canal in women and men, respectively, were hrHPV positive versus 80 and 28% of perianal skin cancers (P-trend < 0.001). Basaloid feature, adjacent anal intraepithelial neoplasia, poor or absent keratinization, and a predominance of small or medium neoplastic cells were all strongly positively associated with hrHPV status. Like cancer of the uterine cervix, the development of cancer of the anal canal may require infection with hrHPV, whereas a dual etiology of perianal skin cancers bears parallels to vulvar and penile cancers.

Authors+Show Affiliations

Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen S.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9973228

Citation

Frisch, M, et al. "Variants of Squamous Cell Carcinoma of the Anal Canal and Perianal Skin and Their Relation to Human Papillomaviruses." Cancer Research, vol. 59, no. 3, 1999, pp. 753-7.
Frisch M, Fenger C, van den Brule AJ, et al. Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999;59(3):753-7.
Frisch, M., Fenger, C., van den Brule, A. J., Sørensen, P., Meijer, C. J., Walboomers, J. M., ... Glimelius, B. (1999). Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Research, 59(3), pp. 753-7.
Frisch M, et al. Variants of Squamous Cell Carcinoma of the Anal Canal and Perianal Skin and Their Relation to Human Papillomaviruses. Cancer Res. 1999 Feb 1;59(3):753-7. PubMed PMID: 9973228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. AU - Frisch,M, AU - Fenger,C, AU - van den Brule,A J, AU - Sørensen,P, AU - Meijer,C J, AU - Walboomers,J M, AU - Adami,H O, AU - Melbye,M, AU - Glimelius,B, PY - 1999/2/11/pubmed PY - 1999/2/11/medline PY - 1999/2/11/entrez SP - 753 EP - 7 JF - Cancer research JO - Cancer Res. VL - 59 IS - 3 N2 - High-risk types of human papillomaviruses (hrHPVs) may be a necessary cause in cervical cancer and in some subtype of anal, vulvar, and penile cancers. Large studies aimed at characterizing hrHPV-associated and non-hrHPV-associated subtypes of anal carcinomas are, however, lacking. We searched for human papillomavirus type 16 and 13 other hrHPVs in tumor tissue by PCR and performed a systematic histological evaluation of specimens from 386 patients with anal cancer (86% invasive; 302 women and 84 men). Cancers in women and homosexual men were more often hrHPV positive (P < 0.01) and located in the anal canal (P < or = 0.01) than were cancers in heterosexual men. In both women and men, anal canal cancers contained hrHPV clearly more often than did perianal skin cancers, and increasing hrHPV positivity was seen with higher localization in the anal canal. Indeed, 95 and 83% of cancers involving the anal canal in women and men, respectively, were hrHPV positive versus 80 and 28% of perianal skin cancers (P-trend < 0.001). Basaloid feature, adjacent anal intraepithelial neoplasia, poor or absent keratinization, and a predominance of small or medium neoplastic cells were all strongly positively associated with hrHPV status. Like cancer of the uterine cervix, the development of cancer of the anal canal may require infection with hrHPV, whereas a dual etiology of perianal skin cancers bears parallels to vulvar and penile cancers. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9973228/Variants_of_squamous_cell_carcinoma_of_the_anal_canal_and_perianal_skin_and_their_relation_to_human_papillomaviruses_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=9973228 DB - PRIME DP - Unbound Medicine ER -