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[Doppler tissue imaging: a new method in the study of diastolic function in left ventricular hypertrophy].
G Ital Cardiol. 1999 Jan; 29(1):63-71.GI

Abstract

BACKGROUND

Many factors influence diastolic function indexes obtained by monitoring left ventricular filling. Recent reports suggest that the study of myocardial wall velocity with Doppler tissue imaging (DTI) can give diastolic function parameters that are less affected by the same factors. An altered diastolic function has been demonstrated with invasive methods in patients with left ventricular hypertrophy (LVH). The aims of this study were 1) to compare a group of healthy subjects with a group of patients with LVH and presumably affected by diastolic dysfunction, to try to demonstrate if DTI could give new indexes to discriminate between the two groups; 2) to compare the indexes obtained with DTI against the ones given by Doppler study of left ventricular filling in the two populations.

MATERIALS AND METHODS

Forty-two patients with LVH were compared to forty normal subjects. We studied the posterior wall velocity with pulsed DTI from parasternal view, measuring the early diastolic velocity (E'), the late diastolic velocity (A') and the E'/A' ratio. In addition, we estimated the usual ventricular filling parameters and the time interval between R wave of ECG and the peaks of E' and E waves.

RESULTS

At left ventricular filling, patients with LVH showed an increase in A-wave peak velocity (mean 75.3 cm/s versus 66.4 cm/s; p < 0.05) and prolonged deceleration time (mean 216 ms versus 181 ms; p < 0.05), as compared to normal reference subjects. E-wave peak velocity and E/A ratio did not differ between the two groups. At DTI, patients with LVH had decreased early diastolic velocity (E') (mean 9 cm/s versus 12 cm/s; p < 0.05) and E'/A' ratio (mean 1.53 versus 1.91; p < 0.05) as compared to the control group. We observed an inverse correlation between E' wave and age in normal subjects. There was no correlation between the early diastolic myocardial velocity (E') and early inflow velocity (E) in both groups. A correlation was found between A and A' waves in normal subjects, but not in hypertrophic ones. The E'-wave peak always preceded the E-wave peak in all the subjects.

CONCLUSION

Diastolic function indexes achieved by DTI can offer additional information that is independent of the data derived from left ventricular filling.

Authors+Show Affiliations

Unità Operativa di Cardiologia, Ospedale S. Maria del Prato, Feltre.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

ita

PubMed ID

9987050

Citation

Vezù, L, et al. "[Doppler Tissue Imaging: a New Method in the Study of Diastolic Function in Left Ventricular Hypertrophy]." Giornale Italiano Di Cardiologia, vol. 29, no. 1, 1999, pp. 63-71.
Vezù L, Bilardo G, Collet L, et al. [Doppler tissue imaging: a new method in the study of diastolic function in left ventricular hypertrophy]. G Ital Cardiol. 1999;29(1):63-71.
Vezù, L., Bilardo, G., Collet, L., Noventa, F., & Delise, P. (1999). [Doppler tissue imaging: a new method in the study of diastolic function in left ventricular hypertrophy]. Giornale Italiano Di Cardiologia, 29(1), 63-71.
Vezù L, et al. [Doppler Tissue Imaging: a New Method in the Study of Diastolic Function in Left Ventricular Hypertrophy]. G Ital Cardiol. 1999;29(1):63-71. PubMed PMID: 9987050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Doppler tissue imaging: a new method in the study of diastolic function in left ventricular hypertrophy]. AU - Vezù,L, AU - Bilardo,G, AU - Collet,L, AU - Noventa,F, AU - Delise,P, PY - 1999/2/13/pubmed PY - 1999/2/13/medline PY - 1999/2/13/entrez SP - 63 EP - 71 JF - Giornale italiano di cardiologia JO - G Ital Cardiol VL - 29 IS - 1 N2 - BACKGROUND: Many factors influence diastolic function indexes obtained by monitoring left ventricular filling. Recent reports suggest that the study of myocardial wall velocity with Doppler tissue imaging (DTI) can give diastolic function parameters that are less affected by the same factors. An altered diastolic function has been demonstrated with invasive methods in patients with left ventricular hypertrophy (LVH). The aims of this study were 1) to compare a group of healthy subjects with a group of patients with LVH and presumably affected by diastolic dysfunction, to try to demonstrate if DTI could give new indexes to discriminate between the two groups; 2) to compare the indexes obtained with DTI against the ones given by Doppler study of left ventricular filling in the two populations. MATERIALS AND METHODS: Forty-two patients with LVH were compared to forty normal subjects. We studied the posterior wall velocity with pulsed DTI from parasternal view, measuring the early diastolic velocity (E'), the late diastolic velocity (A') and the E'/A' ratio. In addition, we estimated the usual ventricular filling parameters and the time interval between R wave of ECG and the peaks of E' and E waves. RESULTS: At left ventricular filling, patients with LVH showed an increase in A-wave peak velocity (mean 75.3 cm/s versus 66.4 cm/s; p < 0.05) and prolonged deceleration time (mean 216 ms versus 181 ms; p < 0.05), as compared to normal reference subjects. E-wave peak velocity and E/A ratio did not differ between the two groups. At DTI, patients with LVH had decreased early diastolic velocity (E') (mean 9 cm/s versus 12 cm/s; p < 0.05) and E'/A' ratio (mean 1.53 versus 1.91; p < 0.05) as compared to the control group. We observed an inverse correlation between E' wave and age in normal subjects. There was no correlation between the early diastolic myocardial velocity (E') and early inflow velocity (E) in both groups. A correlation was found between A and A' waves in normal subjects, but not in hypertrophic ones. The E'-wave peak always preceded the E-wave peak in all the subjects. CONCLUSION: Diastolic function indexes achieved by DTI can offer additional information that is independent of the data derived from left ventricular filling. SN - 0046-5968 UR - https://www.unboundmedicine.com/medline/citation/9987050/[Doppler_tissue_imaging:_a_new_method_in_the_study_of_diastolic_function_in_left_ventricular_hypertrophy]_ DB - PRIME DP - Unbound Medicine ER -