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[Relation of the thickness of the intima and media of the common carotid artery, atherosclerotic plaque in the carotids and manifestations of atherosclerosis in the vessels of the lower extremity in comparison to coronary atherosclerosis].
Cas Lek Cesk 1998; 137(23):716-20CL

Abstract

BACKGROUND

Concomitant occurrence of carotid atherosclerosis, coronary artery disease (CAD) and peripheral vascular disease (PVD) has been described in a number of studies. The objective of the present trial was to assess the degree of correlation between atherosclerosis of the carotid beds as well as PVD and the extent of CAD.

METHODS AND RESULTS

Carotid morphologies of 170 patients in total (121 men, 49 women), ranging between 23 and 81 years in age were assessed ultrasonographically. Their carotid beds searched for plaques, stenoses and occlusions. In all patients intima-media thickness (IMT) of the common carotid artery (CCA) were measured ultrasonographically. In addition, case histories of PVD were taken. CAD was proved angiographically in 138 patients. Plaques in carotid beds were found in 98 patients, carotid artery stenoses > 75% were found in 4 patients whereas complete carotid occlusion was not detected in any patient. Clinically manifested PVD was found in 20 patients. A significant difference in IMT of the CCA was assessed by t-test between patients having and not having CAD (0.67 +/- 0.16 mm vs. 0.87 +/- 0.24 mm; P < 0.0001). The correlation between the IMT of the CCA and extent of CAD was weak (r = 0.30, p < 0.01). A positive correlation between carotid plaque occurrence and the number of CAD-affected arteries was statistically assessed (Trend test: P = 0.0001). The sensitivity of incidence of plaques on the carotid beds for prediction of CAD was 64%, the specificity 72%, the positive predictive value 91% and the negative predictive value 32%. The sensitivity of clinically manifested PVD for prediction of CAD was 15%, the specificity 100%, the positive predictive value 100% and the negative predictive value 21%.

CONCLUSIONS

The authors confirmed a statistically significant but weak correlation between IMT of the CCA and severity of CAD. They found a positive trend between the occurrence of carotid plaques and the number of CAD-affected arteries. The presence of carotid plaques and clinically manifested PVD were confirmed as a reliable positive predictive factors for CAD.

Authors+Show Affiliations

III. Interní klinika, LF UK a VFN, Praha. robert.holaj@post.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

cze

PubMed ID

9990175

Citation

Holaj, R, et al. "[Relation of the Thickness of the Intima and Media of the Common Carotid Artery, Atherosclerotic Plaque in the Carotids and Manifestations of Atherosclerosis in the Vessels of the Lower Extremity in Comparison to Coronary Atherosclerosis]." Casopis Lekaru Ceskych, vol. 137, no. 23, 1998, pp. 716-20.
Holaj R, Spácil J, Petrásek J, et al. [Relation of the thickness of the intima and media of the common carotid artery, atherosclerotic plaque in the carotids and manifestations of atherosclerosis in the vessels of the lower extremity in comparison to coronary atherosclerosis]. Cas Lek Cesk. 1998;137(23):716-20.
Holaj, R., Spácil, J., Petrásek, J., Malík, J., Aschermann, M., & Haas, T. (1998). [Relation of the thickness of the intima and media of the common carotid artery, atherosclerotic plaque in the carotids and manifestations of atherosclerosis in the vessels of the lower extremity in comparison to coronary atherosclerosis]. Casopis Lekaru Ceskych, 137(23), pp. 716-20.
Holaj R, et al. [Relation of the Thickness of the Intima and Media of the Common Carotid Artery, Atherosclerotic Plaque in the Carotids and Manifestations of Atherosclerosis in the Vessels of the Lower Extremity in Comparison to Coronary Atherosclerosis]. Cas Lek Cesk. 1998 Nov 30;137(23):716-20. PubMed PMID: 9990175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relation of the thickness of the intima and media of the common carotid artery, atherosclerotic plaque in the carotids and manifestations of atherosclerosis in the vessels of the lower extremity in comparison to coronary atherosclerosis]. AU - Holaj,R, AU - Spácil,J, AU - Petrásek,J, AU - Malík,J, AU - Aschermann,M, AU - Haas,T, PY - 1999/2/17/pubmed PY - 1999/2/17/medline PY - 1999/2/17/entrez SP - 716 EP - 20 JF - Casopis lekaru ceskych JO - Cas. Lek. Cesk. VL - 137 IS - 23 N2 - BACKGROUND: Concomitant occurrence of carotid atherosclerosis, coronary artery disease (CAD) and peripheral vascular disease (PVD) has been described in a number of studies. The objective of the present trial was to assess the degree of correlation between atherosclerosis of the carotid beds as well as PVD and the extent of CAD. METHODS AND RESULTS: Carotid morphologies of 170 patients in total (121 men, 49 women), ranging between 23 and 81 years in age were assessed ultrasonographically. Their carotid beds searched for plaques, stenoses and occlusions. In all patients intima-media thickness (IMT) of the common carotid artery (CCA) were measured ultrasonographically. In addition, case histories of PVD were taken. CAD was proved angiographically in 138 patients. Plaques in carotid beds were found in 98 patients, carotid artery stenoses > 75% were found in 4 patients whereas complete carotid occlusion was not detected in any patient. Clinically manifested PVD was found in 20 patients. A significant difference in IMT of the CCA was assessed by t-test between patients having and not having CAD (0.67 +/- 0.16 mm vs. 0.87 +/- 0.24 mm; P < 0.0001). The correlation between the IMT of the CCA and extent of CAD was weak (r = 0.30, p < 0.01). A positive correlation between carotid plaque occurrence and the number of CAD-affected arteries was statistically assessed (Trend test: P = 0.0001). The sensitivity of incidence of plaques on the carotid beds for prediction of CAD was 64%, the specificity 72%, the positive predictive value 91% and the negative predictive value 32%. The sensitivity of clinically manifested PVD for prediction of CAD was 15%, the specificity 100%, the positive predictive value 100% and the negative predictive value 21%. CONCLUSIONS: The authors confirmed a statistically significant but weak correlation between IMT of the CCA and severity of CAD. They found a positive trend between the occurrence of carotid plaques and the number of CAD-affected arteries. The presence of carotid plaques and clinically manifested PVD were confirmed as a reliable positive predictive factors for CAD. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/9990175/[Relation_of_the_thickness_of_the_intima_and_media_of_the_common_carotid_artery_atherosclerotic_plaque_in_the_carotids_and_manifestations_of_atherosclerosis_in_the_vessels_of_the_lower_extremity_in_comparison_to_coronary_atherosclerosis]_ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -