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Immunohistochemical localization of secretory immunoglobulins in the main excretory duct of the human submandibular gland.
Arch Histol Cytol. 1998 Dec; 61(5):427-32.AH

Abstract

The localization of IgA, IgG, and IgM was investigated immunohistochemically in the mucosal surface of the main excretory duct of the human submandibular gland in order to verify the possible antimicrobial properties of this duct. Only secretory IgA-immunoreactivity was recognized in the epithelial cells of the duct. An intense immunoreactivity was observed in the cytoplasm of some cells and at the luminal surface of most of the cells. Clusters of IgA-positive immuno-competent cells were also recognizable in the subepithelial layers. No reactivity for IgG and IgM was noticed. The results suggest that the ductal epithelium may actively be involved in the release of secretory IgA, which could play a prominent role in the local defense mechanism of the duct.

Authors+Show Affiliations

Department of Cytomorphology, University of Cagliari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9990426

Citation

Perra, M T., et al. "Immunohistochemical Localization of Secretory Immunoglobulins in the Main Excretory Duct of the Human Submandibular Gland." Archives of Histology and Cytology, vol. 61, no. 5, 1998, pp. 427-32.
Perra MT, Puxeddu R, Maxia C, et al. Immunohistochemical localization of secretory immunoglobulins in the main excretory duct of the human submandibular gland. Arch Histol Cytol. 1998;61(5):427-32.
Perra, M. T., Puxeddu, R., Maxia, C., & Sirigu, P. (1998). Immunohistochemical localization of secretory immunoglobulins in the main excretory duct of the human submandibular gland. Archives of Histology and Cytology, 61(5), 427-32.
Perra MT, et al. Immunohistochemical Localization of Secretory Immunoglobulins in the Main Excretory Duct of the Human Submandibular Gland. Arch Histol Cytol. 1998;61(5):427-32. PubMed PMID: 9990426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical localization of secretory immunoglobulins in the main excretory duct of the human submandibular gland. AU - Perra,M T, AU - Puxeddu,R, AU - Maxia,C, AU - Sirigu,P, PY - 1999/2/17/pubmed PY - 1999/2/17/medline PY - 1999/2/17/entrez SP - 427 EP - 32 JF - Archives of histology and cytology JO - Arch. Histol. Cytol. VL - 61 IS - 5 N2 - The localization of IgA, IgG, and IgM was investigated immunohistochemically in the mucosal surface of the main excretory duct of the human submandibular gland in order to verify the possible antimicrobial properties of this duct. Only secretory IgA-immunoreactivity was recognized in the epithelial cells of the duct. An intense immunoreactivity was observed in the cytoplasm of some cells and at the luminal surface of most of the cells. Clusters of IgA-positive immuno-competent cells were also recognizable in the subepithelial layers. No reactivity for IgG and IgM was noticed. The results suggest that the ductal epithelium may actively be involved in the release of secretory IgA, which could play a prominent role in the local defense mechanism of the duct. SN - 0914-9465 UR - https://www.unboundmedicine.com/medline/citation/9990426/Immunohistochemical_localization_of_secretory_immunoglobulins_in_the_main_excretory_duct_of_the_human_submandibular_gland_ DB - PRIME DP - Unbound Medicine ER -