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The neurobiology and pharmacotherapy of Alzheimer's disease.
J Neuropsychiatry Clin Neurosci. 1999 Winter; 11(1):19-31.JN

Abstract

Alzheimer's disease (AD), the most common cause of dementia, has become a major public health concern as our population ages. In recent years, AD has attracted the attention of a wide range of biological disciplines, and substantial progress has been made in understanding the mechanisms of neurodegeneration in AD. Four different genes have now been associated with AD and are providing insights into the pathogenesis of the disease. The roles of beta-amyloid, tau, hormonal changes, inflammation, and oxidative stress in the neurodegeneration of AD are also being delineated. Based on these discoveries, rational therapeutic strategies are developing rapidly. The authors review these and other recent advances in the neurobiology and pharmacotherapy of AD.

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Publisher Full Text

Authors+Show Affiliations

Felician O
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Sandson TA
No affiliation info available

MeSH

AcetylcholineAlzheimer DiseaseAmyloid beta-PeptidesApolipoproteins EBrainCholinergic FibersCholinesterase InhibitorsChromosomes, Human, Pair 19EstrogensHumansInflammationMicrotubulesModels, NeurologicalNeurofibrillary TanglesOxidative StressPlaque, Amyloid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9990552

Citation

Felician, O, and T A. Sandson. "The Neurobiology and Pharmacotherapy of Alzheimer's Disease." The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 11, no. 1, 1999, pp. 19-31.
Felician O, Sandson TA. The neurobiology and pharmacotherapy of Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 1999;11(1):19-31.
Felician, O., & Sandson, T. A. (1999). The neurobiology and pharmacotherapy of Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 11(1), 19-31.
Felician O, Sandson TA. The Neurobiology and Pharmacotherapy of Alzheimer's Disease. J Neuropsychiatry Clin Neurosci. 1999;11(1):19-31. PubMed PMID: 9990552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neurobiology and pharmacotherapy of Alzheimer's disease. AU - Felician,O, AU - Sandson,T A, PY - 1999/2/17/pubmed PY - 1999/2/17/medline PY - 1999/2/17/entrez SP - 19 EP - 31 JF - The Journal of neuropsychiatry and clinical neurosciences JO - J Neuropsychiatry Clin Neurosci VL - 11 IS - 1 N2 - Alzheimer's disease (AD), the most common cause of dementia, has become a major public health concern as our population ages. In recent years, AD has attracted the attention of a wide range of biological disciplines, and substantial progress has been made in understanding the mechanisms of neurodegeneration in AD. Four different genes have now been associated with AD and are providing insights into the pathogenesis of the disease. The roles of beta-amyloid, tau, hormonal changes, inflammation, and oxidative stress in the neurodegeneration of AD are also being delineated. Based on these discoveries, rational therapeutic strategies are developing rapidly. The authors review these and other recent advances in the neurobiology and pharmacotherapy of AD. SN - 0895-0172 UR - https://www.unboundmedicine.com/medline/citation/9990552/The_neurobiology_and_pharmacotherapy_of_Alzheimer's_disease_ L2 - https://neuro.psychiatryonline.org/doi/10.1176/jnp.11.1.19?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -