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Sodium loading of inner ear fluids.
Ann Otol Rhinol Laryngol 1976 Nov-Dec; 85(6 PT. 1):769-75AO

Abstract

A slow intracarotid infusion of hypertonic sodium chloride solution, 350 mEq/L, and potassium chloride, 5 mEq/L, was used to increase serum sodium chloride over a 90-minute period in 85 cats. A slow, steady rise in serum sodium occurred, which reached almost 208 mEq/L at the end of 90 minutes. A concomitant rise in sodium occurred in the cerebrospinal fluid and perilymph. In contrast, the sodium showed only a transient slight increase in the cochlear and vestibular endolymph. Endolymph potassium appeared to rise in order to balance out the increase in sodium concentration of the surrounding and extracellular fluids. The ratio of sodium to potassium ions in both the endolymph and perilymph compartment remained relatively constant before and after the infusion with hypertonic NaCl. After infusion, the total concentration of ions in endolymph was similar to that of perilymph. These experiments indicate that the endolymph compartment has a built-in mechanism for maintaining a low-sodium concentration while keeping ionic balance with the surrounding perilymph and serum.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

999141

Citation

Silverstein, H, and T Takeda. "Sodium Loading of Inner Ear Fluids." The Annals of Otology, Rhinology, and Laryngology, vol. 85, no. 6 PT. 1, 1976, pp. 769-75.
Silverstein H, Takeda T. Sodium loading of inner ear fluids. Ann Otol Rhinol Laryngol. 1976;85(6 PT. 1):769-75.
Silverstein, H., & Takeda, T. (1976). Sodium loading of inner ear fluids. The Annals of Otology, Rhinology, and Laryngology, 85(6 PT. 1), pp. 769-75.
Silverstein H, Takeda T. Sodium Loading of Inner Ear Fluids. Ann Otol Rhinol Laryngol. 1976;85(6 PT. 1):769-75. PubMed PMID: 999141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sodium loading of inner ear fluids. AU - Silverstein,H, AU - Takeda,T, PY - 1976/11/1/pubmed PY - 1976/11/1/medline PY - 1976/11/1/entrez SP - 769 EP - 75 JF - The Annals of otology, rhinology, and laryngology JO - Ann. Otol. Rhinol. Laryngol. VL - 85 IS - 6 PT. 1 N2 - A slow intracarotid infusion of hypertonic sodium chloride solution, 350 mEq/L, and potassium chloride, 5 mEq/L, was used to increase serum sodium chloride over a 90-minute period in 85 cats. A slow, steady rise in serum sodium occurred, which reached almost 208 mEq/L at the end of 90 minutes. A concomitant rise in sodium occurred in the cerebrospinal fluid and perilymph. In contrast, the sodium showed only a transient slight increase in the cochlear and vestibular endolymph. Endolymph potassium appeared to rise in order to balance out the increase in sodium concentration of the surrounding and extracellular fluids. The ratio of sodium to potassium ions in both the endolymph and perilymph compartment remained relatively constant before and after the infusion with hypertonic NaCl. After infusion, the total concentration of ions in endolymph was similar to that of perilymph. These experiments indicate that the endolymph compartment has a built-in mechanism for maintaining a low-sodium concentration while keeping ionic balance with the surrounding perilymph and serum. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/999141/Sodium_loading_of_inner_ear_fluids_ L2 - http://journals.sagepub.com/doi/full/10.1177/000348947608500606?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -