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(Annals of Neurology[TA])
11,058 results
  • Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. [Journal Article]
  • ANAnn Neurol 2018 Jun 16
  • Yu L, Petyuk VA, … Bennett DA
  • CONCLUSIONS: Using targeted proteomics, this work identified cortical proteins involved in Alzheimer's dementia and begins to dissect two different molecular pathways: one affecting β-amyloid deposition and another affecting resilience without a known pathologic footprint. This article is protected by copyright. All rights reserved.
  • Oligonucleotide therapy mitigates disease in Spinocerebellar Ataxia Type 3 mice. [Journal Article]
  • ANAnn Neurol 2018 Jun 16
  • McLoughlin HS, Moore LR, … Paulson HL
  • CONCLUSIONS: This preclinical study established efficacy of ATXN3-targeted ASOs as a disease-modifying therapeutic strategy for SCA3. These results support further efforts to develop ASOs for human clinical trials in this polyglutamine disease as well as in other dominantly inherited disorders caused by toxic gain of function. This article is protected by copyright. All rights reserved.
  • Filter-Probe Diffusion Imaging Improves Spinal Cord Injury Outcome Prediction. [Journal Article]
  • ANAnn Neurol 2018 May 11
  • Skinner NP, Lee SY, … Budde MD
  • CONCLUSIONS: Collectively, these results demonstrate FP-DDE benefits from greater specificity for acute axonal damage in predicting functional and histological outcomes with rapid acquisition and fully automated analysis, improving over standard DWI. FP-DDE is a promising technique compatible with clinical settings with potential research and clinical applications for evaluation of spinal cord pathology. This article is protected by copyright. All rights reserved.
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