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(Annals of Oncology[TA])
11,416 results
  • Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer. [Journal Article]
  • AOAnn Oncol 2018 Nov 13
  • Sokol ES, Feng YX, … Hartmaier RJ
  • CONCLUSIONS: This study identifies alteration of NF1 as enriched specifically in mILC. Mutual exclusivity with ESR1 alterations, polyclonality in relapsed ctDNA, and de novo acquisition suggest a role for NF1 loss in endocrine therapy resistance. Since NF1 loss leads to RAS/RAF kinase activation, patients may benefit from a matched inhibitor. Moreover, for an independent subset of mILC, TMB was elevated relative to breast ILC, suggesting possible benefit from immune checkpoint inhibitors.
  • Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2. [Journal Article]
  • AOAnn Oncol 2018 Oct 01; 29(10):2061-2067
  • Chang K, Willis JA, … Vilar E
  • CONCLUSIONS: Based on our observations made in premalignancy, we propose a model of pathway activation associated with CMS classification in colorectal carcinogenesis. Specifically, while adenomatous polyps are largely CMS2, most hyperplastic and serrated polyps are CMS1 and may transition into other CMS groups during evolution into carcinomas. Our findings shed light on the transcriptional landscape of premalignant colonic polyps and may help guide the development of future biomarkers or preventive treatments for CRC.
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