- Reopening schools in the context of increasing COVID-19 community transmission: The French experience. [Journal Article]
- CONCLUSIONS: In the context of increasing viral transmission in the population, the spread among children and adolescents remained lower than that observed among adults, despite keeping schools open. However, the impact was age-dependent, with data in high schools close to those observed in adults.
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- Unexplained near-drowning can reveal ALCAPA in children. [Journal Article]Arch Pediatr. 2021 Jan 22 [Online ahead of print]AP
- An 11-year-old girl experienced an episode of near-drowning. She was immediately rescued and was defibrillated. Transthoracic echocardiography and coronary computed tomographic angiography confirmed the diagnosis of anomalous left coronary artery from the pulmonary artery (ALCAPA). We report a rare description of this congenital coronary anomaly in a child, revealed after exercise-induced sudden …
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- Vitamin D intoxication due to misuse: 5-year experience. [Journal Article]Arch Pediatr. 2021 Jan 19 [Online ahead of print]AP
- CONCLUSIONS: Stoss therapy should not be administered for children of families with problems of adherence to treatment. It should be noted that VDI may develop as a result of improperly produced nutritional supplements. General practitioners and pediatricians must be aware of VDI risks and explain them to parents. Pamidronate is effective for treating VDI in children.
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- COVID-19 infection in children: A systematic review and meta-analysis of clinical features and laboratory findings. [Journal Article]
- CONCLUSIONS: This review found that clinical presentations were milder, the prognosis was better, and the mortality rate was lower in children with COVID-19 compared with adult patients; however, children are potential carriers, like adults, and can transmit the infection among the population. Therefore, early identification and intervention in pediatric patients with COVID-19 are essential in order to control the pandemic. Moreover, gastrointestinal symptoms were more common symptoms among children.
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- Are anxiety and the presence of siblings risk factors for dental neglect and oral health status in children? [Journal Article]Arch Pediatr. 2021 Feb; 28(2):123-128.AP
- CONCLUSIONS: The high level of dental anxiety and neglect in children with more than one sibling indicates that families should be more aware of the importance of oral health.
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- Bacteremia due to healthcare-associated urinary tract infections in children. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):147-149.AP
- CONCLUSIONS: The incidence of bacteremia associated with nosocomial urinary tract infections was not different from bacteremia associated with community-acquired urinary tract infections, and was approximately 5%.
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- Application of HAS 2017 guidelines for asymptomatic neonates born at ≥34 weeks' gestation at risk of early-onset neonatal sepsis in a level-2 maternity department. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):159-165.AP
- CONCLUSIONS: The HAS guidelines, emphasising repeated clinical assessment of newborns at risk of EONS rather than laboratory, were considered to be feasible in our maternity department. They led to an improvement in our professional practices and a reduction in laboratory procedures.
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- Term newborns at risk for early-onset neonatal sepsis: Clinical surveillance versus systematic paraclinical test. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):117-122.AP
- CONCLUSIONS: In this study, the application of the new guidelines enabled a reduction of antibiotic exposure and a reduction of invasive tests without additional risk.
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- Integrating a palliative approach into the healthcare provided by the French-African Pediatric Oncology Group's pilot units. Insights from a 3-year training program. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):166-172.AP
- Working alongside local stakeholders, members of the French-African Pediatric Oncology Group developed a 3-year program to train pediatric oncology teams from 15 French-speaking countries in Africa in using analgesics and providing palliative care. This program was rolled out in three phases: initial training, in situ assessment, and advanced training in selected topics. To access this program, m…
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- Coronavirus COVID-19 outbreak and control: Effect of temperature, relative humidity, and lockdown implementation. [Journal Article]
- Meteorological parameters are important factors that have an influence on infectious diseases. The present study aimed to explore the correlation between the spread of COVID-19, temperature, and relative humidity. The effect of human-imposed control parameters in the form of lockdown on the dissipation of COVID-19 was also analysed. Data were collected on the three study variables - temperature, …
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- Anxiety level and clinical course of patients with sickle cell disease during the COVID-19 outbreak. [Journal Article]
- CONCLUSIONS: These descriptive and correlation findings are the first reported on COVID-19-related anxiety in SCD patients. To develop screening and support strategies for mental health needs in pandemic times, further SCD studies should be conducted.
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- Time knowledge impairments in children with ADHD. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):129-135.AP
- CONCLUSIONS: This study shows time knowledge impairment in children with ADHD, and paves the way for new screening tests and rehabilitation focused on time knowledge and time-related skills, in order to improve patient care and autonomy.
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- Molecular diagnosis and genetic counseling for spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S9-7S14.AP
- Spinal muscular atrophy (SMA) is a neuromuscular autosomal recessive disorder caused by bi-allelic pathogenic variants in the SMN1 gene. 95% of SMA patients have a SMN1 homozygous deletion. In the 5% remaining affected patients, a heterozygous SMN1 deletion is associated with an intragenic SMN1 rare inactivating pathogenic variant on the other allele. The clinical phenotype of SMA is heterogeneou…
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- Ethical aspects in the care of a child with infantile spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S50-7S53.AP
- The pediatrician has a privileged relationship with a child with infantile spinal muscular atrophy (SMA). At all times, he/she must be the child's mentor, promoting a comprehensive approach and support in order to ensure the best possible solution for the patient's autonomy. In all circumstances, an ethical stance is essential. After a reminder on the notions of ethics of care, we will address va…
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- Multidisciplinary approach and psychosocial management of spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S45-7S49.AP
- Spinal Muscular Atrophy (SMA) is a severe complex disorder involving different aspects of care and professionals. Helping individuals to achieve their best possible quality of life is an essential part of health care. A multidisciplinary approach to management across the range of actors improves the function, quality of life and longevity of patients with SMA. Multidisciplinary management should …
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- State of the art for motor function assessment tools in spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S40-7S44.AP
- Spinal muscular atrophy (SMA) is a progressive disease characterized by a degeneration of the spinal cord motor neurons. Many clinical trials - planned, in progress, or completed - have chosen motor function as the primary or secondary outcome because motor function assessment tools appeared to be more reliable than quantitative muscle testing in monitoring the course of the disease. Reliable, va…
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- Functional and surgical treatments in patients with spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S35-7S39.AP
- Spinal muscular atrophies (SMA type 1, 2, 3) present with various severities according to the motor semeiology related to lesions of the peripheral nervous system (lesions of the anterior horn cells motoneuron or even brain stem). Early motor deficiency causes skeletal deformities responsible for the alteration or even absence of motor skills acquisition. The management of these patients involves…
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- Pathogenesis and therapeutic targets in spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S3-7S8.AP
- Autosomal-recessive spinal muscular atrophy (SMA) is characterized by the loss of specific motor neurons of the spinal cord and skeletal muscle atrophy. SMA is caused by mutations or deletions of the survival motor neuron 1 (SMN1) gene, and disease severity correlates with the expression levels of the nearly identical copy gene, SMN2. Both genes ubiquitously express SMN protein, but SMN2 generate…
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- Respiratory management of children with spinal muscular atrophy (SMA). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S29-7S34.AP
- Spinal muscular atrophy (SMA) causes a predominantly bilateral proximal muscle weakness and atrophy. The respiratory muscles are also involved with a weakness of the intercostal muscles and a relatively spared diaphragm. This respiratory muscle weakness translates into a cough impairment, resulting in poor clearance of airway secretions and recurrent pulmonary infections, restrictive lung disease…
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- Clinical features of spinal muscular atrophy (SMA) type 3 (Kugelberg-Welander disease). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S23-7S28.AP
- Spinal muscular atrophy type 3 (SMA3), also called Kugelberg-Welander SMA, typically presents with muscle fatigue, slowly progressive weakness and atrophy of lower limbs once they have already acquired independent ambulation. Visceral involvement frequent in type 1 and 2 subtypes is rare in SMA3. Hypotonia, hyperlaxity and absent osteo-tendinous reflexes are typical features. By definition, stand…
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- Clinical features of spinal muscular atrophy (SMA) type 2. [Review]Arch Pediatr. 2020 Dec; 27(7S):7S18-7S22.AP
- Infantile spinal muscular atrophy (SMA) type 2 is sometimes called intermediate SMA to indicate the disease severity. Generally, psychomotor development is normal until the age of 6 to 8 months, with the acquisition of a stable sitting position. The early signs are muscle weakness, mostly affecting the lower limbs, generalized hypotonia and areflexia. The consequences of motor neuron degeneration…
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- Spinal muscular atrophy (SMA) type I (Werdnig-Hoffmann disease). [Review]Arch Pediatr. 2020 Dec; 27(7S):7S15-7S17.AP
- Spinal muscular atrophy type I, also called Werdnig-Hoffmann disease, is the most serious form. The disease appears before the age of 6 months and is characterized by major global hypotonia and abolition of tendon reflexes, with children never being able to sit unaided. Cognitive development is normal and the expressive gaze of these children contrasts with the paralytic attitude. Respiratory inv…
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- Infantile spinal muscular atrophy (SMA). [Editorial]Arch Pediatr. 2020 Dec; 27(7S):7S1-7S2.AP
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- Clinical phenotype associated with TANGO2 gene mutation. [Journal Article]Arch Pediatr. 2021 Jan; 28(1):80-86.AP
- The clinical picture associated with a Transport and Golgi Organization 2 (TANGO2) gene bi-allelic mutation is represented by encephalopathy and rhabdomyolysis marked by cardiac rhythm disorders and neurological regression. The presentation of encephalopathy is diverse and can range from isolated language delay and cognitive impairment in a child to multiple disabilities and spastic quadriparesis…
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- Aeroallergen sensitisation patterns of children aged 5 years and younger with asthma and/or allergic rhinitis in Istanbul. [Journal Article]Arch Pediatr. 2021 Jan; 28(1):7-11.AP
- CONCLUSIONS: One out of every four atopic children aged 5 years or younger is sensitised to aeroallergens. The most common sensitisation is to house dust mites. Weed aeroallergen may be related to severity of asthma in children aged 5 years or younger in Istanbul. We speculate that HDM and weed allergens could be used in the diagnostic or treatment strategies for the management of asthmatic children aged 5 years or younger.
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- The phenotype caused by recessive variations in SLC25A22: Report of a new case and literature review. [Journal Article]Arch Pediatr. 2021 Jan; 28(1):87-92.AP
- We describe the clinical, electroencephalography (EEG), and developmental features of a patient with developmental and epileptic encephalopathy due to a homozygous pathogenic variation of mitochondrial glutamate/H+ symporter SLC25A22. Epilepsy began during the first week of life with focal onset seizures. Interictal EEG revealed a suppression-burst pattern with extensive periods of non-activity. …
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- Real-life study of the role of high-flow nasal cannula for bronchiolitis in children younger than 3 months hospitalised in general pediatric departments. [Journal Article]Arch Pediatr. 2021 Jan; 28(1):1-6.AP
- We aimed to describe the real-life role of high-flow nasal cannula (HFNC) for bronchiolitis in infants under 3 months of age admitted to three general pediatric departments during the 2017-2018 epidemic period. We retrospectively assessed the clinical severity (Wang score) for every 24-h period of treatment (H0-H24 and H24-H48) according to the initiated medical care (HFNC, oxygen via nasal cannu…
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- Oral manifestations of celiac disease in French children. [Journal Article]Arch Pediatr. 2021 Feb; 28(2):105-110.AP
- Celiac disease (CD) is an immune-mediated systemic disorder caused by ingestion of the gluten found in wheat, rye, and barley. The currently estimated prevalence in children is about 1%. CD is a chronic enteropathy with gastrointestinal manifestations including diarrhea, abdominal distension and weight loss, but extra-intestinal features are increasingly being reported. Dental and oral manifestat…
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- Respiratory and pharmacological management in severe acute bronchiolitis: Were clinical guidelines not written for critical care? [Journal Article]Arch Pediatr. 2021 Feb; 28(2):150-155.AP
- CONCLUSIONS: Our PICU did not follow the AAP recommendations. There were no differences between the two periods, except in the use of HFOT. All children older than 12 months received HFOT exclusively. The rate of using invasive mechanical ventilation was also low.
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- Primary juvenile hypothyroidism concurrent with huge bilateral cystic ovaries: Case report and literature review. [Journal Article]Arch Pediatr. 2021 Jan; 28(1):96-100.AP
- Primary hypothyroidism can lead to delayed growth and pseudoprecocious puberty in juvenile patients, which was known as Van Wyk-Grumbach's syndrome (VWGS). There have been very few clinical case reports of primary juvenile hypothyroidism presenting with concurrent huge bilateral cystic ovaries. Here, we report the case of a 14-year-old female patient suffering from primary hypothyroidism in combi…
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