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(Archives of Pathology and Laboratory Medicine[TA])
10,959 results
  • Human Papillomavirus Infection of the Skin. [Journal Article]
  • APArch Pathol Lab Med 2018; 142(6):700-705
  • Bacaj P, Burch D
  • CONCLUSIONS: - The use of low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion terminology brings order and simplicity to these lesions, correlates with the current understanding of the biology of human papillomavirus infections, and helps to promote accurate diagnosis of and appropriate treatment for these lesions.
  • Ocular Human Papillomavirus Infections. [Journal Article]
  • APArch Pathol Lab Med 2018; 142(6):706-710
  • Hanbazazh M, Gyure KA
  • CONCLUSIONS: - The low-risk HPV types 6 and 11 appear to play a role in the development of at least a subset of conjunctival squamous papillomas. The role of HPV in the pathogenesis of pterygium and ocular surface squamous neoplasia is less well defined. There is evidence to suggest that HPV may be a cofactor in the development of these lesions, acting in concert with ultraviolet radiation and/or human immunodeficiency virus infection in a subgroup of cases.
  • The Role of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma. [Journal Article]
  • APArch Pathol Lab Med 2018; 142(6):715-718
  • Ducatman BS
  • CONCLUSIONS: - The incidence of HPV-OPC is rising globally and in the United States, but rates of HPV-positivity vary with the anatomic site(s) and the population studied, as well as the method of detecting HPV infection. These tumors are more common in men. In contrast to HPV- OPC, the rates of smoking and alcohol abuse are lower. The HPV 16 subtype is predominant, and immunohistochemistry staining for p16 and in situ hybridization are the most widely used methods clinically to detect transcriptionally active HPV. Moreover, HPV-OPC has a unique tumor phenotype with predominantly nonkeratinizing morphology and a variety of patterns. These cancers often present with cystic lymph node metastases. The prognosis for HPV-OPC is significantly better than HPV- OPC and has led to differences in grading, staging, and management. Although there are similarities to cervical cancer, there are challenges in preventing such cancers.
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