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(Arthritis Research Therapy[TA])
3,989 results
  • Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes. [Journal Article]
  • ARArthritis Res Ther 2018 Apr 10; 20(1):67
  • Löfvall H, Newbould H, … Thudium CS
  • CONCLUSIONS: Our study supports that osteoclasts can resorb non-calcified and calcified cartilage independently of acidification. We demonstrated both MMP-mediated and cysteine protease-mediated resorption of calcified cartilage. Osteoclast functionality was highly dependent on the resorbed substrate, as different ECMs required different osteoclast processes for degradation. Our novel culture system has potential to facilitate drug and biomarker development aimed at rheumatic diseases, e.g. osteoarthritis, where pathological osteoclast processes in specific joint compartments may contribute to the disease process.
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