- 15 O-H2O PET/CT as a tool for the quantitative assessement of early post-radiotherapy changes of heart perfusion in breast carcinoma patients. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20170653
- CONCLUSIONS: 15O-H2O PET/CT is safe and effective for the early detection and quantitative analysis of subclinical post-radiotherapy changes in heart perfusion in breast cancer patients. The LV segments supplied by the LAD are the main site of MBF changes. A minimum radiation dose deposited in the LAD may be a predictor of radiation-induced heart toxicity. Advances in knowledge: This is the first time that 15O-H2O PET/CT has been used to assess MBF after radiotherapy and the first granular description of the distribution of blood flow changes after breast cancer radiotherapy.
- Application of 80-kVp scan and raw-data based iterative reconstruction for reduced iodine load abdominal-pelvic CT in patients at risk of contrast-induced nephropathy referred for oncological assessment: Effects on radiation dose, image quality and renal function. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20170632
- CONCLUSIONS: 80-kVp abdominal-pelvic CT with SAFIRE yields diagnostic image quality in oncology patients with renal dysfunction under substantially reduced iodine- and radiation dose without renal safety concerns. Advances in knowledge: Using 80-kVp and SAFIRE allows for 40% iodine load and 32% radiation dose reduction for abdominal-pelvic CT without compromising image quality and renal function in oncology patients at risk of contrast-induced nephropathy.
- Radiation repair models for clinical application. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20180070
- A number of newly-emerging clinical techniques involve non-conventional patterns of radiation delivery which require an appreciation of the role played by radiation repair phenomena. This review outl...
A number of newly-emerging clinical techniques involve non-conventional patterns of radiation delivery which require an appreciation of the role played by radiation repair phenomena. This review outlines the main models of radiation repair, focussing on those which are of greatest clinical usefulness and which may be incorporated into biologically effective dose (BED) assessments. The need to account for the apparent "slowing-down" of repair rates observed in some normal tissues is also examined, along with a comparison of the relative merits of the formulations which can be used to account for such phenomena. Jack Fowler brought valuable insight to the understanding of radiation repair processes and this article includes reference to his important contributions in this area.
- Doses from cervical spine computed tomography (CT) examinations in the UK. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20170834
- CONCLUSIONS: The rounded third quartile value of the mean dose distributions from this study were a CT dose index (CTDIvol) of 20 mGy and a dose-length product of 440 mGy cm as quoted for a 32 cm body phantom. These are significantly higher than those in the 2011 Public Health England CT dose survey when adjusted for phantom size. It is suggested that the existing national diagnostic reference levels for cervical spine CT should be amended, both with the new values and also to quote according to the 32 cm phantom. Advances in knowledge: Proposed new national diagnostic reference levels are presented for cervical spine CT examinations.
- Large datasets, logistics, sharing and workflow in screening. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20170751
- Cancer screening initiatives exist around the world for different malignancies, most frequently breast, colorectal, and cervical cancer. A number of cancer registries exist to collect relevant data, ...
Cancer screening initiatives exist around the world for different malignancies, most frequently breast, colorectal, and cervical cancer. A number of cancer registries exist to collect relevant data, but while these data may include imaging findings, they rarely, if ever, include actual images. Additionally, the data submitted to the registry are usually correlated with eventual cancer diagnoses and patient outcomes, rather than used with the individual's future screenings. Developing screening programs that allow for images to be submitted to a central location in addition to patient meta-data and used for comparison to future screening exams would be very valuable in increasing access to care and ensuring that individuals are effectively screened from year to year. It would also change the way imaging results and additional patient data are correlated to eventual outcomes. However, it introduces logistical challenges surrounding secure storage and transmission of data to subsequent screening sites. In addition, in the absence of standardized protocols for screening, comparing current and prior imaging, especially from different equipment, can be challenging. Implementing a large-scale screening program with an image-enriched screening registry-effectively, an image-enriched, electronic screening record-also requires that incentives exist for screening sites, physicians, and patients to participate; to maximize coverage, participation may have to be supported by government agencies. Workflows will also have to be adjusted to support registry participation for all screening patients in an effort to create a large, robust dataset that can be used for future screening efforts as well as research initiatives.
- A novel minimally invasive method of successful tissue glue injection in patients with iatrogenic pseudoaneurysm. [Journal Article]
- BJBr J Radiol 2018 Feb 22; :20170538
- CONCLUSIONS: Embolization of iatrogenic pseudoaneurysm using tissue glue seems to be an effective technique for the treatment of this complication. It might be considered as a treatment option in case of unsuccessful primary repair by means of thrombin injection orhemorrhagic shock due to rapid aneurysm progression. Advances in knowledge: Patients with multiple recanalizations and those with dynamically enlarging pseudoaneurysm or rapidly progressing anaemia are at risk of life-threatening bleeding. An ultrasound-guided tissue glue injection, a novel method for the treatment of femoral artery pseudoaneurysm, might be considered as a treatment option especially in case of primary thrombin injection failure.
- Quantitative analysis of enhanced malignant and benign lesions on contrast-enhanced spectral mammography. [Journal Article]
- BJBr J Radiol 2018 Feb 16; :20170605
- CONCLUSIONS: Despite variations in the degree of tumoural angiogenesis, quantitative analysis of the breast lesions on CESM documented the malignancies had distinctive stronger enhancement and depressed relative enhancement patterns than benign lesions. Advances in Knowledge: To our knowledge, this is the first study evaluating the feasibility of quantifying lesion enhancement on CESM. The quantities of enhancement were informative for assessing breast lesions in which the malignancies had stronger enhancement and more relative depressed enhancement than the benign lesions.
- Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study. [Journal Article]
- BJBr J Radiol 2018 Feb 16; :20170498
- CONCLUSIONS: This study provides proof of concept that molecular information can be derived from standard medical images and shows potential for radiomics as imaging biomarker of HPV status. Advances in knowledge: Radiomics has the potential to identify clinically relevant molecular phenotypes.
- Vacuum assisted breast biopsy (VAB) excision of subcentimeter microcalcifications as an alternative to open biopsy for atypical ductal hyperplasia. [Journal Article]
- BJBr J Radiol 2018 Feb 16; :20180003
- CONCLUSIONS: These results could justify the conservative management, in a selected group of patients, being the malignancy rate lower than 2%, considered in the literature as the "probably benign" definition. Advances in knowledge: Increasing the length of follow-up of selected patients conservatively managed can improve the management of ADH cases.
New Search Next
- Hepatocellular carcinoma surveillance with ultrasound-cost effectiveness, high-risk populations, uptake. [Journal Article]
- BJBr J Radiol 2018 Feb 15; :20170436
- Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and the second cause of cancer-related deaths worldwide. In most cases, it is diagnosed in patients with identified risk facto...
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and the second cause of cancer-related deaths worldwide. In most cases, it is diagnosed in patients with identified risk factors, mainly cirrhosis from all causes. These patients are candidates for a surveillance program that, depending on guidelines, involves regular liver ultrasound alone or combined with serum markers. These programs have been shown to improve the oncological outcome by detecting earlier stage tumors and providing patients with potentially curative treatment and improved survival. Yet, the level of evidence supporting these guidelines remain limited. This review article presents an overview of the evidence supporting surveillance programs for HCC, in particular the efficacy, cost-effectiveness, and consequences of this approach for patient survival. Western and Eastern guideline recommendations are described and discussed.