- Use of interventions involving virtual reality tasks during the climacteric: a systematic review. [Journal Article]Climacteric. 2022 Jun 30 [Online ahead of print]C
- Technological advances have been impacting health care worldwide. Our study aimed to research the literature systematically to determine the impact of technological treatments versus conventional treatments on the quality of life of climacteric women. The study was registered on PROSPERO (CRD42021241638). We searched seven databases, including PRISMA, using mesh terms. After screening for eligibi…
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- Effect of estrogen on vaginal complications of pessary use: a systematic review and meta-analysis. [Journal Article]Climacteric. 2022 Jun 13 [Online ahead of print]C
- CONCLUSIONS: Local estrogen in combination with a pessary could decrease the BV rate among postmenopausal women with POP. However, consensus regarding the value of estrogen use for decreasing other pessary complications has not yet been reached. Additional multicenter RCTs with large sample sizes should be conducted to better understand the effect of estrogen use on reducing pessary-related complications.
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- Resveratrol promotes bone mass in ovariectomized rats and the SIRT1 rs7896005 SNP is associated with bone mass in women during perimenopause and early postmenopause. [Journal Article]Climacteric. 2022 Jun 08 [Online ahead of print]C
- CONCLUSIONS: Resveratrol stimulated SIRT1 expression and Wnt/β-catenin signaling to promote bone mass in rat femurs. Among women in perimenopause and early postmenopause, SIRT1 protected bone mass, and the A allele of SIRT1 rs7896005 was a risk factor for reduced bone mass.
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- Relationship between the type of hormone replacement therapy and incidence of breast cancer in Korea. [Journal Article]Climacteric. 2022 Jun 08 [Online ahead of print]C
- CONCLUSIONS: For women in their 50s, tibolone use lowers BCR; for all ages, the use of any HRT for >5 years showed lower BCR in Korea. These divergent results from western countries could be associated with the specific characteristics of BC in Korea.
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- Effect of resistance training combined with β-glucan ingestion on bone of ovariectomized mice. [Journal Article]Climacteric. 2022 Jun 02 [Online ahead of print]C
- CONCLUSIONS: RT promoted benefits on bone health in the OVX model, which were not complemented by the consumption of BG.
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- Pilot study of women's perspectives when abnormal uterine bleeding occurs during perimenopause. [Journal Article]Climacteric. 2022 Jun 02 [Online ahead of print]C
- CONCLUSIONS: The experience of irregular or heavy vaginal bleeding during perimenopause is fraught with ambiguity, feelings of uncertainty about how to make sense of symptoms and inevitably begins with a period of self-appraisal.
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- Primary choice of estrogen and progestogen as components for HRT: a clinical pharmacological view. [Journal Article]Climacteric. 2022 May 31 [Online ahead of print]C
- Prescribing hormone replacement therapy (HRT) requires consideration of the selection of its two components, the estrogen and the progestogen. In terms of the estrogen, the decision is mainly whether to use estradiol (E2) or conjugated equine estrogens (CEE). These are the components needed to efficiently treat climacteric symptoms or/and prevent osteoporosis, currently the only labeled indicatio…
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- Plasma homocysteine levels and handgrip strength in postmenopausal women. [Journal Article]Climacteric. 2022 May 09 [Online ahead of print]C
- CONCLUSIONS: HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.
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- The promotion of menopausal hormone therapy might be determined by the attitude of health-care professionals. [Editorial]Climacteric. 2022 06; 25(3):213-214.C
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- First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency. [Journal Article]Climacteric. 2022 May 03 [Online ahead of print]C
- CONCLUSIONS: We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.
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- The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse. [Journal Article]Climacteric. 2022 Apr 20 [Online ahead of print]C
- CONCLUSIONS: No association was detected between rs2165241 of the Loxl1 gene and POP.
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- Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review. [Journal Article]Climacteric. 2022 Apr 19 [Online ahead of print]C
- Systemic lupus erythematosus (SLE) primarily affects women, who may need hormone therapy (HT) in menopause. There is, however, some concern as to its efficacy and safety. This systematic review aimed to determine the effect of HT on the activity of SLE and its safety. The study was a qualitative systematic review. Research was conducted with data retrieved from Embase, MEDLINE and Cochrane databa…
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- Menopausal hormone therapy: what are the problems in the perception of Chinese physicians? [Journal Article]Climacteric. 2022 Apr 19 [Online ahead of print]C
- CONCLUSIONS: Most Chinese physicians have basic knowledge of MHT. Their misunderstandings about MHT mainly centered on the risks of endometrial cancer, weight gain and the necessary examinations during follow-up visits. These misunderstandings need to be clarified in future professional training programs.
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- Ellen Theresia Maria Laan (April 3, 1962-January 22, 2022). [Journal Article]Climacteric. 2022 Jun; 25(3):316-318.C
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- Translation and validation of the Depression Anxiety Stress Scales for menopausal women in Indonesia. [Journal Article]Climacteric. 2022 Apr 14 [Online ahead of print]C
- CONCLUSIONS: This study's results indicated that the DASS-21 has satisfactory validity and reliability for detecting depression, anxiety and stress in menopausal women in Indonesia.
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- Efficacy of intradermal hyaluronic acid plus polynucleotides in vulvovaginal atrophy: a pilot study. [Journal Article]Climacteric. 2022 Apr 07 [Online ahead of print]C
- CONCLUSIONS: Vulvovaginal intradermal injection of PN/HA is a safe, effective treatment, is not expensive and is a reproducible procedure in postmenopausal women with VVA.
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- Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years? [Journal Article]Climacteric. 2022 Apr 06 [Online ahead of print]C
- CONCLUSIONS: The present study suggested an association between greater parasympathetic activation in women with more advanced climacteric status at the age of 46 years.
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- Skin, hair and beyond: the impact of menopause. [Journal Article]Climacteric. 2022 Apr 04 [Online ahead of print]C
- The skin is an endocrine organ and a major target of hormones such as estrogens, androgens and cortisol. Besides vasomotor symptoms (VMS), skin and hair symptoms often receive less attention than other menopausal symptoms despite having a significant negative effect on quality of life. Skin and mucosal menopausal symptoms include dryness and pruritus, thinning and atrophy, wrinkles and sagging, p…
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- A bibliometric analysis of primary ovarian insufficiency from 2010 to 2020. [Journal Article]Climacteric. 2022 Apr 04 [Online ahead of print]C
- CONCLUSIONS: This study might be the first bibliometric study to analyze publications of POI from multiple indicators, in order to provide new opinions for the research trends and possible hotspots of POI.
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- Vulvovaginal atrophy management with a laser: the placebo effect or the conditioning Pavlov reflex. [Journal Article]Climacteric. 2022 Mar 30 [Online ahead of print]C
- Postmenopausal vulvovaginal pain and atrophy require appropriate and sensitive outcomes that correlate with the genital discomfort, symptoms and expected changes. In some studies, hormone and laser treatments do not detect benefits due to the fact that appropriate measuring tools were not used. While some studies have demonstrated placebo effects for both therapeutic approaches, others support th…
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- Safety of prasterone in breast cancer survivors treated with aromatase inhibitors: the VIBRA pilot study. [Journal Article]Climacteric. 2022 Mar 28 [Online ahead of print]C
- CONCLUSIONS: Symptoms and physical examination regarding sexuality and vaginal health improved significantly, while serum estradiol remained at low levels. Prasterone seems a safe and effective option to treat GSM in BCS receiving AIs.
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- Women's health at midlife and beyond. [Editorial]Climacteric. 2022 04; 25(2):107-108.C
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- Impact of progesterone on the gastrointestinal tract: a comprehensive literature review. [Journal Article]Climacteric. 2022 Mar 07 [Online ahead of print]C
- Women are more prone to gastrointestinal symptoms than men. A comprehensive literature search was performed to assess the impact of sex steroid hormone, especially progesterone, on the (healthy and diseased) gastrointestinal tract. Overall, 37 articles were identified. Based on these we conclude that progesterone has a dose-dependent and sex-dependent effect on gastric emptying (especially in mam…
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- Menopausal hormone therapy: why we should no longer be afraid of the breast cancer risk. [Journal Article]Climacteric. 2022 Feb 11 [Online ahead of print]C
- The threat that women may develop breast cancer is the major reason why both physicians and women are afraid to use menopausal hormone therapy (MHT). The fear pertains to estrogen-progestin replacement therapy (EPRT) as estrogen-alone replacement therapy has no, or even a reduced, breast cancer risk. We reviewed the way breast cancer risk with EPRT was reported in some major publications since 20…
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- E2 + norethisterone promotes the PI3K-AKT pathway via PGRMC1 to induce breast cancer cell proliferation. [Journal Article]Climacteric. 2022 Feb 09 [Online ahead of print]C
- CONCLUSIONS: CK2 is involved in phosphorylation of PGRMC1 at S181. The mechanism for the action of PGRMC1 for mediating proliferative progestogen effects obviously starts with promotion cell cycle regulation, and then activation of the PI3K-AKT pathway.
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- The impact of micronized progesterone on cardiovascular events - a systematic review. [Journal Article]Climacteric. 2022 Feb 03 [Online ahead of print]C
- Biologically identical menopausal hormone therapy (MHT) including micronized progesterone (MP) has gained much attention. We aimed to assess the impact of MP in combined MHT on venous and arterial thromboembolism (VTE/ATE) (e.g. deep venous thrombosis/pulmonary embolism, myocardial infarction [MI] and ischemic stroke). Articles were eligible if they provided endpoints regarding cardiovascular eve…
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- Relation between blood pressure and genito-urinary symptoms in the years across the menopausal age. [Journal Article]Climacteric. 2022 Jan 20 [Online ahead of print]C
- CONCLUSIONS: In women across the menopausal age, genito-urinary symptoms, more than HF, are associated with higher values of SBP, DBP, heart rate and hypertension.
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- Bone health 2022: an update. [Editorial]
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- Short-term effects of an erbium/neodymium laser combination in superficial dyspareunia: a pilot study. [Journal Article]
- CONCLUSIONS: The addition of Nd:YAG to VEL may induce greater improvement in superficial dyspareunia in PMW with GSM.
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- Alterations of regional homogeneity in perimenopause: a resting-state functional MRI study. [Journal Article]Climacteric. 2022 Jan 07 [Online ahead of print]C
- CONCLUSIONS: Changes in abnormal patterns of the ReHo in perimenopausal women affect cognitive function. These changes in brain function may provide more insights and information on the neural mechanisms of cognitive dysfunction in perimenopausal women.
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