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2,098 results
  • Postmenopausal hyperandrogenism. [Journal Article]
    Climacteric. 2021 May 14 [Online ahead of print]Yoldemir T
  • Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, physicians must exclude the possibility…
  • Estradiol selectively regulates metabolic substrates across memory systems in models of menopause. [Journal Article]
    Climacteric. 2021 May 13 [Online ahead of print]Prakapenka AV, Korol DL
  • Estrogen loss at menopause is thought to contribute to specific memory problems commonly encountered by women who are transitioning through or who have experienced menopause. Work in preclinical models suggests that estrogens bidirectionally regulate cognition through direct actions on different neural systems called memory systems, enhancing some types of learning and memory while impairing othe…
  • The role of medications in successful aging. [Journal Article]
    Climacteric. 2021 May 12 [Online ahead of print]Langer RD
  • Successful aging includes good health and low levels of disability. To that end, primary prevention is far better than managing subsequent organ damage. When medication is needed to prevent or manage disease, the preferred choice should be associated with the greatest benefits and fewest adverse effects. Cardiovascular diseases are the leading cause of morbidity and mortality in postmenopausal wo…
  • Menopause, hormone therapy and cognition: maximizing translation from preclinical research. [Journal Article]
    Climacteric. 2021 May 12 [Online ahead of print]Bimonte-Nelson HA, Bernaud VE, Koebele SV
  • Menopause-associated and hormone-associated cognitive research has a rich history built from varied disciplines and species. This review discusses landmark rodent and human work addressing cognitive outcomes associated with varied experiences of menopause and hormone therapy. Critical variables in menopause and cognitive aging research are considered, including menopause etiology, background horm…
  • New insights into the diagnosis and management of bone health in premature ovarian insufficiency. [Journal Article]
    Climacteric. 2021 May 06 [Online ahead of print]Nguyen HH, Milat F, Vincent AJ
  • Premature ovarian insufficiency (POI), defined as a loss of ovarian function before the age of 40 years, is a life-changing diagnosis that has numerous long-term consequences. Musculoskeletal complications, including osteoporosis and fractures, are a key concern for women with POI. The risk of bone loss is influenced by the underlying etiology of POI, and the degree and duration of estrogen defic…
  • Premature ovarian insufficiency: the need for evidence on the effectiveness of hormonal therapy. [Journal Article]
    Climacteric. 2021 Apr 30 [Online ahead of print]Upton CE, Daniels JP, Davies MC
  • Premature ovarian insufficiency (POI) - the loss of ovarian function before the age of 40 years, a decade before natural menopause - is a life-changing diagnosis for women. POI causes significant short-term and long-term morbidity related to estrogen deficiency. The condition is managed by providing exogenous estrogen replacement, usually as the oral contraceptive pill or hormone therapy. These p…
  • Hyaluronic acid in vulvar and vaginal administration: evidence from a literature systematic review. [Journal Article]
    Climacteric. 2021 Mar 24 [Online ahead of print]Buzzaccarini G, Marin L, … Ambrosini G
  • Vulvovaginal pathology impairs the quality of life of both women in menopause and those who are not. Different therapies have been proposed, mainly related to estrogen therapy in postmenopausal women. However, some contraindications limit its use, and different moisturizers or lubricants have been tested. Hyaluronic acid is a promising and widely used vaginal medical treatment with a moisturizing…
  • Premature or early bilateral oophorectomy: a 2021 update. [Journal Article]
    Climacteric. 2021 Mar 15 [Online ahead of print]Rocca WA, Mielke MM, … Stewart EA
  • In this invited review, we discuss some unresolved and controversial issues concerning premature (<40 years) or early (40-45 years) bilateral oophorectomy. First, we clarify the terminology. Second, we summarize the long-term harmful consequences of bilateral oophorectomy. Third, we discuss the restrictive indications for bilateral oophorectomy in premenopausal women to prevent ovarian cancer tha…
  • Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline? [Journal Article]
    Climacteric. 2021 Mar 15 [Online ahead of print]Reuben R, Karkaby L, … Einstein G
  • Subjective cognitive decline (SCD) and the loss of ovarian hormones after menopause have been independently linked to later-life Alzheimer's disease (AD). The objective of this review was to determine whether menopause and the loss of ovarian hormones contribute to cognitive complaints and SCD in women. This would suggest that SCD at the menopausal transition might be an important marker of event…
  • Sustainability of vaginal estrogens for genitourinary syndrome of menopause - a systematic review. [Journal Article]
    Climacteric. 2021 Mar 12 [Online ahead of print]Weidlinger S, Schmutz C, … Stute P
  • Genitourinary syndrome of menopause (GSM) is a highly prevalent, not self-limiting condition displaying a major negative impact on sexual function and emotional well-being. Various non-hormonal and hormonal treatment options are available. Many women consider GSM treatment to be a short-term interval cure rather than a long-term or lifelong treatment. The aim of this systematic literature search …
  • A review of the impact of hormone therapy on prefrontal structure and function at menopause. [Journal Article]
    Climacteric. 2021 Mar 11 [Online ahead of print]Li Y, Dreher JC
  • The menopause transition arises mainly from a decline in ovarian function characterized by a decrease in levels of ovarian estrogens (estradiol) and progesterone in women. Menopausal hormone therapy (MHT) has been used to counteract menopause-associated symptoms in postmenopausal women. With the development of advanced brain imaging methods, understanding MHT-related effects on brain structures a…
  • Genitourinary syndrome of menopause in Chinese perimenopausal and postmenopausal women. [Journal Article]
    Climacteric. 2021 Jun; 24(3):297-304.Ruan X, Zhang L, … Mueck AO
  • CONCLUSIONS: Within 2 years, more than 4000 women with GSM traveled from all over China to our specialized clinic, indicating the great importance of GSM. Hysterectomy can increase the risk of GSM, and GSM symptoms increase from perimenopause to postmenopause and with an increase of time since menopause, pointing to the dependency on the loss of ovarian function.
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