- Cytokine-involved phenotyping identifies a high-risk inflammatory cluster in treatment-naïve Takayasu's arteritis. [Journal Article]Clin Exp Rheumatol. 2026 Oct 16. [Online ahead of print]CE
- CONCLUSIONS: Cytokine-involved phenotyping may provide a preliminary framework for risk stratification in treatment-naïve TAK. The multiplex cytokine activation phenotype appears to be associated with adverse clinical outcomes, although further validation in larger cohorts is required.
- Publisher Full Text (DOI)
- Association between serum transaminase elevations and clinical course in patients with familial Mediterranean fever. [Journal Article]Clin Exp Rheumatol. 2026 Oct 15. [Online ahead of print]CE
- CONCLUSIONS: Elevated serum transaminase levels can be detected in approximately 11.2% of FMF patients, and this finding is not associated with colchicine use or manifestations of FMF. Ultrasonographic evidence of hepatosteatosis was observed in nearly half of the patients. Follow-up analysis showed that serum transaminase elevations may persist in 43% of the patients, which suggests further studies to determine whether this abnormality is a feature of FMF or not.
- Publisher Full Text (DOI)
- Damage accrual predicts the development of lymphoma in primary Sjögren's disease. [Journal Article]Clin Exp Rheumatol. 2026 Oct 16. [Online ahead of print]CE
- CONCLUSIONS: Although damage was not associated with mortality, age at diagnosis and onset of symptoms were risk factors for mortality in pSjD. Cumulative and evolving damage, especially in the first years of disease, should raise concern about the possible development of lymphoma in these patients.
- Publisher Full Text (DOI)
- Utility of follow-up cardiac magnetic resonance imaging in patients with eosinophilic granulomatosis with polyangiitis. [Journal Article]Clin Exp Rheumatol. 2026 Oct 02. [Online ahead of print]CE
- CONCLUSIONS: The role of CMRIs to study and monitor cardiac involvement in EGPA remains unclear. LGE most often persists despite treatment, with no apparent association with adverse cardiac outcomes in this cohort.
- Publisher Full Text (DOI)
- Lung ultrasound as part of a diagnostic algorithm to detect interstitial lung disease in rheumatoid arthritis patients at risk. [Journal Article]Clin Exp Rheumatol. 2026 Oct 14. [Online ahead of print]CE
- CONCLUSIONS: Negative LUS in combination with normal DLCO reliably exclude ILD in at-risk RA patients, supporting its role in early RA-ILD detection.
- Publisher Full Text (DOI)
- Reply to the comment on: Clinical impact of anti-SSA antigenic specificity on disease activity and patient-reported outcomes in primary Sjögren's disease: a real-life cohort study. [Letter]Clin Exp Rheumatol. 2026 Oct 06. [Online ahead of print]CE
- Publisher Full Text (DOI)
- Comment on: Clinical impact of anti-SSA antigenic specificity on disease activity and patient-reported outcomes in primary Sjögren's disease: a real-life cohort study. [Letter]Clin Exp Rheumatol. 2026 Oct 06. [Online ahead of print]CE
- Publisher Full Text (DOI)
- Incorporation of patient-reported outcomes in the clinical risk score to improve relapse prediction in ANCA-associated vasculitis. [Journal Article]Clin Exp Rheumatol. 2026 Oct 02. [Online ahead of print]CE
- CONCLUSIONS: The first-year cumulative SF-36 PCS was independently associated with relapse in patients with MPA or GPA, and its integration with the FRS improved relapse risk prediction. These findings support a multidimensional approach incorporating both clinical and patient-reported data to better stratify relapse risk and inform treatment planning in MPA or GPA.
- Publisher Full Text (DOI)
- Serum advanced glycation end products and glyoxalase-1 levels in Behçet's disease: a cross-sectional study. [Journal Article]Clin Exp Rheumatol. 2026 Oct 07. [Online ahead of print]CE
- CONCLUSIONS: Elevated levels of advanced glycation end products and decreased glyoxalase-1 levels were observed in BD. This pattern suggests that the inflammatory process in BD may be associated with AGE accumulation and attenuation of protective antioxidant/dicarbonyl-detoxification pathways. Elevated AGEs may contribute to the pathogenesis of atherosclerosis in individuals with BD.
- Publisher Full Text (DOI)
- Immune responses targeting homocitrullinated peptides drive rheumatoid arthritis-like pathology in HLA-DR4 transgenic mice. [Journal Article]Clin Exp Rheumatol. 2026 Oct 06. [Online ahead of print]CE
- CONCLUSIONS: Homocitrulline-specific immune responses can induce RA-like disease in DR4tg mice, supporting the pathogenic role of AHCPAs in RA.
- Publisher Full Text (DOI)
- AA amyloidosis as a rare presentation leading to the diagnosis of mevalonate kinase deficiency in a male adult: a diagnostic challenge mimicking familial Mediterranean fever. [Letter]Clin Exp Rheumatol. 2026 Oct 09. [Online ahead of print]CE
- Publisher Full Text (DOI)
- Effectiveness, survival and prescription patterns of Janus kinase inhibitors in rheumatoid arthritis: results of a 5.9-year follow-up from the Italian Study Group of Early Arthritis (GISEA) registry. [Journal Article]Clin Exp Rheumatol. 2026 Oct 14. [Online ahead of print]CE
- CONCLUSIONS: This large real-world study confirms the effectiveness of JAKis in RA, with valuable insights into factors influencing treatment survival and evolving prescription trends.
- Publisher Full Text (DOI)
- Multifactorial explanatory model of self-reported sleep disturbance in people with rheumatoid arthritis: a structural equation approach. [Journal Article]Clin Exp Rheumatol. 2026 Oct 06. [Online ahead of print]CE
- CONCLUSIONS: 'Positive' personality traits and perceived disease impact appear to be significantly associated with self-reported sleep disturbance in RA patients, while disease activity, depression, and anxiety showed comparatively smaller associations within the model. These findings support the need for a holistic, multidisciplinary approach to RA management.
- Publisher Full Text (DOI)
- Factors associated with chronic kidney disease in patients with gout: a two-centre study incorporating ultrasonographic features. [Journal Article]Clin Exp Rheumatol. 2026 Oct 06. [Online ahead of print]CE
- CONCLUSIONS: We established an interpretable analytical framework that characterises the clinical and ultrasonographic profile associated with CKD in gout. By integrating imaging markers with clinical indicators, this approach identifies associated phenotypes, providing a transparent reference for individualised assessment and enhanced clinical vigilance regarding renal status.
- Publisher Full Text (DOI)
- Therapeutic divergence between polymyalgia rheumatica and giant cell arteritis: lessons from IL-17A inhibition. [Editorial]Clin Exp Rheumatol. 2026 Oct 14. [Online ahead of print]CE
- Publisher Full Text (DOI)