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(Clinical Toxicology[TA])
4,804 results
  • Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats. [Journal Article]
  • CTClin Toxicol (Phila) 2018 Oct 11; :1-7
  • Marquart K, Herbert J, … Wille T
  • CONCLUSIONS: The current in vivo study did not confirm concerns of altered potency of existing anaesthetic protocols for the application of propofol or thiopental with fentanyl due to soman poisoning. Despite severe cholinergic crisis, sufficient anaesthetic depth could be achieved in all animals.Further experiments in in vivo models closer to human pharmaco- and toxicokinetics (e.g., swine) are required for confirmation of the initial findings and for improving extrapolation to humans.
  • Interpreting γ-hydroxybutyrate concentrations for clinical and forensic purposes. [Journal Article]
  • CTClin Toxicol (Phila) 2018 Oct 11; :1-15
  • Busardò FP, Jones AW
  • CONCLUSIONS: Body fluids for the analysis of GHB must be obtained as quickly as possible after a poisoned patient is admitted to hospital or after a person is arrested for a drug-related crime to enhance chances of detecting the drug. The sampling of urine lengthens the window of detection by 3-4 h compared with blood samples, but with longer delays between last intake of GHB and obtaining specimens, hair strands, and/or nails might be the only option. In postmortem toxicology, the concentrations of drugs tend to be more stable in bladder urine, VH, and CSF compared with blood, because these sampling sites are protected from the spread of bacteria from the gut. Accordingly, the relationship between blood and urine concentrations of GHB furnishes useful information when drug intoxication deaths are investigated.
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