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(Curr Opin Clin Nutr Metab Care[TA])
2,197 results
  • Determinants of amino acid bioavailability from ingested protein in relation to gut health. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 21 [Online ahead of print]Gaudichon C, Calvez J
  • CONCLUSIONS: The past 5 years have seen a renewed interest in amino acid bioavailability in view of assessing protein quality to support current shifts in protein sourcing. Methodological developments have been performed and several studies have reported values in various models. The question of protein digestibility in gut disorders remains poorly addressed.
  • Emerging roles of bile acids in control of intestinal functions. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 16 [Online ahead of print]Yang J, Palmiotti A, Kuipers F
  • CONCLUSIONS: Specific bile acids act as important signalling molecules affecting whole body metabolism, specific transport processes and immunity in different segments of the intestinal tract. Their relevance for human (patho)physiology is emerging. Novel mouse models with human-like bile acid composition will aid to accelerate translational research.
  • Protein and amino acids in nonalcoholic fatty liver disease. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 16 [Online ahead of print]Tricò D, Biancalana E, Solini A
  • CONCLUSIONS: Mechanistic studies in NAFLD have been mostly focused on carbohydrate and fat metabolism, while little is known about the influence of protein and amino acids. Moreover, intervention and observational studies on the relation between protein intake and NAFLD yielded conflicting results. Filling the current knowledge gaps would help define the optimal diet composition for NAFLD prevention and management. Furthermore, metabolomics studies may provide insight into the pathogenesis of NAFLD, identify useful diagnostic and prognostic biomarkers, and unravel novel pharmacological targets and treatment options.
  • Inherited disorders of sulfur amino acid metabolism: recent advances in therapy. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 16 [Online ahead of print]Kožich V, Majtan T
  • CONCLUSIONS: Complex regulation of pathways involved in SAA metabolism and cellular consequences of genetic defects in SAA metabolism are only partially understood. There is a pressing need to increase substantially our knowledge of the disease mechanisms to develop more effective therapies for patients suffering from these rare disorders.
  • Essential amino acid formulations to prevent mitochondrial dysfunction and oxidative stress. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 16 [Online ahead of print]Ruocco C, Segala A, … Nisoli E
  • CONCLUSIONS: EAA-BCAA balanced supplements might be valuable not only for healthy individuals undergoing to energy deficit (e.g., athletes or military personnel) during strenuous exercise or training but also against diseases characterized by a dysregulated catabolic state or mitochondrial dysfunction, such as age-related disorders. The associated mechanistic processes should be identified as potential pharmacological targets.
  • Dietary protein interventions to improve nutritional status in end-stage renal disease patients undergoing hemodialysis. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Oct 27 [Online ahead of print]Hendriks FK, Kooman JP, van Loon LJC
  • CONCLUSIONS: A coordinated program that combines nutritional and physical activity interventions is likely required to attenuate the decline in muscle mass and strength of chronic hemodialysis patients. Nephrologists, dieticians, and exercise specialists should collaborate closely to establish guidelines regarding the appropriate quantity and timing of protein ingestion. In addition, they should provide tailored nutritional and physical activity interventions for chronic hemodialysis patients (see video, Supplemental Digital Content 1, Video abstract,
  • A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Sep 29 [Online ahead of print]Cereda E, Bogliolo L, … Caccialanza R
  • CONCLUSIONS: Speculative hypotheses and observational data have suggested a protective role of vitamin D in COVID-19. However, many unanswered questions remain, aberrant detrimental effects of adequate vitamin D25OH levels cannot be excluded and whether its adequacy may prevent the infection or improve clinical outcomes needs to be assessed by adequately sized and designed population-based studies and intervention trials.
  • Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Sep 15 [Online ahead of print]Biesalski HK
  • CONCLUSIONS: There is a direct relationship between vitamin D, body fat and age in COVID-19 courses. With age, the ability of the skin to synthesize vitamin D decreases, and leads to vitamin D-deficits. If the skin is insufficiently exposed to sunlight, severe deficits can develop. As vitamin D plays an important role not only in the immune system but also in the RAS, and thus at the point where the virus attacks, a good vitamin D supply is an important basis for reducing the risk of severe COVID-19 processes. Treatment with vitamin D supplements should be based on severity of the vitamin D deficiency.
  • Dietary fibers reduce obesity-related disorders: mechanisms of action. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):445-450.Dayib M, Larson J, Slavin J
  • CONCLUSIONS: Dietary fiber prevents and treats obesity-related disorders. Mechanisms for this protection include decreased absorption of macronutrients and enhanced satiety. Changes in the gut microbiota and short-chain fatty acids are emerging mechanisms to explain why high fiber diets protect against obesity and have a role in obesity treatment.
  • Can nicotinamide riboside protect against cognitive impairment? [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):413-420.Braidy N, Liu Y
  • CONCLUSIONS: Oral nicotinamide riboside may represent a promising stratagem to improve cognitive decline during 'normal' ageing, Alzheimer's disease and other diseases. Results from recent clinical trials are needed to enumerate the preclinical benefits in humans.
  • Dietary lipids and cardiometabolic health: a new vision of structure-activity relationship. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):451-459.Vors C, Le Barz M, … Michalski MC
  • CONCLUSIONS: These findings open new clinical research questions aiming to further characterize the cardiometabolic fate of lipids, from digestion to bioactive metabolites, according to the food source or molecular carrier. This should be useful to elaborate food formulations for target populations and personalized dietary recommendations.
  • Intermittent fasting as a nutrition approach against obesity and metabolic disease. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):387-394.Zhu S, Surampudi P, … Chondronikola M
  • CONCLUSIONS: Intermittent fasting is a promising nutritional approach against obesity and its related metabolic diseases. Further research is needed to: i) establish the long-term effectiveness of TRE in weight loss and metabolic health, ii) improve the long-term adherence to ADF and investigate its weight loss independent effects in metabolic health, and iii) determine the mechanisms underlying the potential cardiometabolic benefits of intermittent fasting in humans.
  • Current mechanisms in obesity and tumor progression. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):395-403.Fosam A, Perry RJ
  • CONCLUSIONS: This review will highlight the present understanding of obesity, as it relates to tumor development and progression. First, we will introduce the impact of obesity in cancer within the dynamic tumor microenvironment, which will serve as a theme to frame this review. The core of this review will discuss recently proposed mechanisms that implicate obesity in tumor progression, including chronic inflammation and the role of pro-inflammatory cytokines, adipokines, hormones, and genetic approaches. Furthermore, we intend to offer current insight in targeting adipose tissue during the development of cancer prevention and treatment strategies.
  • Dietary protein intake and obesity-associated cardiometabolic function. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):380-386.Fappi A, Mittendorfer B
  • CONCLUSIONS: The relationship between protein intake and cardiometabolic health is complex and influenced by concomitant changes in body weight and overall diet composition. Although a high-protein, low-carbohydrate, reduced-energy diet can have beneficial effects on body weight and plasma glucose, habitual high-protein intake, without marked carbohydrate and energy restriction, is associated with increased cardiometabolic disease risk, presumably mediated by the changes in the hormonal milieu after high-protein intake.
  • Lifestyle interventions affecting hepatic fatty acid metabolism. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):373-379.Parry SA, Turner MC, Hodson L
  • CONCLUSIONS: Lifestyle interventions represent an effective means of influencing hepatic fatty acid metabolism. IHTG content is decreased without weight-loss either through exercise or by changing the macronutrient composition of the diet, although what the optimal macronutrient composition is to achieve this has yet to be defined.
  • Recent advances in clinical probiotic research for sport. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Nov; 23(6):428-436.Jäger R, Mohr AE, Pugh JN
  • CONCLUSIONS: The current body of literature highlights the specificity of probiotic strain/dose and potential mechanisms of action for application in sport. These novel findings open new areas research, potential use for human health, and reinforce the potential role for probiotic's in exercise performance. While encouraging, more well designed studies of probiotic supplementation in various sport applications are warranted.
  • The 6 Ps of post-ICU recovery: application of a shared conceptual model. [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Sep; 23(5):367-372.Jones JRA, Griffith DM
  • CONCLUSIONS: A structured approach to clinical practice and future research to better understand the mechanism (Problem), and identify Predisposing, Precipitating and Perpetuating risk factors will advance the field in better managing ICU-AW through implementation of Protective strategies and Proactive multimodal treatments.
  • Assessment of energy expenditure: are calories measured differently for different diets? [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Sep; 23(5):312-318.Sanchez-Delgado G, Ravussin E
  • CONCLUSIONS: Although energy expenditure and macronutrient oxidation can be assessed by simple calculations from oxygen consumption and carbon dioxide production, these calculations can provide erroneous results or require corrections and/or more complex interpretation when several biochemical pathways are simultaneously engaged. Such physiological mechanisms are often elicited by dietary interventions including, among other, gluconeogenesis, lipogenesis, ketogenesis, alcohol oxidation and under or overfeeding.
  • When to use probiotics in luminal gastrointestinal disorders? [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Sep; 23(5):336-343.Elangovan A, Fischer M
  • CONCLUSIONS: Despite burgeoning body of literature and wide acceptance by the public, a thorough understanding of efficacy and safety of probiotics is lacking. Uniform dosage, standardized clinical end points, personalization based on host microbial profile and longer duration of follow-up on the research front may help in the future in appropriate positioning of probiotics in health and disease.
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