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(Current opinion in organ transplantation[TA])
1,015 results
  • Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. [Journal Article]
  • COCurr Opin Organ Transplant 2017 Jan 11
  • Trunečka P
  • CONCLUSIONS: Pharmacokinetic differences between TAC BID and Advagraf translate into less interpatient and intrapatient variability and improve adherence. If survival benefit of Advagraf administration de novo after LTx as demonstrated by the European Liver Transplant Registry analysis is confirmed in an independent cohort, Advagraf will leave the area of the 'me-too' drugs to become the immunosuppressant of choice.
  • Antibody-mediated rejection: what is the clinical relevance? [Journal Article]
  • COCurr Opin Organ Transplant 2017 Jan 03
  • Hogen R, DiNorcia J, Dhanireddy K
  • CONCLUSIONS: AMR has evolved into an established pathology in OLT recipients. Acute AMR may lead to early graft loss whereas chronic AMR results in progressive fibrosis if unrecognized. DSAs, likely in the setting of predisposing environmental factors, appear to play a role in T cell-mediated rejection and long-term graft outcomes.
  • The case against imminent death donation. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Dec 26
  • Lee GS, Potluri VS, Reese PP
  • CONCLUSIONS: Although IDD has been proposed as a method to increase the number of organs or improve end-of-life care, the proposal currently poses more risk than benefit for patients and the transplant community. Until the major barriers to implementation of IDD are addressed, the transplant community should invest its efforts to increase the organ supply elsewhere.
  • Outcomes and disparities in liver transplantation will be improved by redistricting-cons. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Dec 26
  • Goldberg DS, Karp S
  • CONCLUSIONS: This review article highlights major methodological and policy flaws with the current redistribution proposal. We demonstrate how the waitlist disparities that the proposal is intended to fix are not as they seem. Furthermore, if this proposal is passed, outcomes of liver transplantation nationally may worsen, and disparities for those with limited access to healthcare will worsen.
  • Organ donation and imminent death: pro position. [Journal Article]
  • COCurr Opin Organ Transplant 2016 Dec 23
  • Morrissey PE
  • CONCLUSIONS: This review, on the 'Pro' side of IDD, proposes that the medical community continue to work toward implementing IDD. Donor family's wishes are best met by organ donation, successful outcomes for the recipients, and a dignified death for their loved one. In some cases, IDD is the best strategy to meet these goals.
  • Polyreactive natural antibodies in transplantation. [Journal Article]
  • COCurr Opin Organ Transplant 2017; 22(1):8-13
  • Zorn E, See SB
  • CONCLUSIONS: In conclusion, Nabs are important elements in host immune responses to solid organ grafts. The recent description of their implication in ABMR and late kidney graft loss warrants further investigation into their pathogenic potential.
  • Impact of hyperlipidemia on alloimmunity. [Journal Article]
  • COCurr Opin Organ Transplant 2017; 22(1):14-21
  • Bagley J, Yuan J, Iacomini J
  • CONCLUSIONS: These findings highlight the importance of considering the contribution of inflammatory comorbidities to cardiac allograft rejection, and point to the potential importance of managing hyperlipidemia in the transplant population.
  • Mechanisms of liver-induced tolerance. [Journal Article]
  • COCurr Opin Organ Transplant 2017; 22(1):71-78
  • Moris D, Lu L, Qian S
  • CONCLUSIONS: The research during last year offered some key insights into the mechanisms of liver-induced tolerance. Through interactions with activated T cells and B cells via IFN-γ/B7-H1 pathways, liver mesenchymal cells have been shown to be critical components of liver-specific tolerance induction.
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