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(Current pharmaceutical design[TA])
6,682 results
  • Agaricus blazei bioactive compounds and their effects on human health: benefits and controversies. [Journal Article]
  • CPCurr Pharm Des 2017 Jan 18
  • da Silva de Souza AC, Correa VG, … Peralta RM
  • CONCLUSIONS: The amount and quality of the evidence that has been accumulating during the last decade strongly speaks in favor of the health benefits of the ingestion of A.blazei or derived products. However, there are many uncertainties and limitations when attempts are made to extrapolate or to demonstrate their biological effects in the human organism in health or disease. Clearly, more clinical trials, using reliable statistical methods and standardized preparations are needed to establish the efficacy of A. blazei as a therapeutic agent.
  • Traumatic brain injury: preclinical imaging diagnostic(s) and therapeutic approaches. [Journal Article]
  • CPCurr Pharm Des 2017 Jan 16
  • Kaijzel EL, van Beek ER, … Cruz LJ
  • CONCLUSIONS: Here we provide an overview of new promising pre-clinical developments in TBI management that may find their way to the clinic in the near future. Nanotechnology and nanomedicine in TBI intervention may establish new platforms for targeted drug delivery to the traumatized brain to improve the quality of life and survival of TBI patients.
  • MiRNAs: New Biomarkers and Therapeutic Targets in Dementia. [Journal Article]
  • CPCurr Pharm Des 2017 Jan 10
  • de Bastos Viegas AT, Guedes JR, … Cardoso AL
  • CONCLUSIONS: In this context, the major aim of this review is to discuss the relevance of these small non-coding RNAs in dementia, focusing on their role as gene expression regulators, their potential as biomarkers of dementia subtype and stage, and the hypothesis of using miRNA modulation as an innovative therapeutic approach to treat dementia-related disorders.
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