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(Developmental Medicine and Child Neurology[TA])
9,059 results
  • Cognitive outcomes in children and adolescents born very preterm: a meta-analysis. [Review]
  • DMDev Med Child Neurol 2018 Feb 17
  • Brydges CR, Landes JK, … Anderson M
  • CONCLUSIONS: Children born very preterm have medium to large deficits in these cognitive domains.This meta-analysis is centred on very preterm birth and three cognitive domains. The three critical cognitive domains are intelligence, executive functioning, and processing speed.
  • Severity of cerebral palsy and likelihood of adverse events after botulinum toxin A injections. [Journal Article]
  • DMDev Med Child Neurol 2018 Feb 16
  • Swinney CM, Bau K, … Paget SP
  • CONCLUSIONS: Adverse events after BoNT-A injections are common but mostly mild and self-limiting. Children in GMFCS levels IV and V are at increased risk of systemic adverse events. The relationship between CP severity and BoNT-A adverse events is complex and further research is required to better understand this relationship.Adverse events reported at the time of botulinum toxin A injection occurred in 6% of injection episodes. Adverse events were reported at follow-up in 22% of injection episodes. Children in Gross Motor Function Classification System (GMFCS) levels IV and V have increased rates of systemic adverse events. Children in GMFCS levels IV and V report less local weakness and pain.
  • Development and validation of the Pediatric Stroke Quality of Life Measure. [Journal Article]
  • DMDev Med Child Neurol 2018 Feb 16
  • Fiume A, Deveber G, … Friefeld S
  • CONCLUSIONS: The PSQLM demonstrates sound psychometric properties. Further research will seek to increase its clinical utility by reducing length and establishing responsiveness for descriptive and longitudinal evaluative assessment.A pediatric stroke-specific quality of life (QoL) measurement tool for assessments based on perceptions of importance and satisfaction. Moderate-to-high reliability and validity established for a new clinical scale evaluating QoL among children with stroke. Perceived QoL measured using the Pediatric Stroke Quality of Life Measure appears lower in children with neurological impairment.
  • The ketogenic diet is effective for refractory epilepsy associated with acquired structural epileptic encephalopathy. [Journal Article]
  • DMDev Med Child Neurol 2018 Feb 16
  • Villaluz MM, Lomax LB, … Scheffer IE
  • CONCLUSIONS: Somewhat surprisingly we found that the ketogenic diet was effective in patients with a developmental and epileptic encephalopathy due to an acquired structural aetiology. This cohort may not be routinely considered for the ketogenic diet because of their structural and acquired, rather than genetic, basis. The ketogenic diet should be considered early in the management of patients with acquired structural encephalopathies as it can improve seizure control with the potential to improve developmental outcome.The ketogenic diet was effective in children with epilepsy associated with an acquired structural aetiology.
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