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(Drug Alcohol Depend[TA])
7,680 results
  • Media coverage of harm reduction, 2000-2016: A content analysis of tone, topics, and interventions in Canadian print news. [Journal Article]
    Drug Alcohol Depend 2019; 205:107599Cameron Wild T, Koziel J, … Hyshka E
  • CONCLUSIONS: Although federal policy support for harm reduction waxed and waned over 17 years, Canadian newspapers independently shaped public discourse, frequently characterizing harm reduction positively/neutrally and from a health perspective. However, issue framing and agenda setting was also evident: supervised drug consumption offered in a single Canadian city crowded out coverage of all other harm reduction services, except for naloxone. This narrow sense of 'newsworthiness' obscured public discourse on the full spectrum of evidence-based harm reduction services that could benefit PWUD.
  • Association between buprenorphine/naloxone and high-dose opioid analgesic prescribing in Kentucky, 2012-2017. [Journal Article]
    Drug Alcohol Depend 2019; 205:107606Luu H, Slavova S, … Bush H
  • CONCLUSIONS: Our results indicate a significant reciprocal relationship between HDOAP and buprenorphine/naloxone prescribing and a clinically meaningful effect of buprenorphine/naloxone prescribing on reducing HDOAP. Future studies on buprenorphine/naloxone treatment expansion should take into account this bi-directional association in the context of longitudinal data and evaluate for public health benefits beyond the reduction of HDOAP.
  • Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal. [Journal Article]
    Drug Alcohol Depend 2019; 205:107596Darpö B, Pirner M, … Ferber G
  • CONCLUSIONS: Lofexidine was associated with small, transient QTcF increases. Decreases in QTcF that occurred with higher lofexidine concentrations argue for an indirect QTcF effect, potentially from changes in autonomic tone. Both opioid withdrawal and lofexidine's sympatholytic actions would be expected to alter sympathetic outflow over the 7-day withdrawal.
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