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(Drug Dev Ind Pharm[TA])
3,149 results
  • Development and characterization of a mucoadhesive sublingual formulation for pain control: extemporaneous oxycodone films in personalized therapy. [Journal Article]
  • DDDrug Dev Ind Pharm 2017 Jan 11; :1-29
  • Parodi B, Russo E, … Caviglioli G
  • CONCLUSIONS: The obtained films showed excellent drug content uniformity and stability and rapid drug release, which, at 8 min, ranged from 60 to 80%. All films presented satisfactory mucoadhesive and mechanical properties, also confirmed by a test on healthy volunteers, who did not experience irritation or mucosa damages. Pectin films based on pectin at lower degrees of esterification have been further evaluated to study the influence of two different amounts of drug on the physicochemical properties of the formulation. A slight reduction of elasticity has been observed in films containing a higher drug dose, nevertheless the formulation maintained satisfactory flexibility and resistance to elongation.HPC and PC sublingual films, obtained by a simple casting method, could be proposed to realize personalized hospital pharmacy preparations on a small scale.
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