Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Drugs R D[TA])
1,060 results
  • Effect of Sevelamer and Nicotinamide on Albumin Carbamylation in Patients with End-Stage Kidney Disease. [Journal Article]
    Drugs R D. 2021 Jun 08 [Online ahead of print]Lenglet A, Rahali MA, … Massy ZA
  • CONCLUSIONS: Our results confirmed the presence of carbamylated albumin in patients with end-stage kidney disease and demonstrated the presence of carbamylation beyond the LRVP residues. The results also demonstrated the lack of impact of sevelamer or nicotinamide on albumin carbamylation levels. Therapeutic strategies to lower carbamylation load should probably be focused on direct anti-carbamylation processes and/or potentially anti-inflammatory therapies.
  • A Review on the Efficacy and Safety of Oral Semaglutide. [Review]
    Drugs R D. 2021 Mar 26 [Online ahead of print]Niman S, Hardy J, … Choksi R
  • There are numerous treatment options currently available for patients with type 2 diabetes mellitus; however, a multitude of patients continue to have inadequately controlled glycemic levels with their current antihyperglycemic regimen. Furthermore, the American Diabetes Association guidelines increasingly highlight the importance of multifactorial management and optimizing medication regimens th…
  • Dosing Considerations for Antibodies Against COVID-19. [Review]
    Drugs R D. 2021 Mar; 21(1):1-8.Tegenge MA, Mahmood I, … Golding B
  • At present, no cure is available for COVID-19 but vaccines, antiviral drugs, immunoglobulins, or the combination of immunoglobulins with antiviral drugs have been suggested and are in clinical trials. The purpose of this paper is to discuss the role of a pharmacokinetic and viral load analysis as a basis for adjusting immunoglobulin dosing to treat COVID-19. We reviewed the pre-clinical and clini…
  • Comparability Considerations and Challenges for Expedited Development Programs for Biological Products. [Journal Article]
    Drugs R D. 2020 Dec; 20(4):301-306.Schrieber SJ, Putnam WS, … Rosado LAR
  • Expedited development programs for biological products to be used in the treatment of serious conditions bring about challenges because of the compressed clinical development timeframes. As expedited development does not lessen the quality expectations, one challenge is providing adequate chemistry, manufacturing, and control (CMC) information required to support approval of a biological product.…
  • Nimodipine Pharmacokinetic Variability in Various Patient Populations. [Journal Article]
    Drugs R D. 2020 Dec; 20(4):307-318.Mahmoud SH, Ji X, Isse FA
  • Nimodipine has been shown to improve outcomes following aneurysmal subarachnoid hemorrhage. Guidelines recommend that all patients receive a fixed dose of oral nimodipine for 21 days. However, pharmacokinetic studies have suggested variability of nimodipine pharmacokinetics in subarachnoid hemorrhage and in other patient populations. The clinical relevance of such variability is unknown. Therefor…
New Search Next