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11,061 results
  • Abnormal hippocampal functional network and related memory impairment in pilocarpine-treated rats. [Journal Article]
  • EEpilepsia 2018 Aug 02
  • Jiang Y, Han CL, … Zhang JG
  • CONCLUSIONS: Our results indicated a trend of decreased connectivity in the hippocampal functional network, as well as spatial, object, and episodic memory impairment in the pilocarpine-induced TLE rat. Moreover, connections within the hippocampal network showed a relationship with spatial memory, and connections between the hippocampal network and regions in other networks revealed an association with both spatial and object memory.
  • Perampanel in routine clinical use across Europe: Pooled, multicenter, observational data. [Journal Article]
  • EEpilepsia 2018 Jul 25
  • Rohracher A, Zimmermann G, … Trinka E
  • CONCLUSIONS: Across a large, treatment-resistant population, add-on perampanel was retained for ≥1 year by 48% of individuals, and 9% were seizure-free for ≥6 months. TEAEs were in line with previous reports in routine clinical use, and less frequent than in the clinical trial setting. No new or unexpected TEAEs were seen. Despite the limitations of observational studies, our data indicate that some individuals may derive a marked benefit from the use of perampanel.
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