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10,922 results
  • Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine. [Journal Article]
  • EEpilepsia 2018 Feb 16
  • Pazdera L, Sperling MR, … Cheng H
  • CONCLUSIONS: Baseline use of CBZ or other major putative VGSC inhibitors did not appear to significantly increase the risk of study exit due to worsening seizure control, or to increase the frequency of side effects when converting to ESL monotherapy. However, bigger improvements in efficacy may be possible in patients converting to ESL monotherapy from an AED regimen that does not include a VGSC inhibitor.
  • Increased neuronal synchrony prepares mesial temporal networks for seizures of neocortical origin. [Journal Article]
  • EEpilepsia 2018 Feb 14
  • Misra A, Long X, … Moxon KA
  • CONCLUSIONS: These results suggest a mechanism of spreading seizures whereby the seizure focus first synchronizes local field potentials in downstream networks to the seizure activity. This change in local field coherence modifies the activity of interneuron populations in these downstream networks, which leads to the attenuation of interneuronal firing rate, effectively shutting down local interneuron populations prior to the spread of seizure. Therefore, regional synchrony may influence the failure of downstream interneurons to prevent the spread of the seizures during generalization.
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