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(European journal of medical research[TA])
1,999 results
  • Neuroendocrine carcinoma of gallbladder: a case series and literature review. [Journal Article]
  • EJEur J Med Res 2019 Feb 04; 24(1):8
  • Liu W, Chen W, … He X
  • CONCLUSIONS: Gallbladder NEC showed no noticeably specific features, and the diagnosis relied on the pathological and immunohistochemistrical results. For T1N0M0 gallbladder NEC, cholecystectomy might be enough. For patients in a late stage, the management of combined therapies might be optimal.
  • Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway. [Journal Article]
  • EJEur J Med Res 2019 Jan 28; 24(1):5
  • Malsy M, Bitzinger D, … Bundscherer A
  • CONCLUSIONS: Modern therapeutic strategies for tumor diseases target the efficient modulation of specific signaling and transcription pathways. In this respect, the therapeutic potential of protein kinase inhibitors has been repeatedly discussed. Our study showed that staurosporine induces apoptosis in pancreatic carcinoma cells via the intrinsic signaling pathway. Thus, staurosporine is a suitable positive control for in vitro apoptosis tests for the pancreatic cancer cell lines PaTu 8988t and Panc-1. Further clinical studies should analyze the impact of this finding on cancer treatment.
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