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31,628 results
  • Optogenetic Induction of Colonic Motility in Mice. [Journal Article]
  • GGastroenterology 2018 May 18
  • Hibberd TJ, Feng J, … Spencer NJ
  • CONCLUSIONS: In studies of mice, we found that focal activation of a subset of enteric neurons can increase motility of the entire colon in vitro, and fecal output in vivo. Optogenetic control of enteric neurons might therefore be used to modify gut motility.
  • Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. [Journal Article]
  • GGastroenterology 2018 May 18
  • VanDussen KL, Stojmirović A, … Stappenbeck TS
  • CONCLUSIONS: In a transcriptome analysis of formalin-fixed, paraffin-embedded ileal tissues from patients with CD and controls, we associated transcriptional alterations with histologic alterations, such as differences in microvilli length. Decreased microvilli length and reduced expression of the microvilli gene set might contribute to epithelial malfunction and the chronic, progressive disease course in patients with CD.
  • Mitotic and apoptotic activity in colorectal neoplasia. [Journal Article]
  • BGBMC Gastroenterol 2018 May 18; 18(1):65
  • Kohoutova D, Pejchal J, Bures J
  • CONCLUSIONS: Significant dysregulation of mitosis and apoptosis during the progression of colorectal neoplasia, corresponding with histology, was confirmed. In patients with sporadic colorectal neoplasia, healthy mucosa does not display different mitotic and apoptotic activity compared to mucosa in healthy controls and therefore adequate endoscopic/surgical removal of colorectal neoplasia is sufficient.
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