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16,909 results
  • Fine needle aspirates comprehensively sample intrahepatic immunity. [Journal Article]
  • GutGut 2018 Nov 28
  • Gill US, Pallett LJ, … Maini MK
  • CONCLUSIONS: We demonstrate for the first time that FNAs identify a range of intrahepatic immune cells including locally resident sentinel HBV-specific T cells and NK cells, together with PD-L1-expressing hepatocytes. In addition, we provide a scoring tool to estimate the extent to which an individual FNA has reliably sampled intrahepatic populations rather than contaminating blood. The broad profiling achieved by this less invasive, rapid technique makes it suitable for longitudinal monitoring of the liver to optimise new therapies for HBV.
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