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Unbound Medicine.
(Hum Psychopharmacol[TA])
1,436 results
  • Inverse correlation between plasma 2-arachidonoylglycerol levels and subjective severity of depression. [Journal Article]
    Hum Psychopharmacol. 2021 Feb 09 [Online ahead of print]Bersani G, Pacitti F, … Nasca C
  • CONCLUSIONS: Our results suggest that 2-arachidonylglycerol, the most abundant endocannabinoid in the central nervous system, might act to mitigate depressive symptoms, and raise the interesting possibility that 2-arachidonylglycerol and anandamide are differentially regulated in patients affected by MDD. Also, our data suggest but do not prove that the endocannabinoid system is not regulated by serotonergic transmission, at least in depressed patients.
  • An explorative approach to understanding individual differences in driving performance and neurocognition in long-term benzodiazepine users. [Journal Article]
    Hum Psychopharmacol. 2021 Feb 06 [Online ahead of print]Vinckenbosch FRJ, Vermeeren A, … Ramaekers JG
  • CONCLUSIONS: Functional impairments in long-term BZRA users are not attributable to self-reported clinical complaints or estimated BZRA concentrations, except for road-tracking, which was impaired in CBZRA + users. Limitations to address are the lack of assessment of objective clinical complaints, acute task related stress, and actual BZRA plasma concentrations. In conclusion, the results confirm previous findings that demonstrate inferior performance across several psychomotor and neurocognitive domains in long-term BZRA users.
  • A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia. [Journal Article]
    Hum Psychopharmacol. 2020 Dec 26 [Online ahead of print]Segura IA, McGhee J, … Pompéia S
  • CONCLUSIONS: Diazepam's amnestic effects mirror those in patients with probable severe medial temporal damage, mostly restricted to initial consolidation and differ from other OAA (Korsakoff syndrome, frontal, transient epileptic, posttraumatic amnesia, and most progressive amnesias) in terms of WMC, susceptibility to RI and accelerated forgetting.
  • Could N-acetylcysteine improve the safety of clozapine? [Journal Article]
    Hum Psychopharmacol. 2020 Nov 18 [Online ahead of print]Chrétien B, Fedrizzi S, … Dolladille C
  • Clozapine is an atypical antipsychotic indicated in patients with treatment-resistant schizophrenia which remains underused due to safety issues. Mechanisms behind these adverse effects are complex and not fully understood. They may involve immune-related mechanisms, direct toxic effects and oxidative stress. Clozapine-induced oxidative stress might indeed notably be involved in the onset of neut…
  • Blinding and bias in a hypnotic clinical trial. [Journal Article]
    Hum Psychopharmacol. 2021 Jan; 36(1):1-5.McCall WV, Benca RM, … Krystal AD
  • CONCLUSIONS: "Best guesses" of all parties were not different from chance, suggesting that the blind was maintained and that assessment bias was minimized in this RCT of zolpidem ER versus placebo. Our results may not apply to other hypnotics or other RCT designs.
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