- Effect of crocin versus fluoxetine in treatment of mild to moderate obsessive-compulsive disorder: A double blind randomized clinical trial. [Journal Article]Hum Psychopharmacol. 2021 Feb 18 [Online ahead of print]HP
- CONCLUSIONS: According to our study, it seems that crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.
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- Inverse correlation between plasma 2-arachidonoylglycerol levels and subjective severity of depression. [Journal Article]Hum Psychopharmacol. 2021 Feb 09 [Online ahead of print]HP
- CONCLUSIONS: Our results suggest that 2-arachidonylglycerol, the most abundant endocannabinoid in the central nervous system, might act to mitigate depressive symptoms, and raise the interesting possibility that 2-arachidonylglycerol and anandamide are differentially regulated in patients affected by MDD. Also, our data suggest but do not prove that the endocannabinoid system is not regulated by serotonergic transmission, at least in depressed patients.
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- An explorative approach to understanding individual differences in driving performance and neurocognition in long-term benzodiazepine users. [Journal Article]Hum Psychopharmacol. 2021 Feb 06 [Online ahead of print]HP
- CONCLUSIONS: Functional impairments in long-term BZRA users are not attributable to self-reported clinical complaints or estimated BZRA concentrations, except for road-tracking, which was impaired in CBZRA + users. Limitations to address are the lack of assessment of objective clinical complaints, acute task related stress, and actual BZRA plasma concentrations. In conclusion, the results confirm previous findings that demonstrate inferior performance across several psychomotor and neurocognitive domains in long-term BZRA users.
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- Effect of necessity-concern framework and polypharmacy on treatment adherence in psychiatric patients. Comparing an Argentinian with a Spanish sample. [Journal Article]Hum Psychopharmacol. 2021 Jan 28 [Online ahead of print]HP
- CONCLUSIONS: The Argentinian sample replicated the previous finding that patient beliefs regarding necessity and concern were associated with poor adherence to prescribed medications. Polypharmacy had an additive role decreasing adherence in both samples. In both samples, when prescribed ≥4 psychiatric medications, patients reported adherence to only two-third of the medications.
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- Safety of switching to brexpiprazole in Japanese patients with schizophrenia: A post-hoc analysis of a long-term open-label study. [Journal Article]Hum Psychopharmacol. 2021 Jan 26 [Online ahead of print]HP
- CONCLUSIONS: Switching to brexpiprazole is associated with a low long-term risk for metabolic abnormalities (including weight gain), hyperprolactinemia, extrapyramidal symptoms and QTc changes and minimal changes in psychiatric symptoms.
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- Acute caffeine intake in humans reduces post exercise performance in learning and memory. [Journal Article]Hum Psychopharmacol. 2021 Jan 25 [Online ahead of print]HP
- CONCLUSIONS: The consumption of caffeine prior to exercise may impair an unhabituated individual's capacity to learn and recall auditory information postexercise. However it is yet to be elucidated whether this is through caffeine's modulating effects on brain BDNF.
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- A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia. [Journal Article]Hum Psychopharmacol. 2020 Dec 26 [Online ahead of print]HP
- CONCLUSIONS: Diazepam's amnestic effects mirror those in patients with probable severe medial temporal damage, mostly restricted to initial consolidation and differ from other OAA (Korsakoff syndrome, frontal, transient epileptic, posttraumatic amnesia, and most progressive amnesias) in terms of WMC, susceptibility to RI and accelerated forgetting.
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- Is short-term antidepressant treatment effective and safe in bipolar depression? Results from an observational multicenter study. [Journal Article]Hum Psychopharmacol. 2020 Dec 22 [Online ahead of print]HP
- CONCLUSIONS: Acute AD treatment of bipolar depression is effective in the short-term and safe in the short- and long-term, when administered in combination with MSs and/or second-generation antipsychotics, with a low risk of switch, mixed depression and cycle acceleration.
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- Consistency of hangover experiences after a night of drinking: A controlled laboratory study. [Journal Article]Hum Psychopharmacol. 2020 Dec 01 [Online ahead of print]HP
- CONCLUSIONS: A single 'Hangover' rating was a reliable way of determining 'mild' to 'moderate' hangover severity. The present data could be used to assist the methodological design of future hangover research.
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- Correlation between pharmacokinetics and pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Selective Serotonin and Noradrenaline Reuptake Inhibitors and maternal and neonatal outcomes: Results from a naturalistic study in patients with affective disorders. [Journal Article]Hum Psychopharmacol. 2020 Nov 30 [Online ahead of print]HP
- CONCLUSIONS: Plasma levels of Sertraline, Citalopram and Escitalopram were more frequently in range in late pregnancy when compared to other drugs. Drug plasma concentrations do not strictly correlate with worse perinatal outcomes, but with possible differences between the different drugs.
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- Serum levels of neuropeptide Y in patients with chronic schizophrenia during treatment augmentation with sarcosine (results of the double-blind randomized controlled PULSAR study). [Journal Article]Hum Psychopharmacol. 2020 Nov 27 [Online ahead of print]HP
- CONCLUSIONS: The use of sarcosine does not change NPY levels. Peripheral NPY concentrations may be related to depressive symptoms in schizophrenia.
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- Effects of Korean red ginseng on human gray matter volume and cognitive function: A voxel-based morphometry study. [Journal Article]Hum Psychopharmacol. 2020 Nov 20 [Online ahead of print]HP
- CONCLUSIONS: Gray matter volume increase in the parahippocampus may be a key neural change as induced by KRG supplementation, which could be associated with cognitive enhancement.
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- Could N-acetylcysteine improve the safety of clozapine? [Journal Article]Hum Psychopharmacol. 2020 Nov 18 [Online ahead of print]HP
- Clozapine is an atypical antipsychotic indicated in patients with treatment-resistant schizophrenia which remains underused due to safety issues. Mechanisms behind these adverse effects are complex and not fully understood. They may involve immune-related mechanisms, direct toxic effects and oxidative stress. Clozapine-induced oxidative stress might indeed notably be involved in the onset of neut…
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- In vivo gamma-aminobutyric acid -A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study. [Journal Article]Hum Psychopharmacol. 2020 Nov 13 [Online ahead of print]HP
- CONCLUSIONS: This study, for the first time, reports correlations between the genetic liability of schizophrenia and GABAR availability. Correlations between [11C]flumazenil binding in caudate of individuals with high genetic liability to schizophrenia suggests that the GABAergic dysfunction may arise from shared genetic factors and also that it may be responsible for cognitive impairment of AIs.
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- Estimated model of psychotropic polypharmacy for bipolar disorder: Analysis using patients' and practitioners' parameters in the MUSUBI study. [Journal Article]Hum Psychopharmacol. 2020 Oct 22 [Online ahead of print]HP
- CONCLUSIONS: Our findings indicated that patient-related conditions affected psychotropic polypharmacy more strongly than did practitioner-related conditions.
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- Effects of aripiprazole long-acting injectable antipsychotic on hospitalization in recent-onset schizophrenia. [Journal Article]Hum Psychopharmacol. 2020 Oct 15 [Online ahead of print]HP
- CONCLUSIONS: Results suggest that ALAI is an important therapeutic option in patients with ROS. It leads to reduced usage of hospital services, potentially reducing the socio-economic healthcare burden.
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- Driving performance and neurocognitive skills of long-term users of sedating antidepressants. [Journal Article]
- CONCLUSIONS: The impairing effects of antidepressant treatment on driving performance and neurocognition mitigate over time following long-term use of 3 years.
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- Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial. [Journal Article]Hum Psychopharmacol. 2021 Jan; 36(1):1-12.HP
- CONCLUSIONS: OLA induced more cardiovascular changes; however, more ADRs were registered to ARI. In addition, some polymorphisms may explain the difference in the incidence of these effects among subjects.
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- The safety of agomelatine in standard medical practice in depressed patients: A 26-week international multicentre cohort study. [Journal Article]
- CONCLUSIONS: In standard medical practice, agomelatine treatment was associated with a low incidence of side effects. No unexpected events were reported. A decrease in the severity of the depressive episode and improved functioning were observed.
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- Relationship between suicide rate and antidepressant prescription: An ecological study in the People's Republic of China. [Journal Article]Hum Psychopharmacol. 2021 Jan; 36(1):1-9.HP
- CONCLUSIONS: Suicide varied among different studied stratum. Suicide rates are negatively associated with antidepressant prescriptions.
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- Alpha7 nicotinic-N-methyl-D-aspartate hypothesis in the treatment of schizophrenia and beyond. [Journal Article]
- Development of novel treatments for positive, cognitive, and negative symptoms continue to be a high-priority area of schizophrenia research and a major unmet clinical need. Given that all randomized controlled trials (RCTs) conducted to date failed with one add-on medication/mechanism of action, future RCTs with the same approach are not warranted. Even if the field develops a medication for cog…
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- Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia. [Journal Article]Hum Psychopharmacol. 2020 11; 35(6):1-8.HP
- CONCLUSIONS: Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone.
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- Blinding and bias in a hypnotic clinical trial. [Journal Article]Hum Psychopharmacol. 2021 Jan; 36(1):1-5.HP
- CONCLUSIONS: "Best guesses" of all parties were not different from chance, suggesting that the blind was maintained and that assessment bias was minimized in this RCT of zolpidem ER versus placebo. Our results may not apply to other hypnotics or other RCT designs.
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- Effects of Panax quinquefolius (American ginseng) on the steady state visually evoked potential during cognitive performance. [Journal Article]
- CONCLUSIONS: These findings provide preliminary evidence of increased recruitment of prefrontal brain regions during working memory processing following a single acute dose of P. quinquefolius.
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- Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia. [Journal Article]Hum Psychopharmacol. 2020 11; 35(6):1-8.HP
- CONCLUSIONS: DβH 5'-Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia.
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- Methylphenidate challenge test in adults with attention deficit/hyperactivity disorder (ADHD): Clinical effects and their predictors. [Journal Article]Hum Psychopharmacol. 2020 09; 35(5):e2740.HP
- CONCLUSIONS: These findings point to the efficacy of MPH challenge in improving concentration and tension in adult ADHD, thus emphasizing the need for a broader treatment access for these patients.
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- Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers. [Journal Article]Hum Psychopharmacol. 2020 11; 35(6):1-7.HP
- CONCLUSIONS: We provide the first tentative behavioral evidence to support the anxiolytic properties of Sceletium tortuosum (25 mg Zembrin®).
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- Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study. [Journal Article]Hum Psychopharmacol. 2020 11; 35(6):1-7.HP
- CONCLUSIONS: Schizophrenia patients receiving adjunctive MS treatment in Asian psychiatric centers are more severely ill and less responsive to simpler treatment regimens.
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- The effect of cannabidiol on simulated car driving performance: A randomised, double-blind, placebo-controlled, crossover, dose-ranging clinical trial protocol. [Journal Article]Hum Psychopharmacol. 2020 09; 35(5):e2749.HP
- CONCLUSIONS: This study will clarify the risks involved in driving following CBD use and assist in ensuring the safe use of CBD by drivers.
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- Gabapentinoids for treatment of alcohol use disorder: A systematic review and meta-analysis. [Journal Article]Hum Psychopharmacol. 2020 11; 35(6):1-11.HP
- CONCLUSIONS: GBP may be helpful to reduce AUD patients' heavy drinking behavior and withdrawal, but more studies are needed for drawing conclusions.
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