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Unbound Medicine.
(J Anal Toxicol[TA])
4,022 results
  • The Effect of Prolonged Storage Time on the Stability of Fatty Acid Ethyl Esters in Hair Samples. [Journal Article]
    J Anal Toxicol. 2020 Mar 18 [Online ahead of print]Tsanaclis L, Bagley K, … Wicks J
  • The advantages of analysis of drugs in hair samples are recognised for the long window of detection, alongside easy sampling and long stability after sample collection. Alcohol markers, ethyl glucuronide (EtG) and total fatty acid ethyl esters (FAEEs) in hair are widely used for monitoring alcohol consumption for clinical and forensic purposes. Although stability of drugs and EtG in hair samples …
  • Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry. [Journal Article]
    J Anal Toxicol. 2020 Feb 25 [Online ahead of print]Rubin KM, Goldberger BA, Garrett TJ
  • A recently proposed model for the incorporation of xenobiotics of forensic interest into the human skeleton suggests nerve agent metabolites may incorporate into bone at relatively elevated concentrations based on their unique chemical properties. To test the hypothesis that nerve agent metabolites interact with bone, methods for the extraction, isolation and semi-quantitative detection of nerve …
  • Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework. [Journal Article]
    J Anal Toxicol. 2020 Feb 24 [Online ahead of print]Krotulski AJ, Papsun DM, … Logan BK
  • The synthetic opioid landscape continues to change as non-fentanyl related substances appear in forensic toxicology casework. Among the newest synthetic opioids to emerge is isotonitazene, an analogue of a benzimidazole class of analgesic compounds. Isotonitazene is an active and potent synthetic opioid, but the extent to which this compound is causing toxicity among drug users was previously unk…
  • Quantification of Furanyl Fentanyl and its Metabolites in Human and Rat Plasma using LC-MS/MS. [Journal Article]
    J Anal Toxicol. 2020 Feb 12 [Online ahead of print]Palmquist KB, Swortwood M
  • Fentanyl analogs (novel and traditional) continue to impact the ever-growing opioid epidemic. Furanyl fentanyl is one analog equipotent to fentanyl that has documented involvement in thousands of intoxication and fatality cases around the world. Due to its prevalence, toxicologists need to improve detection and understanding of this analog. A method for the quantification of furanyl fentanyl (FuF…
  • LC-MS/MS METHOD FOR THE DETERMINATION OF ANTIDEPRESSANTS AND BENZODIAZEPINES IN MECONIUM. [Journal Article]
    J Anal Toxicol. 2020 Feb 12 [Online ahead of print]López-Rabuñal A, Lendoiro E, … de-Castro-Ríos A
  • An LC-MS/MS method for the determination of 14 benzodiazepines (alprazolam, α-hydroxyalprazolam, clonazepam, bromazepam, diazepam, nordiazepam, lorazepam, lormetazepam, oxazepam, flunitrazepam, 7-aminoflunitrazepam, triazolam, midazolam and zolpidem) and 15 antidepressants (amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, norclomipramine, fluoxetine, norfluoxetine, sertraline,…
  • Toxicological and Demographic Profiles of Phencyclidine-Impaired Driving Cases in Houston. [Journal Article]
    J Anal Toxicol. 2020 Feb 03 [Online ahead of print]Lee D, Stout P
  • Phencyclidine (PCP) was first synthesized in 1926 and originally developed in 1950s as a general anesthetic agent. Abuse of PCP declined at the national level since its first illicit use in 1960s, but it continues in certain areas including Houston. This research evaluates PCP-positive cases of driving while intoxicated (DWI) in 2013-2018. The blood samples were collected from drivers, submitted …
  • Stability and Degradation Pathways of Different Psychoactive Drugs in Neat and in Buffered Oral Fluid. [Journal Article]
    J Anal Toxicol. 2020 Feb 05 [Online ahead of print]Marchei E, Malaca S, … Busardò FP
  • Sampling and drug stability in oral fluid (OF) are crucial factors when interpreting forensic toxicological analysis, mainly because samples may not be analyzed immediately after collection, potentially altering drug concentrations. Therefore, the stability of some common drugs of abuse (morphine, codeine, 6-monoacetylmorphine, cocaine, benzoylecgonine, Δ9-tetrahydrocannabinol, cannabidiol, amphe…
  • Carfentanil Use in a Patient Undergoing Treatment for Substance Use Disorder. [Journal Article]
    J Anal Toxicol. 2020 Feb 04 [Online ahead of print]Tuzel T, Banks JF, Hobbs GA
  • Carfentanil is a synthetic opioid approximately 10,000 times as powerful as morphine. It is not approved for human use. However, cases of death associated with carfentanil have become more frequent in recent years. In this report, the case of a patient with a positive urine test for norcarfentanil (a metabolite of carfentanil) is described. The analytical method leading to the detection is summar…
  • A retrospective of prevalence of drugs of abuse by hair analysis in Shanghai using LC-MS/MS. [Journal Article]
    J Anal Toxicol. 2020 Feb 04 [Online ahead of print]Wang X, Cui J, … Xiang P
  • This study presents a retrospective analysis of the prevalence of drug abuse in Shanghai by hair analysis. Files and toxicology analysis results of a total of 5,610 cases requesting for hair analysis of abused drugs at the Academy of Forensic Science (AFS) in Shanghai over 12 months between August 2018 and July 2019 were reviewed. All cases of drug abuse identified by hair analysis were from the …
  • Method Consolidation to Improve Scope and Efficiency in Postmortem Toxicology. [Journal Article]
    J Anal Toxicol. 2020 Feb 04 [Online ahead of print]Gevorkyan J, Wong M, … Rodda LN
  • Systematic toxicological approaches that employ both ideology changes and improvements in instrumentation and sample extraction allow for improved toxicology testing efficiency through lower sensitivities, higher specificity and minimized resource use. Historically, the San Francisco Office of the Chief Medical Examiner relied heavily on a GC-MS testing regime, comprised of individual drug-class …
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