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(J Clin Pathol[TA])
15,565 results
  • Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. [Journal Article]
  • JCJ Clin Pathol 2017 Apr 20
  • Nguyen Canh H, Harada K, … Intractable Liver and Biliary Diseases Study Group of Japan
  • CONCLUSIONS: The acute presentation of AIH represents the entire histological spectrum of acute hepatitis and chronic hepatitis with various activity grades and fibrosis stages that clinically correspond to acute-onset AIH and acute exacerbation of classic AIH, respectively. Although there are no pathognomonic features for the pathological diagnosis, the prominent presence of lobular and perivenular necroinflammatory activity, pigmented macrophages and cobblestone appearance of hepatocytes in addition to the classic AIH features, such as plasma cell infiltration and emperipolesis, are useful for the pathological diagnosis of the acute presentation of AIH.
  • BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods. [Journal Article]
  • JCJ Clin Pathol 2017 Apr 19
  • O'Brien O, Lyons T, … Heffron CCBB
  • CONCLUSIONS: The rate of BRAF mutation in our cohort (28.8%) was lower than international published rates of 40%-60%. This may reflect ethnic or geographic differences within population cohorts. The high concordance rate of PCR and immunohistochemical methods in determining BRAF status suggests that immunohistochemistry is potentially a viable, cost-effective alternative to PCR testing and suitable as a screening test for the BRAF mutation.
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