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(J Psychopharmacol[TA])
3,349 results
  • Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. [Journal Article]
  • JPJ Psychopharmacol 2019 Jul 14; :269881119857204
  • Kuypers KP, Ng L, … Nutt D
  • CONCLUSIONS: It is concluded that while most anecdotal reports focus on the positive experiences with microdosing, future research should also focus on potential risks of (multiple) administrations of a psychedelic in low doses. To that end, (pre)clinical studies including biological (e.g. heart rate, receptor turnover and occupancy) as well as cognitive (e.g. memory, attention) parameters have to be conducted and will shed light on the potential negative consequences microdosing could have.
  • Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates. [Journal Article]
  • JPJ Psychopharmacol 2019 Jul 11; :269881119856850
  • Cunningham JI, Eyerman DJ, … Namchuk M
  • CONCLUSIONS: Olanzapine administration increased weight gain and adiposity, both of which were attenuated by samidorphan. Furthermore, the combination of olanzapine and samidorphan prevented olanzapine-induced insulin insensitivity. Collectively, these data indicate that samidorphan mitigates several metabolic abnormalities associated with olanzapine in both the presence and the absence of weight gain.
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