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(Journal of Allergy and Clinical Immunology[TA])
17,573 results
  • Basophil Activation Test Differentiates Between Patients with Alpha-Gal Syndrome and Asymptomatic Alpha-Gal Sensitization. [Journal Article]
  • JAJ Allergy Clin Immunol 2018 Aug 17
  • Mehlich J, Fischer J, … Eberlein B
  • CONCLUSIONS: The basophil activation test should be considered as an additional diagnostic test before performing time-consuming and potentially risky oral provocation tests. The ratio %CD63+/anti-FcεRI for all allergens and AUC for pork kidney were the best parameters for distinguishing patients with alpha-gal syndrome from individuals with asymptomatic alpha-gal sensitization.Distinct parameters of the basophil activation test allowed a good differentiation between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization and should be determined before performing oral provocation tests.
  • Baseline IL22 expression in atopic dermatitis patients stratifies tissue responses to fezakinumab. [Journal Article]
  • JAJ Allergy Clin Immunol 2018 Aug 16
  • Brunner PM, Pavel AB, … Guttman-Yassky E
  • CONCLUSIONS: This is the first report showing a profound effect of IL-22 blockade on multiple inflammatory pathways in AD. These data, supported by the robust effects in patients with high IL22 baseline expression, suggest a central role for IL-22 in AD, indicating the need for a precision medicine approach for improving therapeutic outcomes in AD.Stratification of cytokine expression at baseline might help future precision medicine approaches to effectively treat atopic dermatitis patient subsets that might benefit from IL-22 antagonism or other specific blockers.
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