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(Journal of Clinical Endocrinology and Metabolism[TA])
33,475 results
  • The short cosyntropintest revisited - new normal reference range using LCMSMS. [Journal Article]
  • JCJ Clin Endocrinol Metab 2018 Feb 14
  • Ueland GÅ, Methlie P, … Husebye ES
  • CONCLUSIONS: Using LCMSMS, cutoff levels for cortisol and 17-OHP after cosyntropin stimulation are lower than those based on immunoassays, possibly since cross-reactivity between steroid intermediates and cortisol is eliminated. This reduces the number of false positive tests for AI and false negative test for NCCAH.
  • Mitotane monotherapy in patients with advanced adrenocortical carcinoma. [Journal Article]
  • JCJ Clin Endocrinol Metab 2018 Feb 14
  • Megerle F, Herrmann W, … German ACC Study Group
  • CONCLUSIONS: With 20.5% the objective response rate was slightly lower than previously reported. However, more than 20% of patients experienced a long-term disease control >1 year. In general, patients with late diagnosis of advanced disease and low tumor burden might especially benefit from mitotane monotherapy, whereas patients with early advanced disease and high tumor burden are probably better candidates for combined therapy of mitotane and cytotoxic drugs.
  • Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs. Adolescent Puberty: Human Genetic Evidence. [Journal Article]
  • JCJ Clin Endocrinol Metab 2018 Feb 14
  • Shahab M, Lippincott M, … Seminara S
  • CONCLUSIONS: This is the first association of biallelic loss-of-function mutations in KISS1R with normal timing of adolescent puberty. Moreover, because these coding sequence variants occurred in a subject with microphallus and cryptorchidism, they demonstrate different levels of dependence of the hypothalamic-pituitary-gonadal cascade on kisspeptin signaling at distinct times in the reproductive life span. The suppression of the hypothalamic-pituitary-gonadal cascade during early life but not adolescence suggests that the mini puberty of infancy is more dependent upon kisspeptin-induced, GnRH-induced LH secretion than adolescent puberty.
  • Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations. [Journal Article]
  • JCJ Clin Endocrinol Metab 2018 Feb 08
  • Klein KO, Rosenfield R, … Mauras N
  • CONCLUSIONS: Evidence supports the effectiveness of starting pubertal estrogen replacement with low-dose transdermal estradiol (E2). When transdermal E2 is not available or the patient prefers, evidence supports use of an oral micronized E2 or intramuscular preparation. Only when these are unavailable, should ethinyl estradiol be prescribed. We recommend against the use of conjugated estrogens. Once progestin is added many women prefer the ease of use of a pill containing both an estrogen and progestin. The risks and benefits of different types of preparations, with examples, are discussed.
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