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(Journal of Clinical Pathology[TA])
16,078 results
  • Distribution of mast cell subtypes in interstitial cystitis: implications for novel diagnostic and therapeutic strategies? [Journal Article]
  • JCJ Clin Pathol 2018 May 15
  • Malik ST, Birch BR, … Lwaleed BA
  • CONCLUSIONS: Our results suggest that mastocytosis is present within all layers of disease bladder, especially the muscle layer. The varying increase in MC subtypes in the lamina and mucosa may explain the variability in painful bladder syndrome/interstitial cystitis symptoms. A high influx of MCTC in the mucosa of individuals who also had ulceration noted within their diagnostic notes may be of the Hunner's ulcer subclassification. These findings suggest a relationship between the pathogenesis of MC subtypes and the clinical presentation of painful bladder syndrome/interstitial cystitis. A cohort study would further elucidate the diagnostic and/or therapeutic potential of MCs in patients with painful bladder syndrome/interstitial cystitis.
  • Contemporary prostate biopsy reporting: insights from a survey of clinicians' use of pathology data. [Journal Article]
  • JCJ Clin Pathol 2018 May 02
  • Varma M, Narahari K, … Berney DM
  • CONCLUSIONS: The number of positive cores is an important parameter for patient management but may be difficult to determine in the laboratory due to core fragmentation so the biopsy taker must indicate the number of biopsies obtained. Multiple biopsies taken from a single site are often interpreted by clinicians as separate cores when determining the number of positive cores so pathologists should also report the number of sites positive. Clinicians have a non-uniform approach to the interpretation of multiple GS in prostate biopsy reports so we recommend that pathologists also include a single 'bottom-line' GS for each case to direct the clinician's treatment decision.
  • Smad4/DPC4. [Review]
  • JCJ Clin Pathol 2018 May 02
  • McCarthy AJ, Chetty R
  • Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor be...
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