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(Journal of Clinical Psychiatry[TA])
10,471 results
  • Differences in Duloxetine Dosing Strategies in Smoking and Nonsmoking Patients: Therapeutic Drug Monitoring Uncovers the Impact on Drug Metabolism. [Journal Article]
  • JCJ Clin Psychiatry 2018 Sep 04; 79(5)
  • Augustin M, Schoretsanitis G, … Paulzen M
  • CONCLUSIONS: Despite higher daily doses, smokers had considerably lower serum duloxetine concentrations. The induction of CYP1A2 by tobacco smoke is a clinically relevant factor for drugs that are substrates for CYP1A2. Clinicians should actively assess smoking status, inform patients about the effect of smoking on duloxetine metabolism, and anticipate higher serum concentrations in the case of smoking cessation. Therapeutic drug monitoring ensures treatment efficacy by enabling the personalizing of treatment, as smokers need higher duloxetine doses to target serum concentrations within the therapeutic reference range.
  • Suicidality 6 Years After Occupational Injury. [Journal Article]
  • JCJ Clin Psychiatry 2018 Sep 04; 79(5)
  • Chin WS, Guo YL, … Shiao JSC
  • CONCLUSIONS: The suicidality rate increased at 6 years after occupational injury. The relevant factors for suicidal ideation were injury severity and work instability. Periodic monitoring of psychological and physical health and economic stability are warranted.
  • Cost-Effectiveness of Behavioral Activation for Depression in Older Adult Veterans: In-Person Care Versus Telehealth. [Journal Article]
  • JCJ Clin Psychiatry 2018 Aug 28; 79(5)
  • Egede LE, Dismuke CE, … Frueh BC
  • CONCLUSIONS: Although the intervention costs for telehealth were higher relative to in-person care, veterans receiving behavioral activation via telehealth had lower health utilization costs 1 year after the intervention than those receiving care in person while QALYs were approximately the same. These results demonstrate the noninferiority of telehealth in treating depression in veterans with respect to QALYs and a large and significant cost benefit of using telehealth in terms of health services utilization post-intervention.
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