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(Journal of the National Cancer Institute[TA])
22,481 results
  • ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer. [Journal Article]
  • JNCIJ Natl Cancer Inst 2017 Dec 01; 109(12)
  • Pietrantonio F, Di Nicolantonio F, … Cremolini C
  • CONCLUSIONS: ALK, ROS1, and NTRK rearrangements define a new rare subtype of mCRC with extremely poor prognosis. Primary tumor site, MSI-high, and RAS and BRAF wild-type status may help to identify patients bearing these alterations. While sensitivity to available treatments is limited, targeted strategies inhibiting ALK, ROS, and TrkA-B-C provided encouraging results.
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