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Unbound Medicine.
(Nat Prod Commun[TA])
3,548 results
  • Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4. [Journal Article]
    Nat Prod Commun. 2019 May; 14(5):1934578X19849202.Staup AJ, De Silva IU, … Johnson MA
  • Coronaviruses (CoVs) that cause infections such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome phylogenetically originate from bat CoVs. The coronaviral nonstructural protein 3 (nsp3) has been implicated in viral replication, polyprotein cleavage, and host immune interference. We report the structure of the C domain from the SARS-Unique Domain of bat CoV HKU4. Th…
  • Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening. [Journal Article]
    Nat Prod Commun. 2019 Jan; 14(1):71-74.Roy A, McDonald P, … Chaguturu R
  • We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Eleme…
  • BaMORC: A Software Package for Accurate and Robust 13C Reference Correction of Protein NMR Spectra. [Journal Article]
    Nat Prod Commun. 2019 May; 14(5)Chen X, Smelter A, Moseley HNB
  • We describe BaMORC, a software package that performs 13C chemical shifts reference correction for either assigned or unassigned peak lists derived from protein NMR spectra. BaMORC provides an intuitive command line interface that allows non-NMR experts to detect and correct 13C chemical shift referencing errors of unassigned peak lists at the very beginning of NMR data analysis, further lowering …
  • Phytochemicals and Biological Activities of Laurel Tree (Laurus nobilis). [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):743-757.Alejo-Armijo A, Altarejos J, Salido S
  • This review summarizes the chemical composition reported up to date on Laurus nobilis L. (Lauraceae), an evergreen shrub or tree cultivated for its aromatic leaves and ornamental interest. It has been focused on non-volatile phytochemicals such as sesquiterpene lactones, flavonoids and proanthocyanidins, among others. Moreover, biological activities of laurel extracts and pure compounds have also…
  • Occurrence and Chemical Synthesis of Apocarotenoids from Mucorales: A Review. [Review]
    Nat Prod Commun. 2017 May; 12(5):733-741.Barrero AF, Herrador Del Pino MM, … González-Delgado JA
  • Apocarotenoids are metabolites originated by degradation of carotenes through the loss of carbon atoms placed at the side chain of their structure as consequence of oxydative reactions. We present here the first review of apocarotenoids in the fungi mucorales Phycomyces blakesleeanus, Blakeslea trispora and Mucor mucedo. This review is divided into two parts: the first one presents their structur…
  • Nematicidal Activity of the Essential Oil of Three Varieties of Tagetes minuta from Argentina. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):705-707.Massuh Y, Cruz-Estrada A, … Andrés MF
  • Essential oils composition of three Tagetes minuta varieties and a wild population (WP) from Argentina and their in vitro and in vivo nematicidal activity against root-knot nematode, Meloidogynejavanica, are described. All T. minuta EOs tested were very active against nematode juveniles (J2), but the strongest nematicidal effects were exhibited by the TmV3 variety oil, characterized by a high con…
  • The Dimerization of Precocene I. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):691-694.Fraga BM, Cabrera I
  • In an earlier work we reported that treatment of precocene I with Brönsted and Lewis acids produces its oligomerization, giving dimers, trimers, tetramers, etc. Now, in this article we show that bromination of precocene I with phenyltrimethylammonium tribromide (PTT) blocks its oligomerization giving a dibromo- dimer, which was reduced with tri-n-butyl tin hydride affording the same dimer obtaine…
  • Profiling of Phenolic Natural Products in the Seagrass Zostera noltei by UPLC-MS. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):687-690.Manck L, Quintana E, … Zubia E
  • Seagrasses are marine plants that play important ecological functions in coastal ecosystems. The species Zostera noltei is widely distributed along the European coasts thriving in a variety of environmental conditions. In this study, the phenolic natural products of Z. noltei have been analyzed quantitatively by using UPLC-MS. Plants from the Natural Park of the Bay of Cadiz (Spain) were shown to…
  • New Fluvirucinins C1 and C2 Produced by a Marine Derived Actinomycete. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):679-682.Costa M, Zúñiga P, … Cuevas C
  • Two new fluvirucin aglycones, named fluvirucinins C, and C2 (1-2), have been isolated from the ethyl acetate mycelial cake extract of the fermentation broth of.a marine sponge-associated actinomycete. Fluvirucinins C, (1) and C2 (2) represent a new type of 14-membered macrolactam aglycon, structurally related with the common aglycon of the known fluvirucins. Their structures were elucidated on th…
  • Pentacyclic Triterpenoids from Maytenus cuzcoina. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):675-678.Reyes CP, Jiménez IA, Bazzocchi IL
  • Phytochemical analysis of the root bark extract of Maytenus cuzcoina (Celastraceae) led to the isolation and characterization of sixteen triterpenoids with a 6/6/6/6/6 pentacyclic system, including the new 22α-hydroxy-29-methoxy-3β-tetradecanoate-olean-12-ene, and 3β,24β-epoxy-29-methoxy-2α,3α,6α- -trihydroxy-D:A-friedelane that is reported for the first time as a natural product. This is the fir…
  • Lathyrane Diterpenes from the Latex of Euphorbia laurifolia. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):671-673.Durán-Peña MJ, Flores-Giubi ME, … Hernández-Galán R
  • Two new macrocyclic diterpenes, 2-epi-latazienone (4) and 15β-acetoxy-7β-nicotinoyloxy-3β,8α-di-(2-methylpropanoyloxy)-4αH,9αH,l1αH-lathyra- 5E,12E-dien-14-one (5), and three known lathyrane-type diterpenes (1-3) were isolated from Euphorbia laurifolia latex. Their structures were determined on the basis of a detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data.
  • Structure-Dependent Cytotoxic Effects of Eremophilanolide Sesquiterpenes. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):663-665.Agulló-Ortuño MT, Diaz CE, … Reina M
  • The aim of this research was to determine the cytotoxic action of sixteen structurally-related eremophilane-type sesquiterpenes, isolated from several species of Senecio, against a panel of cancer cell lines. The cytotoxic activities were evaluated by WST-I test and the ICso values calculated. The investigated compounds exerted dose-dependent cytotoxic actions against selected cancer cell lines a…
  • Antioxidant Activity of Carvone and Derivatives against Superoxide Ion. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):653-655.Pombal S, Hernández Y, … Rodilla JM
  • Carvone has corroborated its versatility as starting material for building blocks synthesis in organic chemistry, being achieved a new chiral lactone. It has been done a study on the antioxidant activity against superoxide of carvone and a chloro derivative that show the potent activity of the natural product (R)-carvone, 1.
  • Exploiting Substrate Diversity of NRPS Led to the Generation of New Sansanmycin Analogs. [Journal Article]
    Nat Prod Commun. 2017 May; 12(5):781-783.Wang SS, Zhang NN, … Xie YY
  • Further exploration of substrate diversity of the sansaninycin biosynthetic pathway using available halogen- and methyl-phenylalanines led to the generation of diverse sansanmycin derivatives, either at the single C- or N-terminus alone or at both C- and N-termini. The structures of all of these derivatives were determined by MS/MS spectra, and amongst them, the structures of [2-Cl-Phe]-sansanmyc…
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