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48,567 results
  • Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study. [Journal Article]
  • LNLancet Neurol 2018 Sep 12
  • Karoly PJ, Goldenholz DM, … Cook MJ
  • CONCLUSIONS: Our results suggest that seizure cycles are robust, patient specific, and more widespread than previously understood. They align with the accepted consensus that most epilepsies have some diurnal influence. Variations in seizure rate have important clinical implications. Detection and tracking of seizure cycles on a patient-specific basis should be standard in epilepsy management practices.
  • Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. [Journal Article]
  • NeurNeurology 2018 Sep 14
  • McDade E, Wang G, … Dominantly Inherited Alzheimer Network
  • CONCLUSIONS: These longitudinal estimates clarify the sequence and temporal dynamics of presymptomatic pathologic changes in autosomal dominant AD, information critical to a better understanding of the disease. The pattern of biomarker changes identified here also suggests that once β-amyloidosis begins, additional pathologies may begin to develop less than 10 years later, but more than 15 years before symptom onset, an important consideration for interventions meant to alter the disease course.
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