- Antiresorptive therapy influence on peri-implant diseases: Clinical implications and osteoimmunological perspectives. [Review]Periodontol 2000. 2026 Sep 16. [Online ahead of print]P2
- CONCLUSIONS: Antiresorptive therapy should not be regarded as an absolute contraindication to implant therapy in appropriately selected patients, particularly those receiving osteoporosis-dose regimens. However, chronic peri-implant inflammation, repeated surgical intervention, and high-dose oncologic antiresorptive exposure may impair osteoimmune adaptation and increase susceptibility to delayed healing and MRONJ-related complications.
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- From mouth to brain: Linking periodontal and peri-implant dysbiosis to systemic inflammation and neuropathology. [Review]Periodontol 2000. 2026 Sep 16. [Online ahead of print]P2
- CONCLUSIONS: Elucidating the intricate interactions between oral dysbiosis, periodontal diseases, chronic inflammation, and neurodegeneration is essential for understanding oral health's systemic implications for neurodegenerative and age-related diseases. Current evidence supports an association between oral dysbiosis, chronic oral inflammation, and pathways relevant to neurodegeneration, particularly for periodontitis. However, important knowledge gaps remain, especially concerning peri-implant diseases, where human data are limited.
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- Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta-analysis. [Review]Periodontol 2000. 2026 Sep 15. [Online ahead of print]P2
- CONCLUSIONS: Adjunctive CHX in nonsurgical periodontal therapy provides modest but outcome-specific benefits, mainly limited to inflammatory parameters, with no clear additional effect on attachment outcomes. In surgical therapy, the qualitative analysis seems to support early postoperative plaque control and inflammation control, while evidence for an effect on later healing remains limited.
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- Understanding exosomes: A history of EV-erything. [Review]Periodontol 2000. 2026 Sep 08. [Online ahead of print]P2
- CONCLUSIONS: The history of EV research reflects a remarkable transition from observations of poorly understood extracellular particles to the recognition of EVs as key modulators of biological communication and potential therapeutic systems. As technological capabilities, standardization efforts, and translational applications continue to advance, EVs are poised to play an increasingly important role in the future of precision medicine.
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- Dentifrice formulations for the treatment of dentin hypersensitivity: A systematic review and network meta-analysis. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Stannous fluoride and arginine dentifrices should be considered first-line self-care options for DH.
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- Mapping the omics landscape for peri-implant diseases: A scoping review. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Current omics evidence suggests that peri-implant disease follows a staged, implant-conditioned biological trajectory rather than a simple binary healthy/diseased model.
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- Understanding extracellular vesicles in antiaging. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: EVs represent promising therapeutic agents and biomarkers in aging biology, with the potential to regulate multiple hallmarks of aging concurrently. Prospective research should prioritize standardization, targeted bioengineering, and rigorous clinical validation to allow successful antiaging interventions.
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- Flapless submucosal instrumentation treatment of peri-implantitis: Contemporary evidence and clinical protocol. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Although the available evidence remains heterogeneous and is largely derived from nonrandomized studies, flapless submucosal instrumentation appears to be a biologically sound and minimally invasive option for selected peri-implantitis cases, which may be repeated when clinically indicated while acknowledging heterogeneous protocols and limited comparative evidence.
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- Individualized healing significantly improves pink esthetics around immediate single implants: A systematic review and meta-analysis. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Within the limitations of this study, PR significantly improved PES without compromising IS or MBL. Their use may be beneficial, especially in the esthetic region, but further studies are needed to investigate their cost-effectiveness and long-term effect, especially on horizontal tissue changes.
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- Oral health and systemic health outcomes: A call for interdisciplinary action. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Oral health must be recognized as integral to general health and embedded within NCD strategies and universal health coverage through interprofessional, intersectoral action that also tackles the social and commercial determinants and reduces inequalities.
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- Association of tooth wear with dentin hypersensitivity: A systematic review. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: This review provides evidence for a consistent association between DH and TW and some etiological factors, observed across patient- and tooth-level analyses.
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- Factors influencing the effectiveness of surgical therapy of peri-implantitis. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Outcomes of surgical peri-implantitis treatment are determined by a complex interplay of defect morphology, disease severity, implant surface characteristics, surgical expertise, and patient adherence to supportive care.
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- Guiding the AI revolution in periodontology and implant dentistry: Concepts, ethics, accountability, and a roadmap for sustainable adoption. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Use of AI has substantially improved periodontology and implant dentistry research. However, a sustainable clinical translation requires responsible implementation of the AI and a stronger data set that represents the multimodal nature of the periodontal and peri-implant diseases. Moving forward, the data sets being used to train the models need to be multimodal, multicenter, and clinically verified to support the generalizability of the findings. In addition, there needs to be clear ethical safeguards and clinician oversight to make sure the results are interpreted in the correct way.
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- Soft tissue grafting for the prevention and management of peri-implantitis. [Review]Periodontol 2000. 2026 Aug 31. [Online ahead of print]P2
- CONCLUSIONS: Soft tissue grafting is a clinically relevant, phenotype-modifying strategy for preventing and managing peri-implant diseases. Risk-based, phenotype-driven decision-making (distinguishing KPIM augmentation from targeted STT augmentation) is essential for optimizing treatment outcomes.
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- Diagnostic use of extracellular vesicles in dentistry. [Review]Periodontol 2000. 2026 Aug 25. [Online ahead of print]P2
- CONCLUSIONS: Oral-fluid EVs represent a compelling but early-stage diagnostic platform in dentistry. Their successful translation will require rigorous methodological standardization, MISEV-aligned reporting, robust analytical and clinical validation, and deployment strategies suited to either point-of-care or centralized laboratory testing.
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