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Unbound Medicine.
(Phytotherapy research[TA])
5,585 results
  • Macrophage polarization by phytotherapy in the tumor microenvironment. [Review]
    Phytother Res. 2021 Feb 25 [Online ahead of print]Saeedifar AM, Mosayebi G, … Ganji A
  • Several signaling pathways were involved in M1 (classic) and M2 (alternative) macrophage polarization. Disruption of M2-related signaling pathways and improvement of M1-related signaling pathways can be identified as one of the cancer therapeutic approaches. Prevention of macrophage differentiation into M2 by different herbal agents with antitumor properties can be considered as a promising thera…
  • Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma. [Journal Article]
    Phytother Res. 2021 Feb 23 [Online ahead of print]Hooshmand S, Mahdinezhad MR, … Ghorbani A
  • Morus nigra is a rich source of anthocyanins, phytochemicals that have anticancer effects. This study aimed to investigate the effects of M. nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC). Male Sprague-Dawley rats were assigned into four groups (n = 10): control, DEN, and DEN +100 or 400 mg/kg of MNE. After 4 months, the DEN group showed a significant morta…
  • Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting). [Review]
    Phytother Res. 2021 Feb 22 [Online ahead of print]Ghasemi S, Xu S, … Lorigooini Z
  • Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such …
  • The genus Cassia L.: Ethnopharmacological and phytochemical overview. [Review]
    Phytother Res. 2020 Dec 04 [Online ahead of print]Khurm M, Wang X, … Guo Z
  • Nature gifts medicinal plants with the untapped and boundless treasure of active chemical constituents with significant therapeutic potential that makes these plants a beneficial source in the development of phytomedicines. Genus Cassia, with approximately 500 species, is a large group of flowering plants in the family Fabaceae. Cassia species are widely distributed throughout different regions m…
  • Medicinal plants: Treasure for antiviral drug discovery. [Review]
    Phytother Res. 2021 Feb 16 [Online ahead of print]Ali SI, Sheikh WM, … Nabi SU
  • The pandemic of viral diseases like novel coronavirus (2019-nCoV) prompted the scientific world to examine antiviral bioactive compounds rather than nucleic acid analogous, protease inhibitors, or other toxic synthetic molecules. The emerging viral infections significantly associated with 2019-nCoV have challenged humanity's survival. Further, there is a constant emergence of new resistant viral …
  • Antiangiogenic properties of lichen secondary metabolites. [Review]
    Phytother Res. 2021 Feb 15 [Online ahead of print]Ulus G
  • Lichens are symbiotic organisms which are composed fungi and algae and/or cyanobacteria. They produce a variety of characteristic secondary metabolites. Such substances have various biological properties including antimicrobial, antiviral, and antitumor activities. Angiogenesis, the growth of new vessels from pre-existing vessels, contributes to numerous diseases including cancer, arthritis, athe…
  • Curcumin nanoformulations for antimicrobial and wound healing purposes. [Review]
    Phytother Res. 2021 Feb 15 [Online ahead of print]Salehi B, Rodrigues CF, … Cruz-Martins N
  • The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities …
  • New insights into the role of the Nrf2 signaling pathway in green tea catechin applications. [Review]
    Phytother Res. 2021 Feb 10 [Online ahead of print]Talebi M, Talebi M, … Samarghandian S
  • Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes mellitus, renal injuries, respiratory conditions, gastrointestinal disturbances, and general disorders related to oxidative…
  • Berberine-A potent chemosensitizer and chemoprotector to conventional cancer therapies. [Review]
    Phytother Res. 2021 Feb 08 [Online ahead of print]Devarajan N, Jayaraman S, … Ganesan SK
  • Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their clinical outcomes are highly limited by the resistance of malignant tumors to these therapies and the incurrence of serious damages in vital organs. This in turn necessitates the development of adjunct drugs that overcomes chemo/radioresistance in refractory cancers and protects vital organs from the cytotox…
  • Spices and herbs: Potential antiviral preventives and immunity boosters during COVID-19. [Journal Article]
    Phytother Res. 2021 Jan 29 [Online ahead of print]Singh NA, Kumar P, … Kumar N
  • A severe acute respiratory syndrome is an unusual type of contagious pneumonia that is caused by SARS coronavirus. At present, the whole world is trying to combat this coronavirus disease and scientific communities are putting rigorous efforts to develop vaccines. However, there are only a few specific medical treatments for SARS-CoV-2. Apart from other public health measures taken to prevent thi…
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