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1,102 results
  • Expression of cell cycle regulators and biomarkers of proliferation and regrowth in human pituitary adenomas. [Journal Article]
  • PPituitary 2017 Mar 24
  • Gruppetta M, Formosa R, … Vassallo J
  • CONCLUSIONS: Interesting and novel observations on the differences in expression of tumour markers studied are reported. Correlation between Ki-67 expression, PTTG nuclear expression and recurrence/regrowth of PAs, emphasizes the role that Ki-67 and PTTG expression have as markers of increased proliferation. c-MYC and PTTG nuclear expression levels were correlated providing evidence that PTTG induces c-MYC expression in PAs and we propose that c-MYC might principally have a role in early pituitary tumorigenesis. Evidence is shown that the anti-proliferative effect of somatostatin analogue treatment in vivo occurs through regulation of the cell cycle.
  • Sellar and clival plasmacytomas: case series of 5 patients with systematic review of 65 published cases. [Review]
  • PPituitary 2017 Mar 01
  • Lee J, Kulubya E, … Cooper O
  • CONCLUSIONS: Parasellar plasmacytomas are rare tumors that should be considered in the differential diagnosis for lesions involving the sella and arising from the clivus, especially when cranial nerve paresis is apparent, even in the absence of known MM. Although recurrence rates for parasellar plasmacytoma is low, patients should be monitored for progression to MM. Treatment depends on the presence of systemic disease at diagnosis.
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