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(Progress in retinal and eye research[TA])
809 results
  • Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities. [Review]
    Prog Retin Eye Res. 2021 Nov 25 [Online ahead of print]Schneider N, Sundaresan Y, … Sharon D
  • Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual impairment phenotypes caused by pathogenic variants in at least 277 nuclear and mitochondrial genes, affecting different retinal regions, and depleting the vision of affected individuals. Genes that cause IRDs when mutated are unique by possessing differing genotype-phenotype correlations, varying inherita…
  • Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis. [Review]
    Prog Retin Eye Res. 2021 Nov 20 [Online ahead of print]Singh RB, Das S, … Jhanji V
  • Bacterial keratitis continues to be one of the leading causes of corneal blindness in the developed as well as the developing world, despite swift progress since the dawn of the "anti-biotic era". Although, we are expeditiously developing our understanding about the different causative organisms and associated pathology leading to keratitis, extensive gaps in knowledge continue to dampen the effo…
  • Age and intraocular pressure in murine experimental glaucoma. [Review]
    Prog Retin Eye Res. 2021 Nov 18 [Online ahead of print]Johnny DP, Henderson DCM, … Chauhan BC
  • Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. While IOP is commonly considered in models of experimental glaucoma (EG), most studies use juvenile or adult animals and seldom older animals which are representative of the human disease. This paper provides a concise review of how retinal ganglion cell (RGC) los…
  • Reticular pseudodrusen: A critical phenotype in age-related macular degeneration. [Review]
    Prog Retin Eye Res. 2021 Nov 06 [Online ahead of print]Wu Z, Fletcher EL, … Guymer RH
  • Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct lesions that occur in the subretinal space. Over the past three decades, their presence in association with age-related macular degeneration (AMD) has become increasingly recognized, especially as RPD have become more easily distinguished with newer clinical imaging modalities. There is also an increasing appr…
  • Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets. [Journal Article]
    Prog Retin Eye Res. 2021 Nov 02 [Online ahead of print]Karamichos D, Escandon P, … Riaz KM
  • "The Diseases of the Horny-coat of The Eye", known today as keratoconus, is a progressive, multifactorial, non-inflammatory ectatic corneal disorder that is characterized by steepening (bulging) and thinning of the cornea, irregular astigmatism, myopia, and scarring that can cause devastating vision loss. The significant socioeconomic impact of the disease is immeasurable, as patients with kerato…
  • The role of dark adaptation in understanding early AMD. [Review]
    Prog Retin Eye Res. 2021 Oct 06 [Online ahead of print]Murray IJ, Rodrigo-Diaz E, … Parry NR
  • The main aim of the paper is to discuss current knowledge on how Age Related Macular Degeneration (AMD) affects Dark Adaptation (DA). The paper is divided into three parts. Firstly, we outline some of the molecular mechanisms that control DA. Secondly, we review the psychophysical issues and the corresponding analytical techniques. Finally, we characterise the link between slowed DA and the morph…
  • Recent understanding of binocular vision in the natural environment with clinical implications. [Review]
    Prog Retin Eye Res. 2021 Oct 06 [Online ahead of print]Candy TR, Cormack LK
  • Technological advances in recent decades have allowed us to measure both the information available to the visual system in the natural environment and the rich array of behaviors that the visual system supports. This review highlights the tasks undertaken by the binocular visual system in particular and how, for much of human activity, these tasks differ from those considered when an observer fix…
  • Retinal pigment epithelium 65 kDa protein (RPE65): An update. [Review]
    Prog Retin Eye Res. 2021 Oct 02 [Online ahead of print]Kiser PD
  • Vertebrate vision critically depends on an 11-cis-retinoid renewal system known as the visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment epithelium 65 kDa protein (RPE65), which catalyzes an unusual, possibly biochemically unique, reaction consisting of a coupled all-trans-retinyl ester hydrolysis and alkene geometric isomerization to produce 11-cis-retino…
  • Protection against corneal hyperosmolarity with soft-contact-lens wear. [Review]
    Prog Retin Eye Res. 2021 Sep 29 [Online ahead of print]Kim YH, Nguyen T, … Radke CJ
  • Hyperosmotic tear stimulates human corneal nerve endings, activates ocular immune response, and elicits dry-eye symptoms. A soft contact lens (SCL) covers the cornea preventing it from experiencing direct tear evaporation and the resulting blink-periodic salinity increases. For the cornea to experience hyperosmolarity due to tear evaporation, salt must transport across the SCL to the post-lens te…
  • Regenerative therapy for the Cornea. [Review]
    Prog Retin Eye Res. 2021 Sep 14 [Online ahead of print]Kumar A, Yun H, … Du Y
  • The cornea is the outmost layer of the eye, unique in its transparency and strength. The cornea not only transmits the light essential for vision, also refracts light, giving focus to images. Each of the three layers of the cornea has properties essential for the function of vision. Although the epithelium can often recover from injury quickly by cell division, loss of limbal stem cells can cause…
  • Of men and mice: Human X-linked retinoschisis and fidelity in mouse modeling. [Review]
    Prog Retin Eye Res. 2021 Aug 11 [Online ahead of print]Vijayasarathy C, Sardar Pasha SPB, Sieving PA
  • X-linked Retinoschisis (XLRS) is an early-onset transretinal dystrophy, often with a prominent macular component, that affects males and generally spares heterozygous females because of X-linked recessive inheritance. It results from loss-of-function RS1 gene mutations on the X-chromosome. XLRS causes bilateral reduced acuities from young age, and on clinical exam and by ocular coherence tomograp…
  • Choriocapillaris: Fundamentals and advancements. [Review]
    Prog Retin Eye Res. 2021 Jul 19 [Online ahead of print]Lejoyeux R, Benillouche J, … Chhablani J
  • The choriocapillaris is the innermost structure of the choroid that directly nourishes the retinal pigment epithelium and photoreceptors. This article provides an overview of its hemovasculogenesis development to achieve its final architecture as a lobular vasculature, and also summarizes the current histological and molecular knowledge about choriocapillaris and its dysfunction. After describing…
  • Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease. [Review]
    Prog Retin Eye Res. 2021 Jul 17 [Online ahead of print]Brinks J, van Dijk EHC, … Boon CJF
  • The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood. Recent advances in the field of single-cell RNA sequencing have yielded valuable insights into the properties of choroidal endothelial cells (CECs). Here, we review the role of the choroid in various physiological and pathophysiological mechan…
  • Approaches for corneal endothelium regenerative medicine. [Review]
    Prog Retin Eye Res. 2021 Jul 06 [Online ahead of print]Català P, Thuret G, … Dickman MM
  • The state of the art therapy for treating corneal endothelial disease is transplantation. Advances in the reproducibility and accessibility of surgical techniques are increasing the number of corneal transplants, thereby causing a global deficit of donor corneas and leaving 12.7 million patients with addressable visual impairment. Approaches to regenerate the corneal endothelium offer a solution …
  • AI-based monitoring of retinal fluid in disease activity and under therapy. [Review]
    Prog Retin Eye Res. 2021 Jun 22 [Online ahead of print]Schmidt-Erfurth U, Reiter GS, … Bogunović H
  • Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by high-resolution three-dimensional optical coherence tomography (OCT), which is used world-wide as a diagnostic gold standard largely replacing clinical examination. Artificial intelligence (AI) with its capability to objectively identify, localize and quantify fluid introduces fully automated tools into …
  • Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic. [Review]
    Prog Retin Eye Res. 2021 Jun 05 [Online ahead of print]Cordeiro MF, Hill D, … Younis S
  • DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that has been developed within the last 2 decades from basic laboratory science to Phase 2 clinical trials. It uses ANX776 (fluorescently labelled Annexin A5) to identify stressed and apoptotic cells in the living eye. During its development, DARC has undergone biochemistry optimisation, scale-up and GMP manufacture and …
  • Müller cells and astrocytes in tractional macular disorders. [Review]
    Prog Retin Eye Res. 2021 Jun 05 [Online ahead of print]Bringmann A, Unterlauft JD, … Wiedemann P
  • Tractional deformations of the fovea mainly arise from an anomalous posterior vitreous detachment and contraction of epiretinal membranes, and also occur in eyes with cystoid macular edema or high myopia. Traction to the fovea may cause partial- and full-thickness macular defects. Partial-thickness defects are foveal pseudocysts, macular pseudoholes, and tractional, degenerative, and outer lamell…
  • The two-faced effects of nerves and neuropeptides in corneal diseases. [Review]
    Prog Retin Eye Res. 2021 Jun 07 [Online ahead of print]Lasagni Vitar RM, Rama P, Ferrari G
  • Corneal nerves are instrumental to maintain cornea integrity through regulation of key physiological functions such as tear secretion, blink reflex, and neuropeptide turnover. Corneal nerve injury/stimulation can follow many insults including mechanical/chemical trauma, infections and surgeries. Nerve disruption initiates a process named neurogenic inflammation which leads to edema, pain, and rec…
  • Early and late stage gene therapy interventions for inherited retinal degenerations. [Review]
    Prog Retin Eye Res. 2021 May 29 [Online ahead of print]Botto C, Rucli M, … Dalkara D
  • Inherited and age-related retinal degeneration is the hallmark of a large group of heterogeneous diseases and is the main cause of untreatable blindness today. Genetic factors play a major pathogenic role in retinal degenerations for both monogenic diseases (such as retinitis pigmentosa) and complex diseases with established genetic risk factors (such as age-related macular degeneration). Progres…
  • Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders. [Review]
    Prog Retin Eye Res. 2021 May 21 [Online ahead of print]Spaide RF, Gemmy Cheung CM, … Maloca PM
  • In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal vascular hyperpermeability, but the etiology for the fluid is controversial. The choroidal vascular findings as elucidated by recent optical coherence tomography (OCT) and wide-field indocyanine green (ICG) angiogr…
  • Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options. [Review]
    Prog Retin Eye Res. 2021 May 17 [Online ahead of print]Brouwer NJ, Verdijk RM, … Jager MJ
  • Recent developments in oncology have led to a better molecular and cellular understanding of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare but potentially devastating disease. A better understanding of CoM, leading to the development of novel therapies, is urgently needed. CoM is characterized by mutations that have also been identified in cutaneous melano…
  • Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies. [Review]
    Prog Retin Eye Res. 2021 Nov; 85:100970.Eastlake K, Lamb WDB, … Limb GA
  • Neural cell death is the main feature of all retinal degenerative disorders that lead to blindness. Despite therapeutic advances, progression of retinal disease cannot always be prevented, and once neuronal cell damage occurs, visual loss cannot be reversed. Recent research in the stem cell field, and the identification of Müller glia with stem cell characteristics in the human eye, have provided…
  • Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology. [Review]
    Prog Retin Eye Res. 2021 Nov; 85:100968.Strub T, Martel A, … Bertolotto C
  • Uveal melanoma (UM) is an aggressive and deadly neoplasm. In recent decades, great efforts have been made to obtain a more comprehensive understanding of genetics, genomics and molecular changes in UM, enabling the identification of key cellular processes and signalling pathways. Still, there is no effective treatment for the metastatic disease. Intratumoural heterogeneity (ITH) is thought to be …
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