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(Progress in retinal and eye research[TA])
792 results
  • Choriocapillaris: Fundamentals and advancements. [Review]
    Prog Retin Eye Res. 2021 Jul 19 [Online ahead of print]Lejoyeux R, Benillouche J, … Chhablani J
  • The choriocapillaris is the innermost structure of the choroid that directly nourishes the retinal pigment epithelium and photoreceptors. This article provides an overview of its hemovasculogenesis development to achieve its final architecture as a lobular vasculature, and also summarizes the current histological and molecular knowledge about choriocapillaris and its dysfunction. After describing…
  • Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease. [Review]
    Prog Retin Eye Res. 2021 Jul 17 [Online ahead of print]Brinks J, van Dijk EHC, … Boon CJF
  • The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood. Recent advances in the field of single-cell RNA sequencing have yielded valuable insights into the properties of choroidal endothelial cells (CECs). Here, we review the role of the choroid in various physiological and pathophysiological mechan…
  • Approaches for corneal endothelium regenerative medicine. [Review]
    Prog Retin Eye Res. 2021 Jul 06 [Online ahead of print]Català P, Thuret G, … Dickman MM
  • The state of the art therapy for treating corneal endothelial disease is transplantation. Advances in the reproducibility and accessibility of surgical techniques are increasing the number of corneal transplants, thereby causing a global deficit of donor corneas and leaving 12.7 million patients with addressable visual impairment. Approaches to regenerate the corneal endothelium offer a solution …
  • AI-based monitoring of retinal fluid in disease activity and under therapy. [Review]
    Prog Retin Eye Res. 2021 Jun 22 [Online ahead of print]Schmidt-Erfurth U, Reiter GS, … Bogunović H
  • Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by high-resolution three-dimensional optical coherence tomography (OCT), which is used world-wide as a diagnostic gold standard largely replacing clinical examination. Artificial intelligence (AI) with its capability to objectively identify, localize and quantify fluid introduces fully automated tools into …
  • Detecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic. [Review]
    Prog Retin Eye Res. 2021 Jun 05 [Online ahead of print]Cordeiro MF, Hill D, … Younis S
  • DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that has been developed within the last 2 decades from basic laboratory science to Phase 2 clinical trials. It uses ANX776 (fluorescently labelled Annexin A5) to identify stressed and apoptotic cells in the living eye. During its development, DARC has undergone biochemistry optimisation, scale-up and GMP manufacture and …
  • Müller cells and astrocytes in tractional macular disorders. [Review]
    Prog Retin Eye Res. 2021 Jun 05 [Online ahead of print]Bringmann A, Unterlauft JD, … Wiedemann P
  • Tractional deformations of the fovea mainly arise from an anomalous posterior vitreous detachment and contraction of epiretinal membranes, and also occur in eyes with cystoid macular edema or high myopia. Traction to the fovea may cause partial- and full-thickness macular defects. Partial-thickness defects are foveal pseudocysts, macular pseudoholes, and tractional, degenerative, and outer lamell…
  • The two-faced effects of nerves and neuropeptides in corneal diseases. [Review]
    Prog Retin Eye Res. 2021 Jun 07 [Online ahead of print]Lasagni Vitar RM, Rama P, Ferrari G
  • Corneal nerves are instrumental to maintain cornea integrity through regulation of key physiological functions such as tear secretion, blink reflex, and neuropeptide turnover. Corneal nerve injury/stimulation can follow many insults including mechanical/chemical trauma, infections and surgeries. Nerve disruption initiates a process named neurogenic inflammation which leads to edema, pain, and rec…
  • Early and late stage gene therapy interventions for inherited retinal degenerations. [Review]
    Prog Retin Eye Res. 2021 May 29 [Online ahead of print]Botto C, Rucli M, … Dalkara D
  • Inherited and age-related retinal degeneration is the hallmark of a large group of heterogeneous diseases and is the main cause of untreatable blindness today. Genetic factors play a major pathogenic role in retinal degenerations for both monogenic diseases (such as retinitis pigmentosa) and complex diseases with established genetic risk factors (such as age-related macular degeneration). Progres…
  • Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders. [Review]
    Prog Retin Eye Res. 2021 May 21 [Online ahead of print]Spaide RF, Gemmy Cheung CM, … Maloca PM
  • In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal vascular hyperpermeability, but the etiology for the fluid is controversial. The choroidal vascular findings as elucidated by recent optical coherence tomography (OCT) and wide-field indocyanine green (ICG) angiogr…
  • Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options. [Review]
    Prog Retin Eye Res. 2021 May 17 [Online ahead of print]Brouwer NJ, Verdijk RM, … Jager MJ
  • Recent developments in oncology have led to a better molecular and cellular understanding of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare but potentially devastating disease. A better understanding of CoM, leading to the development of novel therapies, is urgently needed. CoM is characterized by mutations that have also been identified in cutaneous melano…
  • Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies. [Review]
    Prog Retin Eye Res. 2021 Apr 28 [Online ahead of print]Eastlake K, Lamb WDB, … Limb GA
  • Neural cell death is the main feature of all retinal degenerative disorders that lead to blindness. Despite therapeutic advances, progression of retinal disease cannot always be prevented, and once neuronal cell damage occurs, visual loss cannot be reversed. Recent research in the stem cell field, and the identification of Müller glia with stem cell characteristics in the human eye, have provided…
  • Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology. [Review]
    Prog Retin Eye Res. 2021 Apr 13 [Online ahead of print]Strub T, Martel A, … Bertolotto C
  • Uveal melanoma (UM) is an aggressive and deadly neoplasm. In recent decades, great efforts have been made to obtain a more comprehensive understanding of genetics, genomics and molecular changes in UM, enabling the identification of key cellular processes and signalling pathways. Still, there is no effective treatment for the metastatic disease. Intratumoural heterogeneity (ITH) is thought to be …
  • Mesenchymal stromal cells for the treatment of ocular autoimmune diseases. [Journal Article]
    Prog Retin Eye Res. 2021 Mar 26 [Online ahead of print]Oh JY, Lee RH
  • Mesenchymal stromal cells, commonly referred to as MSCs, have emerged as a promising cell-based therapy for a range of autoimmune diseases thanks to several therapeutic advantages. Key among these are: 1) the ability to modulate innate and adaptive immune responses and to promote tissue regeneration, 2) the ease of their isolation from readily accessible tissues and expansion at scale in culture,…
  • Artificial intelligence in OCT angiography. [Review]
    Prog Retin Eye Res. 2021 Mar 22 [Online ahead of print]Hormel TT, Hwang TS, … Jia Y
  • Optical coherence tomographic angiography (OCTA) is a non-invasive imaging modality that provides three-dimensional, information-rich vascular images. With numerous studies demonstrating unique capabilities in biomarker quantification, diagnosis, and monitoring, OCTA technology has seen rapid adoption in research and clinical settings. The value of OCTA imaging is significantly enhanced by image …
  • Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula. [Review]
    Prog Retin Eye Res. 2021 Mar 11 [Online ahead of print]van Dijk EHC, Boon CJF
  • A wide range of ocular diseases can present with serous subretinal fluid in the macula and therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we categorise the diseases and conditions that are part of the differential diagnosis into 12 main pathogenic subgroups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular tumours, haematological mal…
  • Photocoagulation for retinal vein occlusion. [Review]
    Prog Retin Eye Res. 2021 Mar 11 [Online ahead of print]Hayreh SS
  • The role of photocoagulation in retinal vein occlusion (RVO) has been studied since 1974. The most serious complications of central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) are: (i) visual deterioration, most commonly due to macular edema, and (ii) the development of ocular neovascularization (NV), particularly neovascular glaucoma (NVG), with hazardous consequences …
  • Human limbal epithelial stem cell regulation, bioengineering and function. [Review]
    Prog Retin Eye Res. 2021 Mar 04 [Online ahead of print]Bonnet C, González S, … Deng SX
  • The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opac…
  • VEGFR1 signaling in retinal angiogenesis and microinflammation. [Review]
    Prog Retin Eye Res. 2021 Feb 25 [Online ahead of print]Uemura A, Fruttiger M, … Langmann T
  • Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, -C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas VEGF-B and PlGF only bind VEGFR1. Although much research has been conducted on VEGFR2 to elucidate its key role in retinal diseases, recent efforts have shown the importance and involvement of …
  • Adaptive responses to neurodegenerative stress in glaucoma. [Review]
    Prog Retin Eye Res. 2021 Feb 25 [Online ahead of print]Calkins DJ
  • Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC) projection to the brain. The disease is characterized by sensitivity to intraocular pressure (IOP) conveyed at the optic nerve head, through which RGC axons pass unmyelinated to form the optic nerve. From this point, a pathogenic triumvirate comprising inflammatory, oxidative, and metabolic stress influence bot…
  • Implications of genetic variation in the complement system in age-related macular degeneration. [Review]
    Prog Retin Eye Res. 2021 Feb 19 [Online ahead of print]de Jong S, Gagliardi G, … den Hollander AI
  • Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was identified as one of the main pathways contributing to disease risk. The strong link between the complement system and AMD was demonstrated by genetic associations, and by elevated complement activation in local eye tissue…
  • Immunological aspects of RPE cell transplantation. [Review]
    Prog Retin Eye Res. 2021 Jan 19 [Online ahead of print]Sugita S, Mandai M, … Takahashi M
  • Retinal pigment epithelial (RPE) cells have several functions, including support of the neural retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly suppress inflammatory immune cells. For instance, they directly suppress the activation of T cells in vitro. In contrast, transplanted allogeneic human RPE cells are rejected by bystander immune cells such as T cells …
  • Past, present and future role of retinal imaging in neurodegenerative disease. [Review]
    Prog Retin Eye Res. 2021 Jul; 83:100938.Kashani AH, Asanad S, … Ringman JM
  • Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as opti…
  • The innate immune system in diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2021 Jan 08 [Online ahead of print]Pan WW, Lin F, Fort PE
  • The prevalence of diabetes has been rising steadily in the past half-century, along with the burden of its associated complications, including diabetic retinopathy (DR). DR is currently the most common cause of vision loss in working-age adults in the United States. Historically, DR has been diagnosed and classified clinically based on what is visible by fundoscopy; that is vasculature alteration…
  • Uncoupling proteins in the mitochondrial defense against oxidative stress. [Review]
    Prog Retin Eye Res. 2021 Jul; 83:100941.Hass DT, Barnstable CJ
  • Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-oxidative strategies have been insufficient at counteracting one of the predominant intrinsic sources of reactive oxygen species (ROS), mitochondria. The proton gradient across the inner mitochondrial membrane is a key driving force for mitochondrial ROS production, and this gradient can be modulated by memb…
  • Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. [Review]
    Prog Retin Eye Res. 2021 Jul; 83:100934.Voigt AP, Mullin NK, … Mullins RF
  • Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand retinal physiology and disease. With the advent of single-cell RNA sequencing, expression experiments provide an unparalleled resolution of information. Instead of studying aggregated gene expression across all cells in a heterogenous tiss…
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