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(Progress in retinal and eye research[TA])
727 results
  • Personalising surgical treatments for glaucoma patients. [Review]
    Prog Retin Eye Res. 2020 Jun 17 [Online ahead of print]Megevand GS, Bron AM
  • Surgical treatments for glaucoma have relied for decades on traditional filtering surgery such as trabeculectomy and, in more challenging cases, tubes. Antifibrotics were introduced to improve surgical success in patients at increased risk of failure but have been shown to be linked to a greater incidence of complications, some being potentially vision-threatening. As our understanding of glaucom…
  • Splicing mutations in inherited retinal diseases. [Review]
    Prog Retin Eye Res. 2020 Jun 15 [Online ahead of print]Weisschuh N, Buena-Atienza E, Wissinger B
  • Mutations which induce aberrant transcript splicing represent a distinct class of disease-causing genetic variants in retinal disease genes. Such mutations may either weaken or erase regular splice sites or create novel splice sites which alter exon recognition. While mutations affecting the canonical GU-AG dinucleotides at the splice donor and splice acceptor site are highly predictive to cause …
  • Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis. [Journal Article]
    Prog Retin Eye Res. 2020 May 08 [Online ahead of print]Ong Tone S, Kocaba V, … Jurkunas UV
  • Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal endothelial dystrophy and the leading indication for corneal transplantation worldwide. FECD is characterized by the progressive decline of corneal endothelial cells (CECs) and the formation of extracellular matrix (ECM) excrescences in Descemet's membrane (DM), called guttae, that lead to corneal edema and loss of visi…
  • Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. [Review]
    Prog Retin Eye Res. 2020 May 16 [Online ahead of print]Zhong Z, Su G, … Yang P
  • Uveitis is a group of diseases characterized by intraocular inflammation, of which some are driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada disease, Behçet's disease, uveitis associated with spondyloarthritis, ocular sarcoidosis, sympathetic ophthalmia and birdshot chorioretinopathy. These entities have various clinical forms, but genetic and biomarker data sugges…
  • Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities. [Review]
    Prog Retin Eye Res. 2020 May 11 [Online ahead of print]Kaye R, Chandra S, … Lotery A
  • Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hyp…
  • Molecular components affecting ocular carotenoid and retinoid homeostasis. [Journal Article]
    Prog Retin Eye Res. 2020 Apr 25 [Online ahead of print]von Lintig J, Moon J, Babino D
  • The photochemistry of vision employs opsins and geometric isomerization of their covalently bound retinylidine chromophores. In different animal classes, these light receptors associate with distinct G proteins that either hyperpolarize or depolarize photoreceptor membranes. Vertebrates also use the acidic form of chromophore, retinoic acid, as the ligand of nuclear hormone receptors that orchest…
  • Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. [Journal Article]
    Prog Retin Eye Res. 2020 Apr 13 [Online ahead of print]Kaarniranta K, Uusitalo H, … Ferrington D
  • Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are constantly exposed to oxidative stress that may lead to the accumulation of damaged cellular proteins, lipids, nucleic acids, and cellular organelles, including mitochondria. The ubiquitin-proteasome and the lysosomal/autophagy…
  • Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations. [Review]
    Prog Retin Eye Res. 2020 Apr 09 [Online ahead of print]Cremers FPM, Lee W, … Allikmets R
  • The ABCA4 protein (then called a "rim protein") was first identified in 1978 in the rims and incisures of rod photoreceptors. The corresponding gene, ABCA4, was cloned in 1997, and variants were identified as the cause of autosomal recessive Stargardt disease (STGD1). Over the next two decades, variation in ABCA4 has been attributed to phenotypes other than the classically defined STGD1 or fundus…
  • Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration. [Review]
    Prog Retin Eye Res. 2020 Apr 09 [Online ahead of print]Paraoan L, Sharif U, … Grierson I
  • Secretory proteostasis integrates protein synthesis, processing, folding and trafficking pathways that are essential for efficient cellular secretion. For the retinal pigment epithelium (RPE), secretory proteostasis is of vital importance for the maintenance of the structural and functional integrity of apical (photoreceptors) and basal (Bruch's membrane/choroidal blood supply) sides of the envir…
  • Endoplasmic reticulum stress: New insights into the pathogenesis and treatment of retinal degenerative diseases. [Review]
    Prog Retin Eye Res. 2020 Apr 06 [Online ahead of print]Gorbatyuk MS, Starr CR, Gorbatyuk OS
  • Physiological equilibrium in the retina depends on coordinated work between rod and cone photoreceptors and can be compromised by the expression of mutant proteins leading to inherited retinal degeneration (IRD). IRD is a diverse group of retinal dystrophies with multifaceted molecular mechanisms that are not fully understood. In this review, we focus on the contribution of chronically activated …
  • Extracellular vesicle therapy for retinal diseases. [Review]
    Prog Retin Eye Res. 2020 Mar 10 [Online ahead of print]Mead B, Tomarev S
  • Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more rece…
  • Iatrogenic ophthalmic artery occlusion and retinal artery occlusion. [Review]
    Prog Retin Eye Res. 2020 Mar 10 [Online ahead of print]Lee JS, Kim JY, … Woo SJ
  • Iatrogenic ophthalmic artery occlusion (IOAO) is a rare but devastating ophthalmic disease that may cause sudden and permanent visual loss. Understanding the possible etiologic modalities and pathogenic mechanisms of IOAO may prevent its occurrence. There are numerous medical etiologies of IOAO, including cosmetic facial filler injection, intravascular procedures, intravitreal gas or drug injecti…
  • Vitreous and Vision Degrading Myodesopsia. [Journal Article]
    Prog Retin Eye Res. 2020 Mar 06 [Online ahead of print]Sebag J
  • Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state, transparency, and physiologic function(s) within the eye. Myopia and aging alter collagen and hyaluronan association causing concurrent gel liquefaction and fibrous degeneration. The resulting vitreous opacities and collapse of the vitreous body during posterior vitreous detachment are the most common causes for t…
  • The cell biology of the retinal pigment epithelium. [Review]
    Prog Retin Eye Res. 2020 Feb 24 [Online ahead of print]Lakkaraju A, Umapathy A, … Williams DS
  • The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology o…
  • No flow through the vitreous humor: How strong is the evidence? [Review]
    Prog Retin Eye Res. 2020 Feb 06 [Online ahead of print]Smith DW, Lee CJ, Gardiner BS
  • When analyzing vitreal drug delivery, or the pharmacological effects of drugs on intraocular pressure, or when interpreting outflow facility measurements, it is generally accepted that the fluid in the vitreous humor is stagnant. It is accepted that for all practical purposes, the aqueous fluid exits the eye via anterior pathways only, and so there is negligible if any posteriorly directed flow o…
  • Cell types and cell circuits in human and non-human primate retina. [Review]
    Prog Retin Eye Res. 2020 Feb 05 [Online ahead of print]Grünert U, Martin PR
  • This review summarizes our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells and their connectivity. We have two main motivations in writing. Firstly, recent progress in non-invasive imaging methods to study retinal diseases mean that better understanding of the primate retina is becoming an important goal both for basic and for clinical sciences…
  • Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies. [Review]
    Prog Retin Eye Res. 2020 Jan 29 [Online ahead of print]Nielsen NS, Poulsen ET, … Enghild JJ
  • Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human TGFBIp. To date, 74 mutations in the transforming growth factor-β-induced gene (TGFBI) are associated with amylo…
  • Advances in the diagnosis and treatment of dry eye. [Review]
    Prog Retin Eye Res. 2020 Jan 29 [Online ahead of print]Kojima T, Dogru M, … Tsubota K
  • The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, an…
  • Ocular blood flow as a clinical observation: Value, limitations and data analysis. [Journal Article]
    Prog Retin Eye Res. 2020 Jan 24 [Online ahead of print]Harris A, Guidoboni G, … Arciero J
  • Alterations in ocular blood flow have been identified as important risk factors for the onset and progression of numerous diseases of the eye. In particular, several population-based and longitudinal-based studies have provided compelling evidence of hemodynamic biomarkers as independent risk factors for ocular disease throughout several different geographic regions. Despite this evidence, the re…
  • A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head. [Review]
    Prog Retin Eye Res. 2020 Jan 23 [Online ahead of print]Lee EJ, Han JC, … Kee C
  • Neuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change. However, the precise mechanism of the rim thinning has not been completely elucidated. This review focuses on the structural role of the glioarchitecture in the formation of the glaucomatous NRR thinning. The NRR is a glia-framed structure, with honeycomb geometry and mechanically reinforced astrocyte processes al…
  • Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. [Review]
    Prog Retin Eye Res. 2020 Jan 10 [Online ahead of print]Agrawal R, Ding J, … CVI.grid
  • The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced incons…
  • Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications. [Review]
    Prog Retin Eye Res. 2020 Jan 03 [Online ahead of print]Cuenca N, Ortuño-Lizarán I, … Pinilla I
  • Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks to its resolution and its ability to inform of the retinal state in seconds, which gives relevant information about retinal degeneration. In this review, we present an immunohistochemical description of the human and mice …
  • Age-related macular degeneration: A two-level model hypothesis. [Review]
    Prog Retin Eye Res. 2019 Dec 30 [Online ahead of print]Rozing MP, Durhuus JA, … Sørensen TL
  • Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pa…
  • Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis. [Review]
    Prog Retin Eye Res. 2019 Dec 28 [Online ahead of print]Jonas RA, Ung L, … Chodosh J
  • Known to occur in widespread outbreaks, epidemic keratoconjunctivitis (EKC) is a severe ocular surface infection with a strong historical association with human adenovirus (HAdV). While the conjunctival manifestations can vary from mild follicular conjunctivitis to hyper-acute, exudative conjunctivitis with formation of conjunctival membranes, EKC is distinct as the only form of adenovirus conjun…
  • Recapitulating developmental mechanisms for retinal regeneration. [Review]
    Prog Retin Eye Res. 2019 Dec 14 [Online ahead of print]Ahmad I, Teotia P, … Xia X
  • Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat b…
  • Evolution of the genes mediating phototransduction in rod and cone photoreceptors. [Review]
    Prog Retin Eye Res. 2019 Nov 29 [Online ahead of print]Lamb TD
  • This paper reviews current knowledge of the evolution of the multiple genes encoding proteins that mediate the process of phototransduction in rod and cone photoreceptors of vertebrates. The approach primarily involves molecular phylogenetic analysis of phototransduction protein sequences, combined with analysis of the syntenic arrangement of the genes. At least 35 of these phototransduction gene…
  • Contact lens-related corneal infection: Intrinsic resistance and its compromise. [Review]
    Prog Retin Eye Res. 2019 Nov 20 [Online ahead of print]Fleiszig SMJ, Kroken AR, … Evans DJ
  • Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ~2 to ~20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that the pathogenesis of …
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