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(Progress in retinal and eye research[TA])
705 results
  • Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. [Review]
    Prog Retin Eye Res 2020; :100829Agrawal R, Ding J, … CVI.grid
  • The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced incons…
  • Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications. [Review]
    Prog Retin Eye Res 2020; :100828Cuenca N, Ortuño-Lizarán I, … Pinilla I
  • Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks to its resolution and its ability to inform of the retinal state in seconds, which gives relevant information about retinal degeneration. In this review, we present an immunohistochemical description of the human and mice …
  • Age-related macular degeneration: A two-level model hypothesis. [Review]
    Prog Retin Eye Res 2019; :100825Rozing MP, Durhuus JA, … Sørensen TL
  • Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pa…
  • Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis. [Review]
    Prog Retin Eye Res 2019; :100826Jonas RA, Ung L, … Chodosh J
  • Known to occur in widespread outbreaks, epidemic keratoconjunctivitis (EKC) is a severe ocular surface infection with a strong historical association with human adenovirus (HAdV). While the conjunctival manifestations can vary from mild follicular conjunctivitis to hyper-acute, exudative conjunctivitis with formation of conjunctival membranes, EKC is distinct as the only form of adenovirus conjun…
  • Recapitulating developmental mechanisms for retinal regeneration. [Review]
    Prog Retin Eye Res 2019; :100824Ahmad I, Teotia P, … Xia X
  • Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat b…
  • Evolution of the genes mediating phototransduction in rod and cone photoreceptors. [Review]
    Prog Retin Eye Res 2019; :100823Lamb TD
  • This paper reviews current knowledge of the evolution of the multiple genes encoding proteins that mediate the process of phototransduction in rod and cone photoreceptors of vertebrates. The approach primarily involves molecular phylogenetic analysis of phototransduction protein sequences, combined with analysis of the syntenic arrangement of the genes. At least 35 of these phototransduction gene…
  • Contact lens-related corneal infection: Intrinsic resistance and its compromise. [Journal Article]
    Prog Retin Eye Res 2019; :100804Fleiszig SMJ, Kroken AR, … Evans DJ
  • Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ~2 to ~20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that the pathogenesis of …
  • Spatiotemporal changes in the human lens proteome: Critical insights into long-lived proteins. [Review]
    Prog Retin Eye Res 2019; :100802Schey KL, Wang Z, … Truscott RJW
  • The ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging from newly differentiated cells containing newly synthesized proteins to cells and proteins that are as old as the organism. Thus, the ocular lens is an excellent model for studying long-lived proteins (LLPs) and the effects of aging and post-translational modifications on protein structure and function…
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