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(Progress in retinal and eye research[TA])
715 results
  • Extracellular vesicle therapy for retinal diseases. [Review]
    Prog Retin Eye Res. 2020 Mar 10 [Online ahead of print]Mead B, Tomarev S
  • Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more rece…
  • Iatrogenic Ophthalmic Artery Occlusion and Retinal Artery Occlusion. [Review]
    Prog Retin Eye Res. 2020 Mar 09 [Online ahead of print]Lee JS, Kim JY, … Woo SJ
  • Iatrogenic ophthalmic artery occlusion (IOAO) is a rare but devastating ophthalmic disease that may cause sudden and permanent visual loss. Understanding the possible etiologic modalities and pathogenic mechanisms of IOAO may prevent its occurrence. There are numerous medical etiologies of IOAO, including cosmetic facial filler injection, intravascular procedures, intravitreal gas or drug injecti…
    Prog Retin Eye Res. 2020 Mar 06 [Online ahead of print]Sebag J
  • Macromolecules comprise only 2% of vitreous, yet account for its gel state, transparency, and physiologic function(s) within the eye. Myopia and aging alter collagen and hyaluronan association causing concurrent gel liquefaction and fibrous degeneration. The resulting vitreous opacities and collapse of the vitreous body during posterior vitreous detachment are the most common causes for the visua…
  • The cell biology of the retinal pigment epithelium. [Review]
    Prog Retin Eye Res. 2020 Feb 24 [Online ahead of print]Lakkaraju A, Umapathy A, … Williams DS
  • The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology o…
  • No flow through the vitreous humor: How strong is the evidence? [Review]
    Prog Retin Eye Res. 2020 Feb 06 [Online ahead of print]Smith DW, Lee CJ, Gardiner BS
  • When analyzing vitreal drug delivery, or the pharmacological effects of drugs on intraocular pressure, or when interpreting outflow facility measurements, it is generally accepted that the fluid in the vitreous humor is stagnant. It is accepted that for all practical purposes, the aqueous fluid exits the eye via anterior pathways only, and so there is negligible if any posteriorly directed flow o…
  • Cell types and cell circuits in human and non-human primate retina. [Review]
    Prog Retin Eye Res. 2020 Feb 05 [Online ahead of print]Grünert U, Martin PR
  • This review summarizes our current knowledge of primate including human retina focusing on bipolar, amacrine and ganglion cells and their connectivity. We have two main motivations in writing. Firstly, recent progress in non-invasive imaging methods to study retinal diseases mean that better understanding of the primate retina is becoming an important goal both for basic and for clinical sciences…
  • Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies. [Review]
    Prog Retin Eye Res. 2020 Jan 29 [Online ahead of print]Nielsen NS, Poulsen ET, … Enghild JJ
  • Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human TGFBIp. To date, 74 mutations in the transforming growth factor-β-induced gene (TGFBI) are associated with amylo…
  • Advances in the diagnosis and treatment of dry eye. [Review]
    Prog Retin Eye Res. 2020 Jan 29 [Online ahead of print]Kojima T, Dogru M, … Tsubota K
  • The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, an…
  • Ocular blood flow as a clinical observation: value, limitations and data analysis. [Journal Article]
    Prog Retin Eye Res. 2020 Jan 24 [Online ahead of print]Harris A, Guidoboni G, … Arciero J
  • Alterations in ocular blood flow have been identified as important risk factors for the onset and progression of numerous diseases of the eye. In particular, several population-based and longitudinal-based studies have provided compelling evidence of hemodynamic biomarkers as independent risk factors for ocular disease throughout several different geographic regions. Despite this evidence, the re…
  • A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head. [Review]
    Prog Retin Eye Res. 2020 Jan 23 [Online ahead of print]Lee EJ, Han JC, … Kee C
  • Neuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change. However, the precise mechanism of the rim thinning has not been completely elucidated. This review focuses on the structural role of the glioarchitecture in the formation of the glaucomatous NRR thinning. The NRR is a glia-framed structure, with honeycomb geometry and mechanically reinforced astrocyte processes al…
  • Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. [Review]
    Prog Retin Eye Res. 2020 Jan 10 [Online ahead of print]Agrawal R, Ding J, … CVI.grid
  • The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced incons…
  • Interpretation of OCT and OCTA images from a histological approach: Clinical and experimental implications. [Review]
    Prog Retin Eye Res. 2020 Jan 03 [Online ahead of print]Cuenca N, Ortuño-Lizarán I, … Pinilla I
  • Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a technological breakthrough in the diagnosis, treatment, and follow-up of many retinal diseases, thanks to its resolution and its ability to inform of the retinal state in seconds, which gives relevant information about retinal degeneration. In this review, we present an immunohistochemical description of the human and mice …
  • Age-related macular degeneration: A two-level model hypothesis. [Review]
    Prog Retin Eye Res. 2019 Dec 30 [Online ahead of print]Rozing MP, Durhuus JA, … Sørensen TL
  • Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent priority to understand the connections between underlying ageing mechanisms and pa…
  • Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis. [Review]
    Prog Retin Eye Res. 2019 Dec 28 [Online ahead of print]Jonas RA, Ung L, … Chodosh J
  • Known to occur in widespread outbreaks, epidemic keratoconjunctivitis (EKC) is a severe ocular surface infection with a strong historical association with human adenovirus (HAdV). While the conjunctival manifestations can vary from mild follicular conjunctivitis to hyper-acute, exudative conjunctivitis with formation of conjunctival membranes, EKC is distinct as the only form of adenovirus conjun…
  • Recapitulating developmental mechanisms for retinal regeneration. [Review]
    Prog Retin Eye Res. 2019 Dec 14 [Online ahead of print]Ahmad I, Teotia P, … Xia X
  • Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat b…
  • Evolution of the genes mediating phototransduction in rod and cone photoreceptors. [Review]
    Prog Retin Eye Res. 2019 Nov 29 [Online ahead of print]Lamb TD
  • This paper reviews current knowledge of the evolution of the multiple genes encoding proteins that mediate the process of phototransduction in rod and cone photoreceptors of vertebrates. The approach primarily involves molecular phylogenetic analysis of phototransduction protein sequences, combined with analysis of the syntenic arrangement of the genes. At least 35 of these phototransduction gene…
  • Contact lens-related corneal infection: Intrinsic resistance and its compromise. [Journal Article]
    Prog Retin Eye Res. 2019 Nov 20 [Online ahead of print]Fleiszig SMJ, Kroken AR, … Evans DJ
  • Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an approximate annualized incidence ranging from ~2 to ~20 cases per 10,000 wearers, and sometimes resulting in permanent vision loss. Research suggests that the pathogenesis of …
  • Spatiotemporal changes in the human lens proteome: Critical insights into long-lived proteins. [Review]
    Prog Retin Eye Res. 2019 Nov 06 [Online ahead of print]Schey KL, Wang Z, … Truscott RJW
  • The ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging from newly differentiated cells containing newly synthesized proteins to cells and proteins that are as old as the organism. Thus, the ocular lens is an excellent model for studying long-lived proteins (LLPs) and the effects of aging and post-translational modifications on protein structure and function…
  • Beyond intraocular pressure: Optimizing patient-reported outcomes in glaucoma. [Review]
    Prog Retin Eye Res. 2019 Oct 31 [Online ahead of print]Fenwick EK, Man RE, … Lamoureux EL
  • Glaucoma, an irreversible blinding condition affecting 3-4% adults aged above 40 years worldwide, is set to increase with a rapidly aging global population. Raised intraocular pressure (IOP) is a major risk factor for glaucoma where the treatment paradigm is focused on managing IOP using medications, laser, or surgery regimens. However, notwithstanding IOP and other clinical parameters, patient-r…
  • Uveal melanoma: Towards a molecular understanding. [Review]
    Prog Retin Eye Res. 2019 Sep 26 [Online ahead of print]Smit KN, Jager MJ, … Kiliҫ E
  • Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye. Even if the primary tumor has been successfully treated with radiation or surgery, up to half of all UM patients will eventually develop metastatic disease. Despite the common origin from neural crest-derived cells, uveal and cutaneous melanoma have few overlapping genetic signatures and uveal melanoma has bee…
  • Melatonin and the control of intraocular pressure. [Review]
    Prog Retin Eye Res. 2019 Sep 25 [Online ahead of print]Alkozi HA, Navarro G, … Pintor J
  • Melatonin is not only synthesized by the pineal gland but by several ocular structures. This natural indoleamine is of great importance for regulating several eye processes, among which pressure homeostasis is included. Glaucoma, the most prevalent eye disease, also known as the silent thief of vision, is a multifactorial pathology that is associated to age and, often, to intraocular hypertension…
  • Inducible rodent models of glaucoma. [Journal Article]
    Prog Retin Eye Res. 2019 Sep 23 [Online ahead of print]Pang IH, Clark AF
  • Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and…
  • Optical coherence tomography diagnostic signs in posterior uveitis. [Review]
    Prog Retin Eye Res. 2019 Sep 09 [Online ahead of print]Pichi F, Invernizzi A, … Munk MR
  • A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a sign used to accelerate or aid in diagnosis or monitoring and provide insight into "personalized" medicine. Many…
  • Innate immune response in retinal homeostasis and inflammatory disorders. [Review]
    Prog Retin Eye Res. 2019 Sep 07 [Online ahead of print]Murakami Y, Ishikawa K, … Sonoda KH
  • Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis, these cells and immunosuppressive molecules in the eye actively regulate the induction and the expression of inflammation in order to prevent excessive activation and subsequent tissue damage. In the disease context, t…
  • Diurnal rodents as pertinent animal models of human retinal physiology and pathology. [Review]
    Prog Retin Eye Res. 2019 Sep 06 [Online ahead of print]Verra DM, Sajdak BS, … Hicks D
  • This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal complement to rats and mice. These diurnal rodents also possess unusually cone-rich photoreceptor mosaics that facilitate the study of cone cells and pathways. Species to be presented include principally the Sudanian Unstriped Grass Rat and Nile …
  • Retinal stem cell transplantation: Balancing safety and potential. [Review]
    Prog Retin Eye Res. 2019 Sep 05 [Online ahead of print]Singh MS, Park SS, … Bharti K
  • Stem cell transplantation holds great promise as a potential treatment for currently incurable retinal degenerative diseases that cause poor vision and blindness. Recently, safety data have emerged from several Phase I/II clinical trials of retinal stem cell transplantation. These clinical trials, usually run in partnership with academic institutions, are based on sound preclinical studies and ar…
  • Stromal keratophakia: Corneal inlay implantation. [Review]
    Prog Retin Eye Res. 2019 Sep 04 [Online ahead of print]Riau AK, Liu YC, … Mehta JS
  • Stromal keratophakia was first performed by José Ignacio Barraquer in the 1960s. The refractive lamellar keratoplasty technique was intensely pursued in the 1980s as a method to alter corneal refractive power. However, because sculpting of the donor stromal lenticule and lamellar keratectomy of the recipient's cornea were performed with a mechanical microkeratome, the quality of the cut was incon…
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