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(Progress in retinal and eye research[TA])
782 results
  • Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies. [Review]
    Prog Retin Eye Res. 2021 Apr 28 [Online ahead of print]Eastlake K, Lamb WDB, … Limb GA
  • Neural cell death is the main feature of all retinal degenerative disorders that lead to blindness. Despite therapeutic advances, progression of retinal disease cannot always be prevented, and once neuronal cell damage occurs, visual loss cannot be reversed. Recent research in the stem cell field, and the identification of Müller glia with stem cell characteristics in the human eye, have provided…
  • Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology. [Review]
    Prog Retin Eye Res. 2021 Apr 13 [Online ahead of print]Strub T, Martel A, … Bertolotto C
  • Uveal melanoma (UM) is an aggressive and deadly neoplasm. In recent decades, great efforts have been made to obtain a more comprehensive understanding of genetics, genomics and molecular changes in UM, enabling the identification of key cellular processes and signalling pathways. Still, there is no effective treatment for the metastatic disease. Intratumoural heterogeneity (ITH) is thought to be …
  • Mesenchymal stromal cells for the treatment of ocular autoimmune diseases. [Journal Article]
    Prog Retin Eye Res. 2021 Mar 26 [Online ahead of print]Oh JY, Lee RH
  • Mesenchymal stromal cells, commonly referred to as MSCs, have emerged as a promising cell-based therapy for a range of autoimmune diseases thanks to several therapeutic advantages. Key among these are: 1) the ability to modulate innate and adaptive immune responses and to promote tissue regeneration, 2) the ease of their isolation from readily accessible tissues and expansion at scale in culture,…
  • Artificial intelligence in OCT angiography. [Review]
    Prog Retin Eye Res. 2021 Mar 22 [Online ahead of print]Hormel TT, Hwang TS, … Jia Y
  • Optical coherence tomographic angiography (OCTA) is a non-invasive imaging modality that provides three-dimensional, information-rich vascular images. With numerous studies demonstrating unique capabilities in biomarker quantification, diagnosis, and monitoring, OCTA technology has seen rapid adoption in research and clinical settings. The value of OCTA imaging is significantly enhanced by image …
  • Photocoagulation for retinal vein occlusion. [Review]
    Prog Retin Eye Res. 2021 Mar 11 [Online ahead of print]Hayreh SS
  • The role of photocoagulation in retinal vein occlusion (RVO) has been studied since 1974. The most serious complications of central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) are: (i) visual deterioration, most commonly due to macular edema, and (ii) the development of ocular neovascularization (NV), particularly neovascular glaucoma (NVG), with hazardous consequences …
  • Human limbal epithelial stem cell regulation, bioengineering and function. [Review]
    Prog Retin Eye Res. 2021 Mar 04 [Online ahead of print]Bonnet C, González S, … Deng SX
  • The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opac…
  • VEGFR1 signaling in retinal angiogenesis and microinflammation. [Review]
    Prog Retin Eye Res. 2021 Feb 25 [Online ahead of print]Uemura A, Fruttiger M, … Langmann T
  • Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, -C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas VEGF-B and PlGF only bind VEGFR1. Although much research has been conducted on VEGFR2 to elucidate its key role in retinal diseases, recent efforts have shown the importance and involvement of …
  • Adaptive responses to neurodegenerative stress in glaucoma. [Review]
    Prog Retin Eye Res. 2021 Feb 25 [Online ahead of print]Calkins DJ
  • Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC) projection to the brain. The disease is characterized by sensitivity to intraocular pressure (IOP) conveyed at the optic nerve head, through which RGC axons pass unmyelinated to form the optic nerve. From this point, a pathogenic triumvirate comprising inflammatory, oxidative, and metabolic stress influence bot…
  • Implications of genetic variation in the complement system in age-related macular degeneration. [Review]
    Prog Retin Eye Res. 2021 Feb 19 [Online ahead of print]de Jong S, Gagliardi G, … den Hollander AI
  • Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was identified as one of the main pathways contributing to disease risk. The strong link between the complement system and AMD was demonstrated by genetic associations, and by elevated complement activation in local eye tissue…
  • Immunological aspects of RPE cell transplantation. [Review]
    Prog Retin Eye Res. 2021 Jan 19 [Online ahead of print]Sugita S, Mandai M, … Takahashi M
  • Retinal pigment epithelial (RPE) cells have several functions, including support of the neural retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly suppress inflammatory immune cells. For instance, they directly suppress the activation of T cells in vitro. In contrast, transplanted allogeneic human RPE cells are rejected by bystander immune cells such as T cells …
  • Past, present and future role of retinal imaging in neurodegenerative disease. [Review]
    Prog Retin Eye Res. 2021 Jan 15 [Online ahead of print]Kashani AH, Asanad S, … Ringman JM
  • Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as opti…
  • The innate immune system in diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2021 Jan 08 [Online ahead of print]Pan WW, Lin F, Fort PE
  • The prevalence of diabetes has been rising steadily in the past half-century, along with the burden of its associated complications, including diabetic retinopathy (DR). DR is currently the most common cause of vision loss in working-age adults in the United States. Historically, DR has been diagnosed and classified clinically based on what is visible by fundoscopy; that is vasculature alteration…
  • Uncoupling proteins in the mitochondrial defense against oxidative stress. [Review]
    Prog Retin Eye Res. 2021 Jan 08 [Online ahead of print]Hass DT, Barnstable CJ
  • Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-oxidative strategies have been insufficient at counteracting one of the predominant intrinsic sources of reactive oxygen species (ROS), mitochondria. The proton gradient across the inner mitochondrial membrane is a key driving force for mitochondrial ROS production, and this gradient can be modulated by memb…
  • Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. [Review]
    Prog Retin Eye Res. 2020 Dec 28 [Online ahead of print]Voigt AP, Mullin NK, … Mullins RF
  • Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand retinal physiology and disease. With the advent of single-cell RNA sequencing, expression experiments provide an unparalleled resolution of information. Instead of studying aggregated gene expression across all cells in a heterogenous tiss…
  • Dominant optic atrophy: Culprit mitochondria in the optic nerve. [Review]
    Prog Retin Eye Res. 2020 Dec 17 [Online ahead of print]Lenaers G, Neutzner A, … Wissinger B
  • Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual information from the retina to the brain. Usually, DOA starts during childhood and evolves to poor vision or legal blindness, affecting the central vision, whilst sparing the peripheral visual field. In 20% of cases, DOA pre…
  • Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. [Review]
    Prog Retin Eye Res. 2020 Dec 13 [Online ahead of print]Kim BJ, Mastellos DC, … Lambris JD
  • Age-related macular degeneration (AMD) remains a major cause of legal blindness, and treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation of the complement cascade is thought to be instrumental for AMD pathophysiology. In particular, C3 and C5 are pivotal components of the complement cascade and have become leading therapeutic targets for AMD. In this articl…
  • Efficacy in myopia control. [Review]
    Prog Retin Eye Res. 2020 Nov 27 [Online ahead of print]Brennan NA, Toubouti YM, … Bullimore MA
  • There is rapidly expanding interest in interventions to slow myopia progression in children and teenagers, with the intent of reducing risk of myopia-associated complications later in life. Despite many publications dedicated to the topic, little attention has been devoted to understanding 'efficacy' in myopia control and its application. Treatment effect has been expressed in multiple ways, maki…
  • The vital role for nitric oxide in intraocular pressure homeostasis. [Review]
    Prog Retin Eye Res. 2020 Nov 28 [Online ahead of print]Reina-Torres E, De Ieso ML, … Stamer WD
  • Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO regulates the contractility of vascular smooth muscle cells and permeability of endothelial cells in response to either biochemical or biomechanical cues. In the conventional outflow pathway of the eye, the smooth muscle-li…
  • Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases. [Review]
    Prog Retin Eye Res. 2020 Nov 25 [Online ahead of print]Campochiaro PA, Akhlaq A
  • Neovascular age-related macular degeneration (NVAMD) is the most prevalent choroidal vascular disease, and diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the most prevalent retinal vascular diseases. In each of these, hypoxia plays a central role by stabilizing hypoxia-inducible factor-1 which increases production of vascular endothelial growth factor (VEGF) and other hypoxia-regu…
  • Aqueous outflow regulation - 21st century concepts. [Review]
    Prog Retin Eye Res. 2020 Nov 17 [Online ahead of print]Johnstone M, Xin C, … Wang RK
  • We propose an integrated model of aqueous outflow control that employs a pump-conduit system in this article. Our model exploits accepted physiologic regulatory mechanisms such as those of the arterial, venous, and lymphatic systems. Here, we also provide a framework for developing novel diagnostic and therapeutic strategies to improve glaucoma patient care. In the model, the trabecular meshwork …
  • Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2020 Nov 12 [Online ahead of print]Tonade D, Kern TS
  • Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Rec…
  • Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease. [Review]
    Prog Retin Eye Res. 2020 Oct 29 [Online ahead of print]Mullin NK, Voigt AP, … Tucker BA
  • Our understanding of inherited retinal disease has benefited immensely from molecular genetic analysis over the past several decades. New technologies that allow for increasingly detailed examination of a patient's DNA have expanded the catalog of genes and specific variants that cause retinal disease. In turn, the identification of pathogenic variants has allowed the development of gene therapie…
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