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(Progress in retinal and eye research[TA])
771 results
  • Implications of genetic variation in the complement system in age-related macular degeneration. [Review]
    Prog Retin Eye Res. 2021 Feb 18 [Online ahead of print]de Jong S, Gagliardi G, … den Hollander AI
  • Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was identified as one of the main pathways contributing to disease risk. The strong link between the complement system and AMD was demonstrated by genetic associations, and by elevated complement activation in local eye tissue…
  • Immunological aspects of RPE cell transplantation. [Review]
    Prog Retin Eye Res. 2021 Jan 19 [Online ahead of print]Sugita S, Mandai M, … Takahashi M
  • Retinal pigment epithelial (RPE) cells have several functions, including support of the neural retina and choroid in the eye and immunosuppression. Cultured human RPE cells directly suppress inflammatory immune cells. For instance, they directly suppress the activation of T cells in vitro. In contrast, transplanted allogeneic human RPE cells are rejected by bystander immune cells such as T cells …
  • Past, present and future role of retinal imaging in neurodegenerative disease. [Review]
    Prog Retin Eye Res. 2021 Jan 15 [Online ahead of print]Kashani AH, Asanad S, … Ringman JM
  • Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as opti…
  • The innate immune system in diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2021 Jan 08 [Online ahead of print]Pan WW, Lin F, Fort PE
  • The prevalence of diabetes has been rising steadily in the past half-century, along with the burden of its associated complications, including diabetic retinopathy (DR). DR is currently the most common cause of vision loss in working-age adults in the United States. Historically, DR has been diagnosed and classified clinically based on what is visible by fundoscopy; that is vasculature alteration…
  • Uncoupling proteins in the mitochondrial defense against oxidative stress. [Review]
    Prog Retin Eye Res. 2021 Jan 08 [Online ahead of print]Hass DT, Barnstable CJ
  • Oxidative stress is a major component of most major retinal diseases. Many extrinsic anti-oxidative strategies have been insufficient at counteracting one of the predominant intrinsic sources of reactive oxygen species (ROS), mitochondria. The proton gradient across the inner mitochondrial membrane is a key driving force for mitochondrial ROS production, and this gradient can be modulated by memb…
  • Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. [Review]
    Prog Retin Eye Res. 2020 Dec 28 [Online ahead of print]Voigt AP, Mullin NK, … Mullins RF
  • Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand retinal physiology and disease. With the advent of single-cell RNA sequencing, expression experiments provide an unparalleled resolution of information. Instead of studying aggregated gene expression across all cells in a heterogenous tiss…
  • Dominant optic atrophy: Culprit mitochondria in the optic nerve. [Review]
    Prog Retin Eye Res. 2020 Dec 17 [Online ahead of print]Lenaers G, Neutzner A, … Wissinger B
  • Dominant optic atrophy (DOA) is an inherited mitochondrial disease leading to specific degeneration of retinal ganglion cells (RGCs), thus compromising transmission of visual information from the retina to the brain. Usually, DOA starts during childhood and evolves to poor vision or legal blindness, affecting the central vision, whilst sparing the peripheral visual field. In 20% of cases, DOA pre…
  • Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. [Review]
    Prog Retin Eye Res. 2020 Dec 13 [Online ahead of print]Kim BJ, Mastellos DC, … Lambris JD
  • Age-related macular degeneration (AMD) remains a major cause of legal blindness, and treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation of the complement cascade is thought to be instrumental for AMD pathophysiology. In particular, C3 and C5 are pivotal components of the complement cascade and have become leading therapeutic targets for AMD. In this articl…
  • Efficacy in myopia control. [Review]
    Prog Retin Eye Res. 2020 Nov 27 [Online ahead of print]Brennan NA, Toubouti YM, … Bullimore MA
  • There is rapidly expanding interest in interventions to slow myopia progression in children and teenagers, with the intent of reducing risk of myopia-associated complications later in life. Despite many publications dedicated to the topic, little attention has been devoted to understanding 'efficacy' in myopia control and its application. Treatment effect has been expressed in multiple ways, maki…
  • The vital role for nitric oxide in intraocular pressure homeostasis. [Review]
    Prog Retin Eye Res. 2020 Nov 28 [Online ahead of print]Reina-Torres E, De Ieso ML, … Stamer WD
  • Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO regulates the contractility of vascular smooth muscle cells and permeability of endothelial cells in response to either biochemical or biomechanical cues. In the conventional outflow pathway of the eye, the smooth muscle-li…
  • Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases. [Review]
    Prog Retin Eye Res. 2020 Nov 25 [Online ahead of print]Campochiaro PA, Akhlaq A
  • Neovascular age-related macular degeneration (NVAMD) is the most prevalent choroidal vascular disease, and diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the most prevalent retinal vascular diseases. In each of these, hypoxia plays a central role by stabilizing hypoxia-inducible factor-1 which increases production of vascular endothelial growth factor (VEGF) and other hypoxia-regu…
  • Aqueous outflow regulation - 21st century concepts. [Review]
    Prog Retin Eye Res. 2020 Nov 17 [Online ahead of print]Johnstone M, Xin C, … Wang RK
  • We propose an integrated model of aqueous outflow control that employs a pump-conduit system in this article. Our model exploits accepted physiologic regulatory mechanisms such as those of the arterial, venous, and lymphatic systems. Here, we also provide a framework for developing novel diagnostic and therapeutic strategies to improve glaucoma patient care. In the model, the trabecular meshwork …
  • Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2020 Nov 12 [Online ahead of print]Tonade D, Kern TS
  • Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Rec…
  • Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease. [Review]
    Prog Retin Eye Res. 2020 Oct 29 [Online ahead of print]Mullin NK, Voigt AP, … Tucker BA
  • Our understanding of inherited retinal disease has benefited immensely from molecular genetic analysis over the past several decades. New technologies that allow for increasingly detailed examination of a patient's DNA have expanded the catalog of genes and specific variants that cause retinal disease. In turn, the identification of pathogenic variants has allowed the development of gene therapie…
  • Inflammation in Glaucoma: From the back to the front of the eye, and beyond. [Review]
    Prog Retin Eye Res. 2020 Oct 17 [Online ahead of print]Baudouin C, Kolko M, … Messmer EM
  • The pathophysiology of glaucoma is complex, multifactorial and not completely understood. Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic nerve damage. In addition, age-related oxidative stress in the retina concurrently with chronic mechanical and vascular stress is crucial for the initiation of retinal neurodegeneration. Oxidative stress is closely…
  • Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials. [Review]
    Prog Retin Eye Res. 2020 Oct 03 [Online ahead of print]Pfau M, Jolly JK, … Schmitz-Valckenberg S
  • Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP can provide insightful information about disease severity and progression not reflected by best-corrected visual acui…
  • Zinn's zonule. [Review]
    Prog Retin Eye Res. 2020 Sep 25 [Online ahead of print]Bassnett S
  • The Zonule of Zinn, or ciliary zonule, is the elaborate system of extracellular fibers that centers the lens in the eye. In humans, the fibers transmit forces that flatten the lens during the process of disaccommodation, thereby bringing distant objects into focus. Zonular fibers are composed almost entirely of 10-12 nm-wide microfibrils, of which polymerized fibrillin is the most abundant compon…
  • Corneal endothelial dysfunction: Evolving understanding and treatment options. [Review]
    Prog Retin Eye Res. 2020 Sep 22 [Online ahead of print]Price MO, Mehta JS, … Price FW
  • The cornea is exquisitely designed to protect the eye while transmitting and focusing incoming light. Precise control of corneal hydration by the endothelial cell layer that lines the inner surface of the cornea is required for optimal transparency, and endothelial dysfunction or damage can result in corneal edema and visual impairment. Advances in corneal transplantation now allow selective repl…
  • Posterior capsule opacification: What's in the bag? [Review]
    Prog Retin Eye Res. 2020 Sep 22 [Online ahead of print]Wormstone IM, Wormstone YM, … Eldred JA
  • Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a marked impact on the wellbeing and productivity of individuals and has a major economic impact on healthcare providers. The only means of treating cataract is by surgical intervention. A modern cataract operation generates a capsular bag, which comprises a proportion of the anterior capsule and the enti…
  • Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy. [Review]
    Prog Retin Eye Res. 2020 Sep 17 [Online ahead of print]Roy S, Kim D
  • Vascular basement membrane (BM) thickening has been hailed over half a century as the most prominent histological lesion in diabetic microangiopathy, and represents an early ultrastructural change in diabetic retinopathy (DR). Although vascular complications of DR have been clinically well established, specific cellular and molecular mechanisms underlying dysfunction of small vessels are not well…
  • Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective. [Review]
    Prog Retin Eye Res. 2020 Sep 06 [Online ahead of print]Li JO, Liu H, … Ting DSW
  • The simultaneous maturation of multiple digital and telecommunications technologies in 2020 has created an unprecedented opportunity for ophthalmology to adapt to new models of care using tele-health supported by digital innovations. These digital innovations include artificial intelligence (AI), 5th generation (5G) telecommunication networks and the Internet of Things (IoT), creating an inter-de…
  • Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma. [Review]
    Prog Retin Eye Res. 2020 Sep 04 [Online ahead of print]Kompella UB, Hartman RR, Patil MA
  • Although once daily anti-glaucoma drug therapy is a current clinical reality, most therapies require multiple dosing and there is an unmet need to develop convenient, safe, and effective sustained release drug delivery systems for long-term treatment to improve patient adherence and outcomes. One of the first sustained release drug delivery systems was approved for the reduction of intraocular pr…
  • Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances. [Review]
    Prog Retin Eye Res. 2020 Sep 02 [Online ahead of print]Gupta VB, Chitranshi N, … Gupta V
  • Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically characterised by cognitive deficits that gradually worsen over time. There is, at present, no established cure, or disease-modifying treatments for AD. As life expectancy increases globally, the number of individuals suffering from the disease is projected to increase substantially. Cumulative evidence i…
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