Serum micronutrient analysis can provide insight into diet and clinical assessment, despite the complicated interplay between micronutrients and species idiosyncrasies. Approach serum nutrient analytes with skepticism, before jumping to alter diets or offering supplementation. Utilize across species but know that some exotics have exceptions to typical ranges, such as calcium in rabbits or iron in reptiles. Make sure you trust that referenced ranges reflect normal and healthy for that species. Micronutrients are integral to every bodily process, so measurement of serum analytes can tell a story that aids in the clinical picture, when one can recognize what stands out.

Lameness in bulls is a common problem seen by many veterinarians, and the cause can be difficult to determine. Understanding cattle lameness requires experience and complete knowledge of their structural anatomy and handling. This article reviews the common body regions that cause lameness in bulls and discusses their treatment. It also details hoof trimming as a way to manage lameness.

Like many physical disorders, the clinical signs associated with metabolic diseases affecting thyroid, adrenal, and pancreatic function are reflective of nonspecific changes in behavior. Additionally, patients who have underlying disorders associated with fear, anxiety, stress, conflict, and/or panic may be under treatment with medications that alter basal thyroid, glucose, and cortisol levels. Through reinforcement and punishment of behaviors associated with clinical signs caused by organic or iatrogenic endocrine disease, behaviors can be perpetuated and become persistent patterns. Screening all patients presenting with a primary behavior complaint or those with behavioral clinical signs of endocrine diseases is essential. Alleviating stress immediately while working up or treating metabolic disease reduces suffering and may stave off the adoption of behavior patterns more permanently.

Working dogs perform complex tasks that require both physical and behavioral soundness. Two case studies demonstrate how fitness training moderated arousal levels, facilitated training, and improved performance measures in different situations. Fitness training can be beneficial when integrated as part of a working dog's training regimen because it can have a significant influence on their overall health, behavior, and ability to perform their working role effectively.

Behavior changes may indicate primary physical disease or primary behavioral disorders in veterinary patients. It is imperative to recognize that secondary behavioral problems can develop due to medical causes. The incidence of systemic disease increases with age and behavior manifestations can be similar to those expected with cognitive dysfunction syndrome. In this article, we review basic concepts of cognition, aging, and cognitive dysfunction syndrome. Additionally, we provide information regarding factors that influence cognition, and the role medical conditions have on the behavior of aging pets.

Sickness is a normal response to infections or stress triggered by proinflammatory cytokines that drive local and systemic inflammatory responses. Proinflammatory cytokines act on the brain causing the so called "sickness behavior,"which is thought to improve recovery but can become maladaptive in the long term. Chronic inflammation characterizes many diseases and there is some evidence that dogs and cats experience age-associated increases in inflammation, a condition named "inflammaging." A complex and multifactorial relationship exists between these inflammatory mechanisms, pain, and psychological illness that may complicate veterinary diagnosis and affect the outcome.

Behavioral and physical health are intricately interconnected in most animals, and the rabbit is no different. Medical or physical conditions can lead to anxiety and stress, and anxiety and stress can lead to physical illness. Rabbits are very prone to fear, anxiety, and stress, especially when their husbandry is not appropriate and their environmental and behavioral needs are not met. Any rabbit presenting for acute behavior changes should be examined thoroughly for underlying medical conditions and the appropriateness of their environment examined equally closely. Physical health is unlikely to exist without behavioral and/or emotional health and vice versa.

The condition of separation-related problems (SRPs) is common in companion dogs and clinicians should be comfortable diagnosing it. There are numerous diagnoses related to physical disease that have clinical signs similar to SRP, that exacerbate SRP, or may cause regression in treatment of SRP. Common examples include conditions affecting the following systems: musculoskeletal, neurologic, gastrointestinal, and dermatologic. Therefore, it is important for clinicians to rule out causes of physical disease and address them accordingly. The signalment of the patient, medications they are receiving, and other behavioral comorbidities should also be considered.

Cantharidin is the toxic component of blister beetles of the genus Epicauta. Cantharidin is a potent vesicant which causes blisters, erosions, and ulcerations in the gastrointestinal and urinary tracts, and can cause myocardial necrosis. Blister beetles are found over most of North America and specifically contaminate alfalfa at harvest. History of alfalfa feeding, with colic, dysuria, hypocalcemia, and hypomagnesemia are suggestive of blister beetle toxicosis. Myocardial damage causes increased serum cardiac troponin 1. Tentative diagnosis can be made by finding the beetles in feed or ingesta. Definitive diagnosis requires detection of cantharidin in urine or gastric contents. Treatment involves ending exposure, decreasing absorption, controlling pain, using gastroprotectants, and fluids and electrolyte replacement. Prognosis is guarded to poor.

Snakebite envenomation (SBE) in horses can have devastating outcomes. Tissue damage, cardiotoxicity, coagulopathy, and neurotoxicity can be concerns with SBE. Understanding the actions of venom components is important in developing a successful treatment plan. Antivenom is the mainstay of treatment. Long-term deleterious effects can occur including cardiac dysfunction and lameness.

Aggression is a very common behavioral problem in dogs. Although aggression can be part of the normal behavior of dogs, medical conditions can either trigger aggression as in the case of intracranial tumors or aggravate an existing aggression problem as it happens with painful conditions. Therefore, it is essential to include an assessment of physical health in the diagnostic protocol of canine aggression.

Evidence-based recommendations for the amount, type, and frequency of food items and supplements are lacking for bearded dragons. General recommendations based on ecological data, a few studies, and experts in the field are to: provide at least 50% high-fiber plant matter dusted in pure calcium and less than 50% adult and lower fat larval insects gut loaded with an 8% calcium diet and dusted with pure calcium, provide ultraviolet B lighting for vitamin D3 synthesis, provide multivitamins on a weekly basis, or monthly at minimum, provide a water dish large enough to soak and drink.

Malnutrition is a known concern during hospitalization for humans, dogs, and cats. The same nutrition principals to reduce the risk of malnutrition can be applied to exotic companion animal patients. However, it's important to understand that many nutritional requirements are ill defined for specific species and prudent clinical judgment is required.

The use of in vitro embryo production (IVP) has increased globally, particularly in the United States. Although maternal factors influencing embryo development have been extensively studied, the influence of the sire is not well understood. Sperm plays a crucial role in embryo development providing DNA, triggering oocyte maturation, and aiding in mitosis. Current sire fertility measurements do not consistently align with embryo production outcomes. Low-fertility sires may perform well in IVP systems but produce fewer pregnancies. Testing sires in vitro could identify characteristics affecting embryo development and pregnancy loss risk in IVP and embryo transfer programs.

Ionophores are a class of polyether antibiotics that are commonly used as anticoccidial agents and growth promotants in ruminant diets. Ionophores transport ions across lipid membranes and down concentration gradients, which results in mitochondrial destruction, reduced cellular energy production, and ultimately cell death. Cardiomyocytes are the primary target in equine patients when exposed to toxic concentrations and the clinical disease syndrome is related to myocardial damage. Animals can survive acute exposures but can have permanent heart damage that may result in acute death at future time points. Animals that survive a poisoning incident may live productive breeding lives, but physical performance can be greatly impacted. Animals with myocardial damage are at risk of sudden death and pose a risk to riders.

Range mineral supplementation is based on providing trace minerals not adequately provided from grazed forage in meeting beef cattle needs throughout life cycle stages. Supplementation programs should be developed with consideration of ranch production goals, economics, and practicality for implementation. Factors such as season of grazing, forage analysis, water analysis including antagonistic elements, and measured animal responses are used in mineral supplement formulation for range cattle. Mineral intake is a critical factor to a supplement program's success. Salt-based mineral products are most used under range conditions, yet there is much individual intake variation.

Reproduction is essential for successful cow-calf and dairy production and the most important economic trait for cow-calf producers. For efficient reproduction to occur in beef herds, cows or heifers must conceive early during the breeding season, maintain the pregnancy, calve unassisted or with very little assistance, rebred in a timely manner and wean a calf every year. In the case of dairy cattle, cows or heifers are expected to become pregnant, maintain the pregnancy, and calve every 12 to 15 months to produce milk. Interruption of that process leads to delay or total loss of production. Although fertile bulls are required to achieve reproduction, they come with potential risk of transmitting disease during breeding.

Estrous synchronization, coupled with natural service, provides the benefit of female cows conceiving early, but there are an increased number of females expressing estrus in a short period of time. Thus, considerations need to be made for the bull. Select a protocol that will distribute estrus over a longer period of time and ensure bulls pass a breeding soundness examination. Mature bulls (3 years old or older) have increased efficiency in getting cows pregnant compared with younger bulls; therefore, a ratio of 1 mature bull to 25 cows is a good recommendation within an estrous synchronized herd.

The article discusses the importance of reproductive biotechnologies, including artificial insemination and fixed-time artificial insemination (TAI), in beef cow-calf operations. The use of TAI improves cow-calf productivity and profitability by shortening the breeding season and increasing the number of calves born earlier, resulting in heavier calves at weaning. However, adoption of TAI by beef producers in the United States has been slow compared with the dairy industry and internationally, such as Brazil. Current TAI protocols are effective in synchronizing ovulation and yield consistent pregnancy results. Factors affecting the success of TAI include cow/heifer factors, sire, nutritional status, and cattle temperament.

This manuscript provides an overview of the effects of nutrition during different stages of bull sexual development. Nutrition during the prepubertal period can modulate the hypothalamic GnRH pulse generator. Increased nutrition results in greater LH secretion, earlier puberty, and greater testicular mass in yearling bulls, whereas low nutrition has opposite effects. Targeting average daily gain from birth to 24 weeks of age to > 1.2 kg/d and limiting gain after 24 weeks of age to < 1.6 kg/d is recommended to optimize bull sexual development.

Artificial insemination (AI) is an effective strategy to distribute semen from elite sires and improve the genetics of a herd. Commercial studs provide a fertile semen product to their customers. Consequently, the maintenance of sire fertility is dependent upon appropriate semen storage, handing, and site of semen deposition. When retrieving a straw of frozen semen, the cane (and canister containing canes) should be held below the frost-line and limited to 8 seconds in the neck of the tank. After appropriate thawing, and continuous thermoregulation of the AI gun containing the thawed semen, semen should be deposited in the uterine body.

Current evidence suggests that dairy bull fertility is influenced by genetic factors, and hence, it could be managed and improved by genetic means. There are major mutations that explain about 4% to 8% of the observed differences in conception rate between bulls segregating in most dairy breeds. Research has shown that genomic prediction of bull fertility is possible, and this could be used to make accurate genome-guided selection decisions, such as early culling of predicted subfertile bull calves. Inbreeding negatively influences bull fertility, and the increase in homozygosity seems an important risk factor for dairy bull subfertility.

Chelonian nutrition is still a young, but very important field of study. This article provides practical feeding advice for tortoises and freshwater and terrestrial turtles. Areas covered include the different feeding ecology of different types of chelonians, their digestive physiology, growth rate, body condition scoring, an overview of what types of diets items can be used in captive diets, and examples of diets used for various species of chelonians.

The stress response affects the central nervous system and multiple other systems in the body. Chronic mental and behavioral pathologies are associated with inflammation, dysfunctions in the immune response and an increased risk for other chronic inflammatory and metabolic diseases. Psychiatric treatments alleviate fear, stress and anxiety, increase the qualify of life and lifespan for dogs and cats. Multiple safe psychoactive medications that can be used in association are available to help veterinary patients. Clinicians should understand the function of neurotransmitters and hormones on emotional processing, cognition and behavior, and drug mechanism of action so medication selection is appropriate for each individual patient.

Inappropriate elimination or behavioral periuria/perichezia is likely the most reported feline behavioral problem worldwide. A change in behavior is often one of the early signs of physical disease and in addition can aggravate an existing behavioral response. An initial determination of causation is essential; is it medical or behavioral, or a combination of both? Stress activates both the sympathetic adrenomedullary system for short-term responses and the hypothalamic pituitary adrenal axis for long-term responses. Once medical problems have been treated or ruled out, attention should shift to minimizing and using various therapeutic options to help improve and/or resolve undesirable elimination problems.

Trace mineral nutrition of sheep often focuses on their greater susceptibility to copper toxicosis due to a lesser biliary excretion ability compared with other ruminants. Our understanding of sheep trace mineral requirements has improved for most elements allowing for a factorial approach to determining daily requirement instead of a dietary concentration. Forage trace mineral content is influenced by many factors making issues of trace mineral supplementation geographic-dependent. Oral delivery of trace elements is a preferred supplementation method, and this can be achieved through free choice trace mineralized salt or direct dietary incorporation.

Mini pigs are engaging, intelligent animals that require different management than other pet species. Published nutrient requirements for production pigs are a good reference, but they must be critically evaluated in the context of pet mini pigs' needs to prioritize longevity and healthy weight. A balanced diet includes a pelleted feed, vegetables, and roughage, with minimal fruit or other treats. Mini pigs easily gain weight, and a balanced, high-fiber diet helps maintain healthy body condition to reduce the risk of metabolic and joint diseases.

It is understood that ferrets are obligate carnivores. Constraints of manufacturing and cost make it difficult to align a single commercial diet to meet all physiological needs of ferrets. Thus, a combination of dietary formats should be offered. Ferret diets should be high in protein and fat and low in carbohydrates. Emphasis should be placed on fat concentrations and protein-to-fat ratios, which can be targeted at 2:1. Plant-based ingredients do not have a place in ferret diets and could unbalance diets, particularly in amino acids. Items such as fruits, while highly palatable to ferrets, should be avoided.

Insectivores are represented in virtually all taxa, although more is known about mammalian and avian insectivore nutrition than for reptiles, amphibia and fish. Establishing nutrient requirements is challenging but recommendations should be based on data from similar taxa, similar GI tract physiology, and known nutritional concerns. In order to provide an appropriate diet for insectivores, consideration must be given to anatomy and method for procuring insects in free-ranging habitats, availability of feeder insects and the resulting dietary nutrient profiles, and complementing those profiles with appropriate diet items from various other categories including formulated feed, produce, animal matter, seeds or grains etc. Consideration of known nutritional concerns for a given species, and the variation in energy requirements in a captively managed situation are essential.